Animal research that falls under restricted Human Biomedical Research (rHBR)

The Fourth Schedule of the Human Biomedical Research Act (HBRA) regulates the conduct of restricted Human Biomedical Research (rHBR) in Singapore. If your animal research involves any of the following, you are required to declare this in your IACUC application: ​

(a) the following types of human-animal combination embryos:

​(i) cytoplasmic hybrid embryos;
(ii) human-animal combination embryos created by the incorporation of human stem cells (including induced pluripotent stem cells);
(iii) human-animal combination embryos created in-vitro by using —​
      (A) human gametes and animal gametes; or​
      ​(B) one human pronucleus and one animal pronucleus​;

(b) the introduction of human stem cells (including induced pluripotent stem cells) into a prenatal animal foetus or animal embryo;

(c) the introduction of human pluripotent stem cells (including induced pluripotent stem cells) into a living postnatal animal;

(d) the introduction of human stem cells (including induced pluripotent stem cells) or human neural cells into the brain of a living postnatal animal; or

(e) any entity created as a result of any process referred to in sub paragraphs (b), (c) and (d).

In addition to NTU IACUC approval, you are required to obtain approval from NTU-IRB and MOH prior to commencement of research. ​