2021

Rupesh AGRAWAL

• Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography.
• Global Preferred Practice Patterns for the Management of Exogenous Endophthalmitis: A Survey by the American Society of Ophthalmic Trauma.
• The Eye of the Storm: COVID-19 Vaccination and the Eye.
• Eye Care During the COVID-19 Pandemic: A Report on Patients' Perceptions and Experiences, an Asian Perspective.
• Clinical characteristics and treatment outcomes of Cytomegalovirus anterior uveitis and endotheliitis: a systematic review and meta-analysis.

• Colorimetric and Fluorometric Profiling of Advanced Glycation End Products.

• Traversing Boundaries: New Digital Project to Study Drugs in Asian History by Yan Liu.

• Experiences, opinions and expectations of health care providers towards an intensive care unit follow-up clinic: Qualitative study and online survey.

• Vitamin D Supplementation and Cognition in Adults: A Systematic Review of Randomized Controlled Trials.
• Effects of Memantine and High Dose Vitamin D on Gait in Male APP/PS1 Alzheimer's Disease Mice Following Vitamin D Deprivation.

• Conversational Agent for Healthy Lifestyle Behavior Change: Web-Based Feasibility Study.

• Health-related quality of life and chronic wound characteristics among patients with chronic wounds treated in primary care: A cross-sectional study in Singapore.

• Complex Lifestyle and Psychological Intervention in Knee Osteoarthritis: Scoping Review of Randomized Controlled Trials.

• Delphi Consensus on American Society of Anesthesiologists' Physical Status Classification in an Asian Tertiary Women's Hospital.

• Meta-analyses identify DNA methylation associated with kidney function and damage.
• The power of genetic diversity in genome-wide association studies of lipids.

• The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial.

• Reverse-translational identification of a cerebellar satiation network.
• Sex-specific accelerated decay in time/activity-dependent plasticity and associative memory in an animal model of Alzheimer's disease.

• Neural Cell Membrane-Coated Nanoparticles for Targeted and Enhanced Uptake by Central Nervous System Cells.

• Comparing hospital-resource utilization by an enhanced pneumonia surveillance programme for COVID-19 with pre-pandemic pneumonia admissions - a Singaporean hospital's experience.
• The first nosocomial cluster of COVID-19 due to the Delta variant in a major acute-care hospital in Singapore - investigations and outbreak response.
• Sociodemographic and clinical factors, visit expectations and driving factors for emergency department attendance for uncomplicated upper respiratory tract infection.
• Antibiotic Expectations of Emergency Department Patients with Upper Respiratory Tract Infections: Clinical and Antibiotic Use Behavioral Determinants.

• When I say … privilege.
• The do's, don'ts and don't knows of redressing differential attainment related to race/ethnicity in medical schools.

• Noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the risk of malignancy in thyroid cytology: Data from Singapore.

• A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array.

• Technological advancements in the assessment and intervention of developmental disabilities.
• Clarifying the relationship between alexithymia and subjective interception.

• Treatment-related decisional conflict in pre-dialysis chronic kidney disease patients in Singapore: Prevalence and determinants.
• The Interplay Between Strictness of Policies and Individuals' Self-Regulatory Efforts: Associations with Handwashing During the COVID-19 Pandemic.

• Neural correlates of state transitions elicited by a chemosensory danger cue.

• Comparative study of emotion recognition and theory of mind between major depressive disorder and schizophrenia.

• Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

• Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo.

• Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.

• Investigator-Driven Randomised Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare-Associated and Hospital-Acquired Gram-negative Bloodstream Infection: Study protocol (the GAME CHANGER trial): study protocol for an open-label, randomised controlled trial.

• Impact of Delta Variant and Vaccination on SARS-CoV-2 Secondary Attack Rate Among Household Close Contacts.

• Understanding patients' views and willingness toward the use of telehealth in a cancer genetics service in Asia.
• Germline breast cancer susceptibility genes, tumor characteristics, and survival.

• Learning to diagnose X-rays: a neuroscientific study of practice-related activation changes in the prefrontal cortex.

• Aberrant Wnt Signaling Induces Comedo-Like Changes in The Murine Upper Hair Follicle.

• Micro-/Nanorobots in Antimicrobial Applications: Recent Progress, Challenges, and Opportunities.

• Trends in Incidence and Clinical Outcomes of Clostridioides difficile Infection, Hong Kong.

• Bioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics.

• In Vivo Efficacy of Neutrophil-Mediated Bone Regeneration Using a Rabbit Calvarial Defect Model.
• Marine collagen scaffolds in tissue engineering.

• Skin-ny deeping: Uncovering immune cell behavior and function through imaging techniques.
• Systemic inflammatory reactions after COVID-19 vaccinations: Consider the diagnosis of ASIA.

• GSK3β Interacts With CRMP2 and Notch1 and Controls T-Cell Motility.

• RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE.

• Insights into potential causes of vascular hyperpermeability in dengue.
• Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial.

• The Historical Evolution of Ocular Tuberculosis: Past, Present, and Future.
• The application of clinical registries in ophthalmic trauma-the International Globe and Adnexal Trauma Epidemiology Study (IGATES).
• Redefining response in wet AMD to anti VEGF therapy based on non-OCTA versus OCTA evaluation.

• Robotic-based ACTive somatoSENSory (Act.Sens) retraining on upper limb functions with chronic stroke survivors: study protocol for a pilot randomised controlled trial.

• Frequency of hand eczema in the elderly - cross-sectional findings from the German AugUR study.

• A wireless and battery-free wound infection sensor based on DNA hydrogel.

• COVID-19 and metabolic disease: mechanisms and clinical management.

• The importance of air quality for underground spaces: An international survey of public attitudes.
• Revisiting the four core functions (4Cs) of primary care: operational definitions and complexities.

• Label-free quantitative measurement of cardiovascular dynamics in a zebrafish embryo using frequency-comb-referenced-quantitative phase imaging.
• Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration.

• Corrigendum: Elena+ Care for COVID-19, a Pandemic Lifestyle Care Intervention: Intervention Design and Study Protocol.

• Effects of a lifestyle intervention programme after 1 year of follow-up among South Asians at high risk of type 2 diabetes: a cluster randomised controlled trial.

• A Parametric Framework to Generate Visual Illusions Using Python.

• Cellular Features Revealed by Transverse Laser Modes in Frequency Domain.

Sanjay CHOTIRMALL

• The current understanding and future directions for sputum microbiome profiling in chronic obstructive pulmonary disease.

• Mathematical-based microbiome analytics for clinical translation.

• Psychological impact of repeated epidemic exposure on healthcare workers: findings from an online survey of a healthcare workforce exposed to both SARS (severe acute respiratory syndrome) and COVID-19.

• Hospital Pharmacists and Antimicrobial Stewardship: A Qualitative Analysis.

• A cross-sectional study examining MRCS performance by core surgical training location.
• Implementing change: Intervention development.
• Even a little sleepiness influences neural activation and clinical reasoning in novices.

• Cameras on or off: What is the question?

• Professional development during the COVID-19 pandemic: Crisis or opportunity?

• Reduced Perceived Trustworthiness during Face Mask Wearing.
• Surveying 80 Years of Psychodrama Research: A Scientometric Review.
• I'm alone but not lonely. U-shaped pattern of self-perceived loneliness during the COVID-19 pandemic in the UK and Greece.

• Evaluating Rates and Determinants of COVID-19 Vaccine Hesitancy for Adults and Children in the Singapore Population: Strengthening Our Community's Resilience against Threats from Emerging Infections (SOCRATEs) Cohort.

• Public Perceptions of Diabetes, Healthy Living, and Conversational Agents in Singapore: Needs Assessment.

• The bacterial tyrosine kinase system CpsBCD governs the length of capsule polymers.

• Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA).

• Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease.
• Alzheimer's Disease THErapy With NEuroaid (ATHENE): A Randomized Double-Blind Delayed-Start Trial.

• Clinical- and omics-based models of subclinical atherosclerosis in healthy Chinese adults: a cross-sectional exploratory study.
• Branched Chain Amino Acid Supplementation to a Hypocaloric Diet Does Not Affect Resting Metabolic Rate but Increases Postprandial Fat Oxidation Response in Overweight and Obese Adults after Weight Loss Intervention.

• Viral dynamics and immune correlates of COVID-19 disease severity.
• Correction to: Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection.
• Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study.
• Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals.

• Lack of viable SARS-CoV-2 among PCR-positive air samples from hospital rooms and community isolation facilities.

• Author Correction: PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein.
• Impact of Variant Reclassification in Cancer Predisposition Genes on Clinical Care.

• The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in Mycobacterium abscessus.

• Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies.

• Renal-Clearable Molecular Probe for Near-Infrared Fluorescence Imaging and Urinalysis of SARS-CoV-2.

• Plasmodium falciparum rosetting protects schizonts against artemisinin.

• Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes.
• Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study.

• Correction to: A mobile swabbing booth to address Singapore GPs' concerns about swabber protection: human-centred design during the COVID-19 pandemic.
• Experiences of doctors working in Singapore's public primary healthcare clinics.
• Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

• Priorities for family physician and general practitioner recruitment and retention in Singapore: a PRIORITIZE study.

• Inherited skin disorders presenting with poikiloderma.

• Circulating microRNA Breast Cancer Biomarker Detection in Patient Sera with Surface Plasmon Resonance Imaging Biosensor.

• Chelating Phosphine-N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines.

• Non-Bullous Pemphigoid: A Yet-to-Be Defined Disease Entity.
• Response to: Momen et al's "Discriminating minor and major forms of drug reaction with eosinophilia and systemic symptoms: Facial edema aligns to the severe phenotype".

• The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling.

• Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy.

• Malaria in Pregnancy: From Placental Infection to Its Abnormal Development and Damage.

• Bilateral Pupillary Involvement as a Clinical Presentation of Herpes Zoster Ophthalmicus.
• Myopic Shift in a Patient with Dengue Fever.

• Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial.

• Microglia and CD206 + border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease.

• Emergency room evaluation and recommendations for older emergency department users: results of the ER 2 experimental study.

• Extracellular matrix and cellular senescence in venous leg ulcers.
• Development of a refined ex vivo model of peritoneal adhesion formation, and a role for connexin 43 in their development.

• Thrombosis post COVID-19 vaccinations: Potential link to ACE pathways.

• Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018.
• Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling.
• Health, Lifestyle, and Psycho-Social Determinants of Poor Sleep Quality During the Early Phase of the COVID-19 Pandemic: A Focus on UK Older Adults Deemed Clinically Extremely Vulnerable.

• Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050.
• Global, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019.

• Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals.

• Scaffold-Based Delivery of CRISPR/Cas9 Ribonucleoproteins for Genome Editing.

• Respiratory Mycoses in COPD and Bronchiectasis.
• Respiratory Mycoses: A Call to Action to Recognize, Educate and Invest.
• Treatment Trials in Young Patients with COPD and Pre-COPD Patients: Time to Move Forward.

• Exploring antibiotic prescribing in public and private primary care settings in Singapore: a qualitative analysis informing theory and evidence-based planning for value-driven intervention design.

• The curious case of case study research.
• Using time wisely - Aligning ice breakers with the objective of a session.

• Developmental disabilities across the world: A scientometric review from 1936 to 2020.
• Father-child dyads exhibit unique inter-subject synchronisation during co-viewing of animation video stimuli.
• Reproducible Inter-Personal Brain Coupling Measurements in Hyperscanning Settings With functional Near Infra-Red Spectroscopy.

• The trajectory of COVID-19 pandemic and handwashing adherence: findings from 14 countries.
• A Multiethnic Asian Perspective of Presumed Consent for Organ Donation: A Population-Based Perception Study.

• How doppelgänger effects in biomedical data confound machine learning.

• Amyloid Beta42 (Aβ42) Peptide Functionalized Iron Oxide Nanoparticles for Specific Targeting of SH-SY5Y Neuroblastoma Cells.
• Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography.
• Multimedia-Based Learning Tools and Its Scope, Applications for Virtual Learning Environment.

• A Novel Mindful-Compassion Art-Based Therapy for Reducing Burnout and Promoting Resilience Among Healthcare Workers: Findings From a Waitlist Randomized Control Trial.

• Musculoskeletal regeneration: A zebrafish perspective.

• Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals.
• Altered Cerebrospinal Fluid Exosomal microRNA Levels in Young-Onset Alzheimer's Disease and Frontotemporal Dementia.

• Associations of living arrangements with symptoms and functioning in schizophrenia.
• Evaluating the utility of digital phenotyping to predict health outcomes in schizophrenia: protocol for the HOPE-S observational study.

• A Cross-Sectional Study of the Clinical Metrics of Functional Status Tools in Pediatric Critical Illness.
• Influence of red blood cell indices on HbA1c performance in detecting dysglycaemia in a Singapore preconception cohort study.
• A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.

• Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging.

• The role of pulse pressure in navigating the paradigm of chronic kidney disease progression in type 2 diabetes mellitus.

• Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.

• Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors.
• Differentiating coronavirus disease 2019 (COVID-19) from influenza and dengue.

• Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients.

• Is Virtual Team-Based Learning Feasible and Effective in Teaching Neurolocalisation?

• A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection.

• Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore.

• Resistance of SARS-CoV-2 Delta variant to neutralization by BNT162b2-elicited antibodies in Asians.

• The role of gut dysbiosis in Parkinson's disease: mechanistic insights andtherapeutic options.

• Virtual Clinical Encounter Examination (VICEE): A novel approach for assessing medical students' non-psychomotor clinical competency.

• A Validated Instrument Measuring Students' Perceptions on Plastinated and Three-Dimensional Printed Anatomy Tools.

• PDZD-8 and TEX-2 regulate endosomal PI(4,5)P 2 homeostasis via lipid transport to promote embryogenesis in C. elegans.
• Regulation of plasma membrane sterol homeostasis by non-vesicular lipid transport.
• Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.

• Examining the Trends in Online Health Information-Seeking Behavior About Chronic Obstructive Pulmonary Disease in Singapore: Analysis of Data From Google Trends and the Global Burden of Disease Study.

• Cutibacterium acnes: much ado about maybe nothing much.

• What is unknown in using Microbiota as a Therapeutic?

• DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.

• Progress and Challenges in Quantifying Carbonyl-Metabolomic Phenomes with LC-MS/MS.

• Acute Isolated Near Vision Difficulty in Patients With COVID-19 Infection
• Vogt-Koyanagi-Harada Disease Associated with COVID-19 mRNA Vaccine.
• Ocular Adverse Events After COVID-19 Vaccination

• Relationship of low molecular weight fluorophore levels with clinical factors and fenofibrate effects in adults with type 2 diabetes

• Tracking development assistance for health and for COVID-19: a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050.

• APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups

• Respiratory Mycoses: A Call to Action to Recognize, Educate and Invest

• Accuracy of a rapid multiplex PCR plus a chromogenic phenotypic test algorithm for detection of ESBL and carbapenemase-producing Gram-negative bacilli in positive blood culture bottles

• Extracellular vesicles in cardiovascular disease

• Parental Quality of Life and Involvement in Intervention for Children or Adolescents with Autism Spectrum Disorders: A Systematic Review

• Effectiveness of a brief positive skills intervention to improve psychological adjustment in patients with end-stage kidney disease newly initiated on haemodialysis: protocol for a randomised controlled trial (HED-Start)

• Gold Nano-Urchins Enhanced Surface Plasmon Resonance (SPR) BIOSENSORS for the Detection of Estrogen Receptor Alpha (ERα) 
• Alzheimer's Disease: A Molecular View of β-Amyloid Induced Morbific Events

• A Randomized Waitlist-Controlled Trial of an Intergenerational Arts and Heritage-Based Intervention in Singapore: Project ARTISAN.

• Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals

• Comparative study of emotion recognition and theory of mind between major depressive disorder and schizophrenia

• Clinical- and omics-based models of subclinical atherosclerosis in healthy Chinese adults: a cross-sectional exploratory study.

• Lewy-body Like Inclusions in Human Midbrain Organoid Carrying Glucocerebrosidase and Alpha Synuclein Mutations 
• Activation of Autophagy Ameliorates Age-Related Neurogenesis Decline and Neurodysfunction in Adult Mice

• Global haemostatic tests demonstrate the absence of parameters of hypercoagulability in non-hypoxic mild COVID-19 patients: a prospective matched study

• The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in Mycobacterium abscessus.

• Industrially Compatible Transfusable iPSC-Derived RBCs: Progress, Challenges and Prospective Solutions

• INPP5K and Atlastin-1 maintain the nonuniform distribution of ER-plasma membrane contacts in neurons.

• A mobile swabbing booth to address Singapore GPs' concerns about swabber protection: human-centred design during the COVID-19 pandemic

• Activated natural killer cell promotes non-alcoholic steatohepatitis through mediating JAK/STAT pathway

• Timing of endoscopy for acute upper gastrointestinal bleeding: a territory-wide cohort study

• Bioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics

• Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility

• Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

• GALAXY Workflow for Bacterial Next-Generation Sequencing De Novo Assembly and Annotation
• Trapping and Detection of Single Viruses in an Optofluidic Chip

• The International Globe And Adnexal Trauma Epidemiology Study Igates. Global Current Practice Patterns for the Management of Open Globe Injuries

• Enhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial.
• Sucrose Esters: Potent and Selective Inhibitors of α-glucosidase and α-amylase

• Risk for short-term undesirable outcomes in older emergency department users: Results of the ER2 observational cohort study

• Cx43 mediates changes in myofibroblast contraction and collagen release in human amniotic membrane defects after trauma

• Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019
• Identifying topics for future Cochrane Public Health reviews

• HIGH FREQUENCY OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS IN BRONCHIECTASIS-COPD OVERLAP
• Aspergillus-Associated Endophenotypes in Bronchiectasis

• Does performance at medical school predict success at the Intercollegiate Membership of the Royal College of Surgeons (MRCS) examination? A retrospective cohort study

• OXTR moderates adverse childhood experiences on depressive symptoms among incarcerated males
• Influences of Social Distancing and attachment styles on the strength of the Halo Effect.
• Father-child dyads exhibit unique inter-subject synchronisation during co-viewing of animation video stimuli

• Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy
• Mn 2+ -Phos-Tag Polyacrylamide for the Quantification of Protein Phosphorylation Levels

• Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.

• Cancer caregivers unmet needs and emotional states across cancer treatment phases

• The Effect of Therapeutic Alliance on Attitudes Toward Psychiatric Medications in Schizophrenia

• Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).

• Remdesivir for the prevention of invasive mechanical ventilation or death in COVID-19 - A post-hoc analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data
• Contemporary narrative review of treatment options for COVID-19
• A vaccination update for rheumatologists-SARS-CoV-2, influenza and herpes zoster
• Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2)

• Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7 (Alpha), B.1.315 (Beta), and B.1.617.2 (Delta)

• Nosocomial infections among COVID-19 patients: an analysis of intensive care unit surveillance data

• DNA methylation and breast cancer-associated variants

• Irritable bowel syndrome and risk of glaucoma: An analysis of two independent population-based cohort studies

• Investigating the effectiveness of three-dimensional printed anatomical models compared to plastinated human specimens in learning cardiac and neck anatomy: A randomized cross-over study
• Exploring the feasibility of using very short answer questions (VSAQs) in team-based learning (TBL).

• Promotion of knowledge transfer and retention in year 2 medical students using an online training exercise

• X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
• Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths
• Children with Plasmodium vivax infection previously observed in Namibia, were Duffy negative and carried a c.136G > A mutation

• Mechanisms of weight loss after obesity surgery
• Intravital imaging of islet Ca 2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice.
• Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study.

• GRAMD1-mediated accessible cholesterol sensing and transport.

• Circulating microRNA Breast Cancer Biomarker Detection in Patient Sera with Surface Plasmon Resonance Imaging Biosensor

• GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
• The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance

• BD metabonomics predicts phenotype, disease course, and treatment response
• Understanding Choline Bioavailability and Utilization: First Step Toward Personalizing Choline Nutrition

• Tracking oxidation-induced alterations in fibrin clot formation by NMR-based methods

• Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

• The United States Eye Injury Registry: past and future directions (Ophthalmology)
• Antiviral Therapy for Varicella Zoster Virus (VZV) and Herpes Simplex Virus (HSV)-Induced Anterior Uveitis: A Systematic Review and Meta-Analysis

• Experiences, opinions and expectations of health care providers towards an intensive care unit follow-up clinic: Qualitative study and online survey

• Feruloyl Sucrose Esters: POTENT AND SELECTIVE INHIBITORS OF α-GLUCOSIDASE AND α-AMYLASE
• Effectiveness of data auditing as a tool to reinforce good research data management (RDM) practice: a Singapore study

• Higher extracellular water to total body water ratio was associated with chronic kidney disease progression in type 2 diabetes. 2021

• Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice

• Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

• Just-in-time Adaptive Mechanisms of Popular Mobile Applications for Individuals with Depression: Systematic Review
• Choice of Behavioral Change Techniques in Health Care Conversational Agents: Protocol for a Scoping Review

• Health literacy and health outcomes in patients with low back pain: a scoping review

• Evaluating the impact of COVID-19 on the adoption of virtual care in general practice in 20 countries (inSIGHT): rationale and study protocol.

• Self-guided Cognitive Behavioral Therapy Apps for Depression: Systematic Assessment of Features, Functionality, and Congruence With Evidence

• Digital Health Training Programs for Medical Students: Scoping Review.

• Intranasal octenidine for methicillin-resistant Staphylococcus aureus (MRSA) carriers and universal octenidine bathing reduced MRSA acquisition in an acute-care general ward.

• Short-term mortality from HIV-infected persons diagnosed from 2012 to 2016: Impact of late diagnosis of HIV infection

• When I say … privilege. 2021. Medical Education.
• Opening up the black box of a Gateway to Medicine programme: a realist evaluation

• Psychometric properties of the thyroid-specific quality of life questionnaire ThyPRO in Singaporean patients with Graves' disease

• Parental involvement in developmental disabilities across cultures. 2021. Research in Developmental Disabilities

• Modulation of Instagram Number of Followings by Avoidance in Close Relationships in Young Adults under a Gene x Environment Perspective

• Effectiveness and acceptability of a multidisciplinary approach in improving the care of patients with advanced chronic kidney disease: a pilot study

• Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.
• FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.

• Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia

• Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis

• Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality

• Lewy-body Like Inclusions in Human Midbrain Organoid Carrying Glucocerebrosidase and Alpha Synuclein Mutations

• Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease

• Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study.

• How practice setting affects family physicians' views on genetic screening: a qualitative study

• Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor.

• Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells
• Rodent Malaria Erythrocyte Preference Assessment by an Ex Vivo Tropism Assay

• Community case managers' challenges collaborating with primary care when managing complex patients in the community: A qualitative study in Singapore

• Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials. 2021. Alimentary Pharmacology & Therapeutics
• Clopidogrel is no better or worse than aspirin when combined with proton pump inhibitors in the prevention of major adverse event. Is the jury out?

• A PDZ Protein GIPC3 Positively Modulates Hedgehog Signaling and Melanoma Growth. 2021. Journal of Investigative Dermatology

• Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices
• Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.

• Single Cell Metabolite Detection Using Inertial Microfluidics-Assisted Ion Mobility Mass Spectrometry

• Draft Genome Sequence of Enterobacter hormaechei subsp. steigerwaltii Strain BEI01

• Frequency of hand eczema in the elderly - cross-sectional findings from the German AugUR study

• Quality of life in atopic dermatitis in Asian countries: a systematic review

• A neural circuit for excessive feeding driven by environmental context in mice.

• Emergency room evaluation and recommendations for older emergency department users: results of the ER 2 experimental study

• Protocol of the Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research (CHARIOT): Prospective Readiness cOhort (PRO) SubStudy

• Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX.

• Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

• Similarity network fusion (SNF) for the integration of multi-omics and microbiomes in respiratory disease
• Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma

• Remediation programmes for practising doctors to restore patient safety: the RESTORE realist review
• The visual vernacular: embracing photographs in research
• Author's reply. 2021. Journal of the Royal College of Physicians of Edinburgh.
• Putting spin on the great gamble

• OXTR moderates adverse childhood experiences on depressive symptoms among incarcerated males
• Savouring as an Intervention to Decrease Negative Affect in Anxious Mothers of Children with Autism and Neurotypical Children
• An fNIRS Investigation of Masculinity, Femininity, and Sex on Nonparents' Empathic Response to Infant Cries

• Novel Optineurin Frameshift Insertion in a Family With Frontotemporal Dementia and Parkinsonism Without Amyotrophic Lateral Sclerosis

• Nanotechnology Facilitated Cultured Neuronal Network and Its Applications

• "I decide myself"- A qualitative exploration of end of life decision making processes of patients and caregivers through Advance Care Planning

• Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia

• Genome wide study of tardive dyskinesia in schizophrenia.
• Large-scale evaluation of the Positive and Negative Syndrome Scale (PANSS) symptom architecture in schizophrenia

• Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging

• The trans-ancestral genomic architecture of glycemic traits
• Data resource profile: Understanding the patterns and determinants of health in South Asians-the South Asia Biobank

• Molecular Insights into the Flavivirus Replication Complex

• An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore.

• The Skin in Cowden Syndrome

• Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses

• Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration
• Investigation of the correlation between mildly deleterious mtDNA Variations and the clinical progression of multiple sclerosis.

• Virtual Clinical Encounter Examination (VICEE): A novel approach for assessing medical students' non-psychomotor clinical competency

• Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study
• Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

• Differential Household Attack Rates Mirror the Ability to Control Coronavirus Disease 2019 (COVID-19)

• A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

• Persistent Symptoms and Association With Inflammatory Cytokine Signatures in Recovered Coronavirus Disease 2019 Patients

• Author Correction: Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity

• Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum

• Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

• A flexible multiplexed immunosensor for point-of-care in situ wound monitoring

• The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity

• Virtual reality in medical students' education: a scoping review protocol

• Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019
• Perceived facilitators and barriers to chronic disease management in primary care networks of Singapore: a qualitative study

• Structures of wild-type and H451N mutant human lymphocyte potassium channel K V 1.3.

• Maintaining engagement with efficiency: Facilitating large-group online TBL

• Salt for Patients with Heart Failure and Hyponatremia?
• Sex Modifies the Association of Fibroblast Growth Factor 21 With Subclinical Carotid Atherosclerosis.

• The Moderating Role of Parental Sleep Knowledge on Children with Developmental Disabilities and Their Parents' Sleep
• The Recognition of Cross-Cultural Emotional Faces Is Affected by Intensity and Ethnicity in a Japanese Sample

• Trans-Ethnic Fine-Mapping of the Major Histocompatibility Complex Region Linked to Parkinson's Disease

• A 3D Fiber-Hydrogel Based Non-Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury

• Recalled Parental Bonding Interacts with Oxytocin Receptor Gene Polymorphism in Modulating Anxiety and Avoidance in Adult Relationships

• Targeted Lipidomics of Drosophila melanogaster During Development

• An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [ 11 C]PBR28 and [ 18 F]flumazenil PET Imaging

• Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus
• A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis.

• Baseline Neurodegeneration Influences the Longitudinal Effects of Tau on Cognition
• The Association Between Diabetes Mellitus and Mild Behavioral Impairment Among Mild Cognitive Impairment: Findings from Singapore

• Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis
• Defining negative symptoms remission in schizophrenia using the Brief Negative Symptom Scale

• Plasma Branched-Chain Amino Acids Are Associated With Greater Fasting and Postprandial Insulin Secretion in Non-diabetic Chinese Adults
• Diffusely increased 18 F-FDG thyroid radionuclide uptake is not always hyperthyroidism

• Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants

• 2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease.

• Management of individuals with germline variants in PALB2: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)
• Telomere biology disorders
• Homologous recombination deficiency: cancer predispositions and treatment implications
• Understanding patients' views and willingness toward the use of telehealth in a cancer genetics service in Asia. 2021. Journal of Genetic Counseling.

• Regional Diets Targeting Gut Microbial Dynamics to Support Prolonged Healthspan

• Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes

• The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects

• An Overview of Commercially Available Apps in the Initial Months of the COVID-19 Pandemic. 2021
• Vaccine acceptability, uptake and completion amongst men who have sex with men: A systematic review, meta-analysis and theoretical framework
• Correction to: Medical students' attitudes towards careers in primary care in Singapore

• Teledermatology in Primary Care in Singapore: Experiences of Family Doctors and Specialists

• Cutibacterium acnes: much ado about maybe nothing much.

• Mapping ethico-legal principles for the use of artificial intelligence in gastroenterology

• PPARs and Tumor Microenvironment: The Emerging Roles of the Metabolic Master Regulators in Tumor Stromal-Epithelial Crosstalk and Carcinogenesis

• Core-Shell Structured Antimicrobial Nanofiber Dressings Containing Herbal Extract and Antibiotics Combination for the Prevention of Biofilms and Promotion of Cutaneous Wound Healing

• Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2

• Epidemiology and Transmission Of Carbapenemase-Producing Enterobacteriaceae in a Healthcare Network of an Acute Hospital and Its Affiliated Intermediate- and Long-Term Care Facilities in Singapore

• Re: Chen et al.: The United States Eye Injury Registry: past and future directions (Ophthalmology. 2021;128:647-648)
• Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography
• Clinical and Multimodal Imaging Clues in Differentiating Between Tuberculomas and Sarcoid Choroidal Granulomas
• Conjunctival Findings in Patients With Coronavirus Disease 2019
• Zika Virus and Anterior Uveitis-4 Years After the Pandemic

• Changing the cortical conductor’s tempo: Neuromodulation of the claustrum

• Publisher Correction: Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

• Long-term effectiveness of mHealth physical activity interventions: a systematic review and meta-analysis of randomized-controlled trials

• Are digital technologies fit for clinical purposes? A systematic review and qualitative synthesis of information quality frameworks for digital healthcare

• Exercise testing in patients with aortic stenosis: clinically useful

• DNA-derived nanostructures selectively capture gram-positive bacteria

• Regulatory Light Chains in Cardiac Development and Disease
• Post COVID-19 Arterial Thromboembolism: A Clear and Present Danger

• Update in COVID-19
• Integrative microbiomics in bronchiectasis exacerbations

• Determinants of antibiotic over-prescribing for upper respiratory tract infections in an emergency department with good primary care access: a quantitative analysis

• Redefining scholarship for health professions education: AMEE Guide No. 142
• The curious case of case study research
• iViewExpert: A tool to uncover expertise and support surgical skills training
• Simulation for technical skill acquisition in open vascular surgery

• Monocyte progenitors give rise to multinucleated giant cells

• Amyloid Beta42 (Aβ42) Peptide Functionalized Iron Oxide Nanoparticles for Specific Targeting of SH-SY5Y Neuroblastoma Cells

• Food for Life and Palliation (FLiP)': a qualitative study for understanding and empowering dignity and identity for terminally ill patients in Asia

• A Cross-Sectional Study of the Clinical Metrics of Functional Status Tools in Pediatric Critical Illness
• Skeletal Muscle Changes, Function, and Health-Related Quality of Life in Survivors of Pediatric Critical Illness

• Higher extracellular water to total body water ratio was associated with chronic kidney disease progression in type 2 diabetes

• Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners
• Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes
• Author Correction: The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone
• Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study
• Predictors for development of critical illness amongst older adults with COVID-19: Beyond age to age-associated factors

• Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis

• Plasma neurofilament light chain levels predict improvement in late phase after stroke

• Mixed-charge pseudo-zwitterionic copolymer brush as broad spectrum antibiofilm coating

• Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

• The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

• Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells

• A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma

• Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation

• The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
• Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity
• Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

• Metabolomics Signatures of Aging: Recent Advances

• Personalised randomised controlled trial designs-a new paradigm to define optimal treatments for carbapenem-resistant infections

• Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore

George AUGUSTINE
Synapsins and the Synaptic Vesicle Reserve Pool: Floats or Anchors?.

Anna BARRON
Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy.
Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer's Disease.

Olivier BEAUCHET
Motoric cognitive risk syndrome: what's new?.
Pre-Dementia Stages and Incident Dementia in the NuAge Study.

David BECKER
Epidermal graft encourages wound healing by down-regulation of gap junctional protein and activation of wound bed without graft integration as opposed to split-thickness skin graft.
Pulpal upregulation of connexin 43 during pulpitis.
Characterisation of an ischemia reperfusion model for the formation of a stage I pressure ulcer in mouse skin.

David BECKER / TEY Hong Liang
Changes in connexin 43 in inflammatory skin disorders: Eczema, psoriasis, and Steven-Johnson syndrome/toxic epidermal necrolysis.

Per-Olof BERGGREN
Lowering apolipoprotein CIII protects against high-fat diet-induced metabolic derangements.

James BEST
School-based integrated healthcare model: how Our Mia Mia is improving health and education outcomes for children and young people.

Josip CAR
A Comparative Study of International and Asian Criteria for Overweight or Obesity at Workplaces in Singapore.

John CHAMBERS
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Low uptake of COVID-19 prevention behaviours and high socioeconomic impact of lockdown measures in South Asia: Evidence from a large-scale multi-country surveillance programme.

Angela CHOW
Healthcare workers as "canaries" for acute respiratory infections and pathogens during the COVID-19 pandemic.
The "Timeless" use of Influenza-like Illness Criteria for influenza Detection in the Tropics.
Epidemiological factors associated with recent HIV infection among newly-diagnosed cases in Singapore, 2013-2017.

Christine CHEUNG/ David LYE / Laurent RENIA
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation.

Sanjay CHOTIRMALL
Pseudomonas aeruginosa in bronchiectasis: infection, inflammation and therapies.
Respiratory Mycoses in COPD and Bronchiectasis.
Mycopathologia 2020: Legacy and Change to Remain Relevant for Content, Creation, and Communication.

Jennifer CLELAND
Optimising the delivery of remediation programmes for doctors: a realist review.
Performance at medical school selection correlates with success in Part A of the intercollegiate Membership of the Royal College of Surgeons (MRCS) examination.

Jennifer CLELAND / Lucy ROSBY
Cameras on or off: What is the question?.

Norris Ray DUNN
An NKX2-1 GFP and TP63 tdTomato dual fluorescent reporter for the investigation of human lung basal cell biology.

Gianluca ESPOSITO
An Analysis of the Generalizability and Stability of the Halo Effect During the COVID-19 Pandemic Outbreak.
A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior.
Deep Neural Networks and Transfer Learning on a Multivariate Physiological Signal Dataset.

FOO Jia Nee
Identification of a Novel Homozygous Missense (c.443A>T:p.N148I) Mutation in BBS2 in a Kashmiri Family with Bardet-Biedl Syndrome.

GUAN Xue Li
Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi.

Andy HO
Psychological resilience among palliative patients with advanced cancer: A systematic review of definitions and associated factors.

Andy HO / Olivier BEAUCHET
Long-term effects of the Montreal museum of fine arts participatory activities on frailty in older community dwellers: results of the A-Health study.

Balazs GULYAS
Auditory steady-state responses during and after a stimulus: Cortical sources, and the influence of attention and musicality.

HOU Han Wei
Direct and Label-Free Cell Status Monitoring of Spheroids and Microcarriers Using Microfluidic Impedance Cytometry.

Nagaendran KANDIAH
The Efficacy of Transdermal Rivastigmine in Mild to Moderate Alzheimer's Disease with Concomitant Small Vessel Cerebrovascular Disease: Findings from an Open-Label Study.

Jimmy LEE
Association Between Cardiovascular Risk Factors and Cognitive Impairment in People With Schizophrenia: A Systematic Review and Meta-analysis.
HOPES: An Integrative Digital Phenotyping Platform for Data Collection, Monitoring, and M.achine Learning
Predicting Real-World Functioning in Schizophrenia: The Relative Contributions of Neurocognition, Functional Capacity, and Negative Symptoms.

Melvin LEOW
Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults.
Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis.

LIM Kah Leong
Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.

Fabian LIM
Low muscle mass is associated with progression of chronic kidney disease and albuminuria - An 8-year longitudinal study in Asians with Type 2 Diabetes.

LUO Dahai
Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1.

David LYE
Risk Factors for Development of Acute Kidney Injury in COVID-19 Patients: A Retrospective Observational Cohort Study.
Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.

Joanne NGEOW
DNA methylation and breast cancer-associated variants.
CDKN2A germline alterations and the relevance of genotype-phenotype associations in cancer predisposition.
Clinical implementation of an oncology-specific family health history risk assessment tool.

Michael NILSSON
More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke.

Kevin PETHE
HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria.

Preman RAJALINGAM / Naomi LOW-BEER
Exploring the feasibility of using very short answer questions (VSAQs) in team-based learning (TBL).

Lucy ROSBY / Jerome ROTGANS / Naomi LOW-BEER
Promotion of knowledge transfer and retention in year 2 medical students using an online training exercise

Helen SMITH
A review of freely available online support for food allergy-related emotional wellbeing.
A retrospective cohort study examining secondary prevention post stroke in primary care in an Asian setting.
Characteristics of Patients Seeking and Proceeding with Non-Surgical Facial Aesthetic Procedures.

Joseph SUNG
Towards personalised management for non-variceal upper gastrointestinal bleeding.

Maurice van STEENSEL
Inherited skin disorders presenting with poikiloderma.

Andrew TAN
A 3D physio-mimetic interpenetrating network-based platform to decode the pro and anti-tumorigenic properties of cancer-associated fibroblasts.
GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

Navin VERMA
Prebiotics in atopic dermatitis prevention and management.

Franklin ZHONG
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.

Olivier BEAUCHET
SARS-CoV-2: To be or not to be vaccinated?.

Bernhard BOEHM
Consequences of the COVID-19 pandemic for patients with metabolic diseases.
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Josip CAR
The Missed Opportunity of Patient-Centered Medical Homes to Thrive in an Asian Context.

Christine CHEUNG
Blood Biomarkers To Detect New-Onset Atrial Fibrillation And Cardioembolism In Ischemic Stroke Patients.
Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines.

Bertrand CAZRNY
Extracellular Vesicle (EV) biohybrid systems for cancer therapy: Recent advances and future perspectives.

Rinkoo DALAN / Bernhard BOEHM
Non autoimmune type 1B diabetes after mild COVID-19: Report of three cases.
Diabetes Care During COVID-19 Pandemic in Singapore Using a Telehealth Strategy.

Norris Ray DUNN
An NKX2-1 GFP and TP63 tdTomato dual fluorescent reporter for the investigation of human lung basal cell biology.

Gianluca ESPOSITO
Bio-culturally grounded: why separation and connection may not be the same around the world.
Predictors of Contemporary under-5 Child Mortality in Low- and Middle-Income Countries: A Machine Learning Approach.

FOO Jia Nee
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.
High Diagnostic Utility Incorporating a Targeted Neurodegeneration Gene Panel With MRI Brain Diagnostic Algorithms in Patients With Young-Onset Cognitive Impairment With Leukodystrophy.

GUAN Xueli
Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy.

Andy HO
Building community resilience beyond COVID-19: The Singapore way.

Andy HO / PANG Weng Sun/ Josip CAR
Sustainable implementation of advance care planning in Asia: An interpretive-systemic framework for national development.

Suresh JESUTHASAN
Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection.

Jimmy LEE
Association between wrist wearable digital markers and clinical status in Schizophrenia.

Marie LOH / John CHAMBERS
DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures.

Marie LOH
Genome-wide identification of cis DNA methylation quantitative trait loci in three Southeast Asian Populations.

LUO Dahai
Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.

David LYE
Diagnostic performance of COVID-19 serological assays during early infection: A systematic review and meta-analysis of 11 516 samples.
Antimicrobial stewardship capacity and manpower needs in the Asia Pacific.
Effects of coronavirus disease 2019 (COVID-19) pandemic on antimicrobial prevalence and prescribing in a tertiary hospital in Singapore.
Human neutralising antibodies elicited by SARS-CoV-2 non-D614G variants offer cross-protection against the SARS-CoV-2 D614G variant.
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Safety of temporary interruption of antiplatelet therapy in dengue fever with thrombocytopenia.

Joanne NGEOW
Cost-effectiveness of olaparib maintenance therapy when used with and without restriction by BRCA1/2 mutation status for platinum-sensitive relapsed ovarian cancer.
Molecular connections between circadian rhythm and genome maintenance pathways.

Richard REYNOLDS
Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter.

Guy RUTTER
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.
Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function.

Yasunori SAHEKI
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.

Joseph SUNG
Challenges of developing artificial intelligence-assisted tools for clinical medicine.

Andrew TAN
Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy.
Mobilization efficiency is critically regulated by fat via marrow PPARδ.

TEOH Swee Hin
Biologization of Pcl-Mesh Using Platelet Rich Fibrin (Prf) Enhances Its Regenerative Potential In Vitro.

WANG Xiaomeng / Hendrik LUESCH
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.