BS6217 - Advanced Synthetic Biology

Summary of co​urse content

This course is the specialization electives for the Biotechnology track and will introduce traditional biological systems in combination with bioengineering approaches and synthetic designs for various applications in diverse fields. A number of state-of-the-art experimental and computational enabling tools for advanced synthetic biology will be introduced. In particular, how to make these biological designs in a concept of synthetic biology will be the core content.

The course is conducted in Technology-Enhanced Learning format, which involves multimedia presentations, Quizzes, videos/short movies. Industries relevant to fermentation/bioreactor, water treatment, waste food treatment etc. (like Anaergia Singapore) are planned to be involved. We will have invited speakers from the company as well as students will be visiting on site.

Rationale for introducing this course

The era of synthetic biology has arrived, and Singapore has also emphasized this trend, and currently is putting more efforts to develop this field. As a course of advance synthetic biology, it would offer a systematic and integrated framework on how the complexity of biological systems in combination with traditional engineering approaches leads to the emergence of new design principles which ultimately make utilitarian goals. So this course allows student to generate a concept in synthetic design towards broad applications in medical, chemical, food and agricultural industries.

Aims and objectives

  • To learn the key enabling tools for synthetic biology as well as to use these tools for some design
  • To explore those highly promising designs and industrial applications in advanced synthetic biology
  • To equip student with concept and idea on how traditional engineering knowledge benefits industrial application
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    Syllabus

  • Nucleotide synthesis and gene assembly for synthetic design
  • Protein engineering and computational protein design
  • Pathway engineering and synthetic strain design
  • Bioreactor, bio-fermentation, and downstream bioprocessing for synthetic biology
  • Synthetic biology designs and applications
  • Synthetic microbial consortia and further perspective
  • Synthetic biology in Singapore (water/waster treatment, bioremediation, and biomaterials)
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    Assessment

    Assignment (a short essay based on journal study)
    Individual30%
    Quiz (questions to be answered and tasks to be finished)
    Individual40%
    Participation (group presentation and discussion)Individual10%
    Group presentationGroup20%
    Total 100%

     

    ​​​Hours of Contact/ Academic Units: 39 hours / 3 AU

    Instructor and Co-instructor (if any):

    • Assoc Prof Gao Yonggui (Course Coordinator)
    • Asst Prof Guillaume Thibault

    Class size: No limit