Recent-Publications

2025

Feel free to read the most recent research publications from LKCMedicine's researchers below.

AGRAWAL, Rupesh

 

BIFANI, Pablo

 

CHEN, Peng

 

CHIA, Po Ying

 

CHOTIRMALL, Sanjay

 

CLELAND, Jennifer

 

CZARNY, Bertrand

 

EMERY, Jon

 

FAN, Eugene

 

GOH, Wilson / LEE, Jimmy

 

GRIVA, Konstadina

 

LEE, Bernett

 

LIM, Jue Tao

 

LIM, Su Chi

 

LIM, Wee Shiong

 

LUO, Dahai

 

MANSKI-NANKERVIS, Jo-Anne / EMERY, Jon

 

NAIR, Aditya

 

NGEOW, Joanne

 

NG, Olivia

 

RUTTER, Guy

 

SAMOL, Jens

 

SCHULZ, Peter

 

SHEN, Xiaotao

 

SUNG, Joseph / WONG, Sunny / GOH, Wilson

 

TAN, Cher Heng

 

TAN, Emmanuel

 

TIEW, Pei Yee / CHOTIRMALL, Sanjay

 

VERMA, Navin

 

WONG, Sabrina

 

WONG, Sunny

 

YAO, Liang

 

YEO, Tianrong

 


AGRAWAL, Rupesh

 

ANG, Shannon

 

CARNEY, Tom

 

CHIA, Po Ying / LIM, Jue Tao / LYE, David / TAN, Bryan / LEO, Yee Sin

 

CHOTIRMALL, Sanjay / TIEW, Pei Yee

 

CHOW, Angela

 

CLELAND, Jennifer

 

DALAN, Rinkoo

 

EMERY, Jon

 

GRIVA, Konstadina

 

KANDIAH, Nagaendran

 

KUIPERS, Ernst

 

LEE, Bernett / RENIA, Laurent

 

LEE, Jimmy

 

LEOW, Melvin

 

LIM, Jue Tao / LYE, David / TAN, Bryan

 

LIM, Su Chi

 

LIM, Wee Shiong

 

LING, Xing Yi

 

LUO, Dahai

 

MANSKI-NANKERVIS, Jo-Anne

 

NGEOW, Joanne

 

NG, Olivia

 

PERUMAL, Vivek

 

PU, Kanyi

 

RUTTER, Guy

 

SADARANGANI, Sapna

 

SCHULZ, Peter

 

SUBRAMANIAM, Mythily

 

TAN, Nguan Soon

 

TAN, Emmanuel / VALLABHAJOSYULA, Ranganath

 

YAO, Liang

 

YEO, Tianrong

 

YUSUF ALI / WONG, Sunny


AGRAWAL, Rupesh

CHAMBERS, John

CHIA, Po Ying

CHOTIRMALL, Sanjay

LEE, Jimmy

LIM, Su Chi

LYE, David

NG, Oon Tek

NGEOW, Joanne

SUNG, Joseph / WONG, Sunny

TAN, Andrew

ZHANG, Melvyn

AGRAWAL, Rupesh

ANDREW TAN / LING XING YI

ANDREA PAVESI

BERNETT LEE

CHAMBERS, John

CHIA, Po Ying

CHOTIRMALL, Sanjay

CLELAND, Jennifer / KITTO, Simon

DALAN, Rinkoo / WENG, Yew Yik / BEST, James / LEE, Jimmy / LEE, Eng Sing / NGEOW, Joanne / LI, Guan Xue / LOH, Marie / CHAMBERS, John

GUY RUTTER

JOSEPH SUNG

JOACHIM LOO / WONG, Sunny

KANDIAH, Nagaendran

LEE, Bernett / AGRAWAL, Rupesh

LEOW, Melvin

LIANG, Kun

LIANG, Yao

LIM, Jue Tao

LIM, Tock Han

LUO, Dahai

LYE, David / GHANI, Azra

PU, Kanyi

VERMA, Navin

WONG, Sunny

YUSUF ALI / RUTTER, Guy / LEE, Bernett

I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression

AGRAWAL, Rupesh

ANG, Shannon

BARRON, Anna / KANDIAH, Nagaendran

CHAN, Alvin

CHAMBERS, John

CHOTIRMALL, Sanjay

CLELAND, Jennifer

EJIMA, Keisuke / LYE, David / YOUNG, Barnaby / LIM, Jue Tao / CHIA, Po Ying

EJIMA, Keisuke / CHIA, Po Ying

FAN, Xiuyi

HAN, Siew Ping / NG, Olivia

HUANG, Hen-Wei

KANDIAH, Nagaendran

KUSUMBE, Anjali

LIANG, Yao

LING, Xing Yi

LUO, Dahai

LYE, David

NG, Adeline

PU, Kanyi

RAMADAN, Kristijan

RENIA, Laurent

RUTTER, Guy

SAHEKI, Yasunori

SUNG, Joseph

YU, Baosheng

AGRAWAL, Rupesh / LEE, Bernett A decade-long review: insights into diagnosis and disease evolution of uveitis from a single-center study

CHOTIRMALL, Sanjay Longitudinal analysis of lung microbiome, immune response, and metabolism in ventilator-associated pneumonia: a cohort study

GOH, Wilson / SUNG, Joseph A Model Predicting Artificial Intelligence Use by Gastroenterology Nurses in Clinical Practice: A Cross-Sectional Multicenter Survey

KANDIAH, Nagaendran / CHEUNG, Christine Chronic cerebral hypoperfusion induces venous dysfunction via EPAS1 regulation in mice

LEOW, Melvin Integration of metabolomics and machine learning for precise management and prevention of cardiometabolic risk in Asians

LIM, Su Chi Methylamine metabolites and progression to kidney failure in type 2 diabetes: An Asian and European prospective study

RAMADAN, Kristijan The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

SUNG, Joseph Theory-based chatbot for promoting colorectal cancer screening in a community setting in Hong Kong: study protocol of a randomised controlled trial

TAN, Andrew / XING, Ling Yi Transfer Learning-Assisted SERS: Predicting Molecular Identity and Concentration in Mixtures Using Pure Compound Spectra

WONG, Sunny Effects of Prebiotics Inulin and Oat β-Glucan on Colonic Architecture and Hepatic Proteome in Mice with Circadian-Disruption-Aggravated Metabolic Dysfunction-Associated Steatohepatitis

Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut

AGRAWAL, Rupesh / LEE, Bernett Validation of the COTS Calculator for Tubercular Uveitis: Predictive Performance and Diagnostic Utility in an Indian Cohort

BARRON, Anna / WANG, Yulan Age-Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

CARNEY, Tom Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage

CHOTIRMALL, Sanjay / TIEW, Pei Yee Ethnic variation in South East Asian patients with severe asthma: A first look at the Singapore Severe Asthma Registry (SSAR) and implications on clinical practice

CHOTIRMALL, Sanjay Antimicrobial Resistance and Pathobionts in Bronchiectasis: An Old Problem for a New Era? Using the 2024 NASEM Definition of Long COVID: Implications for Pulmonary and Critical Care Medicine

DALAN, Rinkoo Barriers and facilitators of physical activity and exercise among adults with type 2 diabetes mellitus in Singapore – A mixed-methods sequential explanatory study mapped to the COM-B model, theoretical domains framework and behavioural change wheel

JUE TAO, Lim / BARNABY, Young / LYE, David Remdesivir and risk of multi-systemic long-term sequelae following COVID-19 hospitalisation

JUE TAO, Lim / LYE, David Characterization of post-acute multi-organ sequelae following dengue infection Long-term multi-systemic sequelae post-hospitalization for Omicron COVID-19 versus influenza: a retrospective cohort study

JUE TAO, Lim / EJIMA, Keisuke Modelling the potential spread of Clade Ib MPXV in Asian cities

KUSUMBE, Anjali Lymphatic-immune interactions in the musculoskeletal system

LEE, Bernett / AGRAWAL, Rupesh Validation of the COTS Calculator for Tubercular Uveitis: Predictive Performance and Diagnostic Utility in an Indian Cohort (duplicate)

LEOW, Melvin Fatty Acylcarnitine Metabolism in Brown/Beige and White Fats by 13C HRMAS NMR Spectroscopy With Metabolic Interventions

LI, Guan Xue Endogenous formation of phosphatidylhomoserine in Escherichia coli through phosphatidylserine synthase

LIM, Kah Leong Imaging advances to detect non-motor prodromal markers of Parkinson's disease and explore therapeutic translation opportunities

LIM, Su Chi

Growth-differentiation factor 15 (GDF-15) is associated with arterial stiffness and impaired endothelial function with mediation by albuminuria in the Singapore study of macroangiopathy and microvascular reactivity in type 2 diabetes (SMART2D) cohort

LIANG, Yao Efficiency must not compromise trustworthiness in rating certainty and formulating recommendations in AI era Core GRADE 7: principles for moving from evidence to recommendations and decisions

LOH, Marie / RENIA, Laurent / LYE, David / YOUNG, Barnaby Novel NUDCD1 gene variant predisposes to severe COVID-19 disease in Asians through modulation of antiviral DHX15- and MAVS-mediated signalling

LUO, Dahai 1H, 15N and 13C backbone resonance assignment of the N-terminal region of Zika virus NS4B protein in detergent micelles

MANSKI-NANKERVIS, Jo-Anne Implementation of a Quality Improvement and Clinical Decision Support Tool for Cancer Diagnosis in Primary Care: Process Evaluation

NGEOW, Joanne Identifying the unmet needs of patients with neurofibromatosis type 1 in Singapore

PETHE, Kevin / CHAN, Mary A cationic main-chain poly(carbonate-imidazolium) potent against Mycobacterium abscessus and other resistant bacteria in mice (duplicate)

RAMASAMY, Saravana / VERMA, Navin / CHEUNG, Christine / KUSUMBE, Anjali Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment

SAMOL, Jens Asia Pacific Gastroesophageal Cancer Congress (APGCC) 2024 consensus statement on stage 2 and 3 locally advanced gastric and Siewert 3 junctional adenocarcinoma

SUBRAMANIAM, Mythily Perceived risk of illicit drug consumption in singapore: findings from a nationwide survey

SUN, Joseph / WONG, Sunny Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

SUN, Joseph A magnetically actuated microcatheter with soft rotatable tip for enhanced endovascular access and treatment efficiency

TAN, Andrew / GOH, Wilson Glioportal: a comprehensive transcriptomic resource unveiling ligand-mediated mesenchymal transition in glioblastoma

TAN, Andrew Advancements and Challenges in Modeling Mechanobiology in Intestinal Host-Microbiota Interaction Non-viral, high throughput genetic engineering of primary immune cells using nanostraw-mediated transfection

YAP, Eric Genome sequences of Acinetobacter phage At2 and its host Acinetobacter tandoii W4-4-4

YU, Baosheng MIFNet: Learning Modality-Invariant Features for Generalizable Multimodal Image Matching

 

AGRAWAL, Rupesh The Global Epidemiology of Scleritis: A Systematic Review and Meta-analysis

CHAN, Mary / PETHE, Kevin A cationic main-chain poly(carbonate-imidazolium) potent against Mycobacterium abscessus and other resistant bacteria in mice

CHAMBERS, John Compliance to tobacco and alcohol zoning regulations around schools in Bangladesh, India, Pakistan and Sri Lanka using environmental mapping data

CHAMBERS, John / LOH, Marie / CHEUNG, Christine / NGEOW, Joanne / LEE, Jimmy / LEE, Eng Sing / DALAN, Rinkoo / BEST, James Metabolome-wide association identifies ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations

CHEUNG, Christine / KUSUMBE, Anjali / RAMASAMY, Saravana / VERMA, Navin Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment

CHEW, Sing Yian Bioprinted Microchannel Scaffolds Modulate Neuronal Differentiation of Encapsulated Human Spinal Cord Progenitor Cells

DALAN, Rinkoo Barriers and facilitators of physical activity and exercise among adults with type 2 diabetes mellitus in Singapore – A mixed-methods sequential explanatory study mapped to the COM-B model, theoretical domains framework and behavioural change wheel

FAN, Xiuyi / SUBRAMANIAM, Mythily / WONG, Sunny The Gut Microbiota in Young Adults with High-Functioning Autism Spectrum Disorder and Its Performance as Diagnostic Biomarkers

FOO, Jia Nee Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson's disease

KANDIAH, Nagaendran Current status and future directions for the diagnosis and management of mild cognitive impairment in Southeast Asia: A SEACURE consensus paper

KONG, Keng He / TAN, Bryan / LIM, Wee Shiong / CHUA, Karen Targeting osteosarcopenia and multimorbidity for frailty prevention through identification and deep phenotyping methods in healthy ageing and high-burden disease cohorts (OPTIMA-C)

LEE, Eng Sing / WONG, Sabrina A person-centred Healthier SG outcomes framework

LI, Guan Xue Endogenous formation of phosphatidylhomoserine in Escherichia coli through phosphatidylserine synthase

LIM, SU Chi Plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) and the risk of chronic kidney disease progression in patients with type 2 diabetes

Double product is longitudinally associated with reduced cognitive function in type 2 diabetes with insights from cross-lagged panel analysis and mediation by leucine-rich α-2-glycoprotein 1 Urine choline oxidation metabolites predict chronic kidney disease progression in patients with type 2 diabetes

LIM, Wee Shiong The impact of lifestyle factors across the life course on sarcopenia and physical frailty

LUO, Dahai Saddle curvature association of nsP1 facilitates the replication complex assembly of Chikungunya virus in cells

LYE, David / EJIMA, Keisuke / RENIA, Laurent / YOUNG, Barnaby / CHIA, Po Ying / YEO, Tsin Wen Early neutrophil responses are potential biomarkers to predict severe COVID-19 in adults

NG, Adeline Clinical characteristics of pathological confirmed DLB without parkinsonism

PETHE, Kevin Unprecedented in vivo activity of telacebec against Mycobacterium leprae

RENIA, Laurent SARS-CoV-2: lessons in virus mutation prediction and pandemic preparedness The role of periostin (OSF-2) in the cytoadherence phenomena mediated by malaria parasites

SAMOL, Jens Early Lung Cancer Patient Journey in Singapore: Challenges and Recommendations

SUBRAMANIAM, Mythily Perceived risk of illicit drug consumption in Singapore: findings from a nationwide survey

SUNG, Joseph Expert of Experts Verification and Alignment (EVAL) Framework for Large Language Models Safety in Gastroenterology PM2.5-Associated Premature Mortality Attributable to Hot-And-Polluted Episodes and the Inequality Between the Global North and the Global South Mosquito and global dengue cases in a warming world

YAO, Liang Anti-TIGIT inhibitors plus PD-1 or PD-L1 inhibitors for advanced non-small cell lung cancer

YEO, Tianrong Neurological Sweet's syndrome: a rare but treatable manifestation of an autoinflammatory disease

AGRAWAL, Rupesh / LEE, Bernett

APFELBACHER, Christian / YEW, Yik Weng

BAOSHENG, Yu

CHAMBERS, John

CHIA, Po Ying

CHEUNG, Christine / KUSUMBE, Anjali / RAMASAMY, Saravana / VERMA, Navin

CLELAND, Jennifer

CLELAND, Jennifer / HAN, Siew Ping / NG, Olivia

CLELAND, Jennifer / NG, Olivia / LEE, Zheng-Wei

GRIVA, Konstadina

HAN, Siew Ping / MOGALI, Reddy

LEE, Jimmy

LEOW, Melvin

LIM, Jue Tao / LIM, Su Chi / LYE, David

NG, Olivia

PETHE, Kevin

PU, Kanyi

SUBRAMANIAM, Mythily

SUNG, Joseph / WONG, Sunny

YA0, Liang

YOUNG, Barnaby

 

AGRAWAL, Rupesh

BAOSHENG, Yu

BECKER, David

CHAMBERS, John / LOH, Marie / PRABHAKAR, Shyam

CHEUNG, Christine

CHOTIRMALL, Sanjay / TIEW, Pei Yee

CHOW, Angela

CLELAND, Jennifer

DALAN, Rinkoo

DUAN, Hongwei

EJIMA, Keisuke / LIM, Jue Tao

EJIMA, Keisuke / LYE, David / YOUNG, Barnaby

FOO, Jia Nee

FOO, Jia Nee / NG, Adeline

GOH, Wilson

GRIVA, Konstadina

GULYAS, Balazs

KANDIAH, Nagaendran

LEE, Jimmy

LEE, Eng Sing

LIM, Jue Tao / LYE, David

LIM, Jue Tao

LIM, Su Chi

LOH, Marie

LEOW, Melvin / LIM, Su Chi

MANSKI-NANKERVIS, Jo-Anne

NGEOW, Joanne / WONG, Sabrina

NGEOW, Joanne / YEO, Si Yong

NGUYEN, Michele

PANG, Tan Chin Hong

PU, Kanyi

RENIA, Laurent

SUNG, Joseph

SUNG, Joseph / WONG, Sunny

SUBRAMANIAM, Mythily

TAN, Boon Huan

TEY, Hong Liang

YAO, Liang

YEO, Si Yong

CHOTIRMALL, Sanjay

CHOW, Angela

CHEUNG, Christine / KANDIAH, Nagaendran

CLELAND, Jennifer

GOH, Wilson / LEE, Jimmy

GRIVA, Konstadina

GRIVA, Konstadina / SUBRAMANIAM, Mythily

KANDIAH, Nagaendran / CHEUNG, Christine

LEE, Bernett

LEE, Bernett / WANG, Yulan

LIM, Jue Tao

MANSKI-NANKERVIS, Jo-Anne

PAVESI, Andrea

PETHE, Kevin / WONG, Christine

RENIA, Laurent

SAHEKI, Yasunori

TAN, Andrew / WANG, Yulan

WANG, Yulan / TAN, Ern Yu

VERMA, Navin / CHANDY, George

YAO, Liang

ZHONG, Franklin

 

CHAMBERS, John

CHAMBERS, John / LOH, Marie / YEW, Yik Weng

CHEW, Sing Yian

CHOTIRMALL, Sanjay / TIEW, Pei Yee

CLELAND, Jennifer

EJIMA, Keisuke

EJIMA, Keisuke / LYE, David / YOUNG, Barnaby

FOO, Jia Nee

GOH, Wilson

GRIVA, Konstadina / WONG, Sabrina / SMITH, Helen / LIM, Su Chi

HAN, Siew Ping

KAMIGAKI, Tsukasa

KANDIAH, Nagaendran

KASAHARA, Kazuyuki

LEE, Bernett / LEE, Jimmy

LIM, Kah Leong

MANSKI-NANKERVIS, Jo-Anne

NGEOW, Joanne

RENIA, Laurent

SAHEKI, Yasunori

SUNG, Joseph

VALLABHAJOSYULA, Ranganath

WONG, Sunny