Recent-Publications

Recent Publications

Feel free to read the most recent research publications from LKCMedicine's researchers below.
Rupesh AGRAWAL
Yusuf ALI
Olivier BEAUCHET
David BECKER
Lorainne Tudor CAR
Sanjay CHOTIRMALL
Jennifer CLELAND
Gianluca ESPOSITO
Michael FERENCZI
Jia Nee FOO
Konstadina GRIVA
Jimmy LEE
Dahai LUO
David LYE
David LYE / Barnaby Edward Young / Po Ying Chia
Oon Tek NG / Brenda S P Ang / Shawn Vasoo / Monica Chan /Yee Sin Leo
Joanne NGEOW
Sven PETTERSSON
Preman Rajalingam
Jerome ROTGANS
Laurent Rénia
Guy A RUTTER
Yasunori SAHEKI
Ern Yu TAN
Walter WAHLI
Yulan WANG
Tsin Wen YEO
Chee-Wah Tan, Wan-Ni Chia, Barnaby E Young, Feng Zhu, Beng-Lee Lim, Wan-Rong Sia, Tun-Linn Thein, Mark I-C Chen, Yee-Sin Leo, David C Lye, Lin-Fa Wang
Rupesh AGRAWAL
Christian J APFELBACHER
Yusuf ALI
Yusuf ALI / Chin Leong LIM / Su Chi LIM
Anna BARRON
Stefan R BORNSTEIN
Lorainne Tudor CAR
Lorainne Tudor CAR / Helen SMITH
Josip CAR
Josip CAR / Konstadina GRIVA
Josip CAR / Lorainne Tudor CAR
Angela CHOW / Hong Liang TEY
Angela CHOW / Yee Sin LEO
Jennifer CLELAND
Rinkoo DALAN
Gianluca ESPOSITO
Jia Nee FOO
Konstadina GRIVA
Han Wei HOU
Nagaendran KANDIAH
Jimmy LEE
Melvin LEOW
Kah Leong LIM
Dahai LUO
Joanne NGEOW
Joanne NGEOW / Helen SMITH
Sven PETTERSSON / Paul M MATTHEWS
Laurent Rénia
Helen SMITH
Joseph SUNG
Andrew TAN
Yulan WANG
Yulan WANG / Han Wei HOU
Eric Peng Huat YAP / Xueli GUAN
Christian J APFELBACHER
Christian J APFELBACHER / Helen SMITH
George AUGUSTINE
Olivier BEAUCHET
Josip CAR
Tom CARNEY
John CHAMBERS
Sanjay H CHOTIRMALL
Jennifer CLELAND
Gianluca ESPOSITO
Jia Nee FOO
Balazs GULYAS
Andy HO / Josip CAR
Nagaendran KANDIAH
Jimmy LEE
Kah Leong LIM
Marie LOH / John CHAMBERS
Dahai LUO
Oon Tek NG / Yee Sin LEO
Joanne NGEOW
Sven PETTERSSON
Richard Reynolds
Jerome I ROTGAN
Guy A RUTTER
Annelies Wilder SMITH
David LYE / Chia Yin Chong / Natalie Woon Hui Tan / Koh Cheng Thoon / Chee Fu Yung
David LYE / Barnaby Edward Young / Yee-Sin Leo
Tsin Wen YEO
George AUGUSTINE
Anna BARRON
David Laurence BECKER
Per-Olof BERGGREN
Lorainne Tudor CAR
Josip CAR
George CHANDY
Jennifer CLELAND
Rinkoo DALAN
Gianluca ESPOSITO
Jia Nee FOO
Jia Nee FOO / Sing Yian CHEW
Jia Nee FOO / Gianluca ESPOSITO
Xue Li GUAN
Balazs GULYAS
Han Wei HOU / Rinkoo DALAN
Nagaendran KANDIAH
Jimmy LEE
Melvin LEOW
Marie LOH
Dahai LUO
Joanne NGEOW
Sven PETTERSSON
Guy A RUTTER
Leopold SCHMETTERER
Helen SMITH
Helen SMITH / Maurice van STEENSEL
Maurice van STEENSEL
Joseph SUNG
Andrew TAN/ Walter WAHLI
Navin Kumar VERMA
David LYE / Barnaby Edward Young / Yee-Sin Leo
David LYE / Angela CHOW / Brenda ANG
Rupesh AGRAWAL
George AUGUSTINE
Olivier BEAUCHET
Lorainne Tudor CAR
Josip CAR
John CHAMBERS
Mary CHAN
Christine CHEUNG
Sanjay CHOTIRMALL
Angela CHOW
Jennifer CLELAND
GUAN Xue Li
Balazs GULYAS
Andy HO
Nagaendran KANDIAH
Melvin LEOW
Fabian LIM / Yusuf ALI
David LYE
Joanne NGEOW
Michael NILSSON
Kevin PETHE / Mary CHAN / NG Oon Tek
Richard REYNOLDS
Richard REYNOLDS / Sven PETTERSSON
Helen SMITH
Joseph SUNG
Andrew TAN
Walter WAHLI
WANG Yulan
YEO Tsin Wen
YEO Tsin Wen / David LYE

George AUGUSTINE
Synapsins and the Synaptic Vesicle Reserve Pool: Floats or Anchors?.

Anna BARRON
Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy.
Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer's Disease.

Olivier BEAUCHET
Motoric cognitive risk syndrome: what's new?.
Pre-Dementia Stages and Incident Dementia in the NuAge Study.

David BECKER
Epidermal graft encourages wound healing by down-regulation of gap junctional protein and activation of wound bed without graft integration as opposed to split-thickness skin graft.
Pulpal upregulation of connexin 43 during pulpitis.
Characterisation of an ischemia reperfusion model for the formation of a stage I pressure ulcer in mouse skin.

David BECKER / TEY Hong Liang
Changes in connexin 43 in inflammatory skin disorders: Eczema, psoriasis, and Steven-Johnson syndrome/toxic epidermal necrolysis.

Per-Olof BERGGREN
Lowering apolipoprotein CIII protects against high-fat diet-induced metabolic derangements.

James BEST
School-based integrated healthcare model: how Our Mia Mia is improving health and education outcomes for children and young people.

Josip CAR
A Comparative Study of International and Asian Criteria for Overweight or Obesity at Workplaces in Singapore.

John CHAMBERS
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Low uptake of COVID-19 prevention behaviours and high socioeconomic impact of lockdown measures in South Asia: Evidence from a large-scale multi-country surveillance programme.

Angela CHOW
Healthcare workers as "canaries" for acute respiratory infections and pathogens during the COVID-19 pandemic.
The "Timeless" use of Influenza-like Illness Criteria for influenza Detection in the Tropics.
Epidemiological factors associated with recent HIV infection among newly-diagnosed cases in Singapore, 2013-2017.

Christine CHEUNG/ David LYE / Laurent RENIA
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation.

Sanjay CHOTIRMALL
Pseudomonas aeruginosa in bronchiectasis: infection, inflammation and therapies.
Respiratory Mycoses in COPD and Bronchiectasis.
Mycopathologia 2020: Legacy and Change to Remain Relevant for Content, Creation, and Communication.

Jennifer CLELAND
Optimising the delivery of remediation programmes for doctors: a realist review.
Performance at medical school selection correlates with success in Part A of the intercollegiate Membership of the Royal College of Surgeons (MRCS) examination.

Jennifer CLELAND / Lucy ROSBY
Cameras on or off: What is the question?.

Norris Ray DUNN
An NKX2-1 GFP and TP63 tdTomato dual fluorescent reporter for the investigation of human lung basal cell biology.

Gianluca ESPOSITO
An Analysis of the Generalizability and Stability of the Halo Effect During the COVID-19 Pandemic Outbreak.
A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior.
Deep Neural Networks and Transfer Learning on a Multivariate Physiological Signal Dataset.

FOO Jia Nee
Identification of a Novel Homozygous Missense (c.443A>T:p.N148I) Mutation in BBS2 in a Kashmiri Family with Bardet-Biedl Syndrome.

GUAN Xue Li
Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi.

Andy HO
Psychological resilience among palliative patients with advanced cancer: A systematic review of definitions and associated factors.

Andy HO / Olivier BEAUCHET
Long-term effects of the Montreal museum of fine arts participatory activities on frailty in older community dwellers: results of the A-Health study.

Balazs GULYAS
Auditory steady-state responses during and after a stimulus: Cortical sources, and the influence of attention and musicality.

HOU Han Wei
Direct and Label-Free Cell Status Monitoring of Spheroids and Microcarriers Using Microfluidic Impedance Cytometry.

Nagaendran KANDIAH
The Efficacy of Transdermal Rivastigmine in Mild to Moderate Alzheimer's Disease with Concomitant Small Vessel Cerebrovascular Disease: Findings from an Open-Label Study.

Jimmy LEE
Association Between Cardiovascular Risk Factors and Cognitive Impairment in People With Schizophrenia: A Systematic Review and Meta-analysis.
HOPES: An Integrative Digital Phenotyping Platform for Data Collection, Monitoring, and M.achine Learning
Predicting Real-World Functioning in Schizophrenia: The Relative Contributions of Neurocognition, Functional Capacity, and Negative Symptoms.

Melvin LEOW
Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults.
Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis.

LIM Kah Leong
Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.

Fabian LIM
Low muscle mass is associated with progression of chronic kidney disease and albuminuria - An 8-year longitudinal study in Asians with Type 2 Diabetes.

LUO Dahai
Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1.

David LYE
Risk Factors for Development of Acute Kidney Injury in COVID-19 Patients: A Retrospective Observational Cohort Study.
Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.

Joanne NGEOW
DNA methylation and breast cancer-associated variants.
CDKN2A germline alterations and the relevance of genotype-phenotype associations in cancer predisposition.
Clinical implementation of an oncology-specific family health history risk assessment tool.

Michael NILSSON
More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke.

Kevin PETHE
HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria.

Preman RAJALINGAM / Naomi LOW-BEER
Exploring the feasibility of using very short answer questions (VSAQs) in team-based learning (TBL).

Lucy ROSBY / Jerome ROTGANS / Naomi LOW-BEER
Promotion of knowledge transfer and retention in year 2 medical students using an online training exercise

Helen SMITH
A review of freely available online support for food allergy-related emotional wellbeing.
A retrospective cohort study examining secondary prevention post stroke in primary care in an Asian setting.
Characteristics of Patients Seeking and Proceeding with Non-Surgical Facial Aesthetic Procedures.

Joseph SUNG
Towards personalised management for non-variceal upper gastrointestinal bleeding.

Maurice van STEENSEL
Inherited skin disorders presenting with poikiloderma.

Andrew TAN
A 3D physio-mimetic interpenetrating network-based platform to decode the pro and anti-tumorigenic properties of cancer-associated fibroblasts.
GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.

Navin VERMA
Prebiotics in atopic dermatitis prevention and management.

Franklin ZHONG
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.

 

Olivier BEAUCHET
SARS-CoV-2: To be or not to be vaccinated?.

Bernhard BOEHM
Consequences of the COVID-19 pandemic for patients with metabolic diseases.
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Josip CAR
The Missed Opportunity of Patient-Centered Medical Homes to Thrive in an Asian Context.

Christine CHEUNG
Blood Biomarkers To Detect New-Onset Atrial Fibrillation And Cardioembolism In Ischemic Stroke Patients.
Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines.

Bertrand CAZRNY
Extracellular Vesicle (EV) biohybrid systems for cancer therapy: Recent advances and future perspectives.

Rinkoo DALAN / Bernhard BOEHM
Non autoimmune type 1B diabetes after mild COVID-19: Report of three cases.
Diabetes Care During COVID-19 Pandemic in Singapore Using a Telehealth Strategy.

Norris Ray DUNN
An NKX2-1 GFP and TP63 tdTomato dual fluorescent reporter for the investigation of human lung basal cell biology.

Gianluca ESPOSITO
Bio-culturally grounded: why separation and connection may not be the same around the world.
Predictors of Contemporary under-5 Child Mortality in Low- and Middle-Income Countries: A Machine Learning Approach.

FOO Jia Nee
Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.
High Diagnostic Utility Incorporating a Targeted Neurodegeneration Gene Panel With MRI Brain Diagnostic Algorithms in Patients With Young-Onset Cognitive Impairment With Leukodystrophy.

GUAN Xueli
Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy.

Andy HO
Building community resilience beyond COVID-19: The Singapore way.

Andy HO / PANG Weng Sun/ Josip CAR
Sustainable implementation of advance care planning in Asia: An interpretive-systemic framework for national development.

Suresh JESUTHASAN
Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection.

Jimmy LEE
Association between wrist wearable digital markers and clinical status in Schizophrenia.

Marie LOH / John CHAMBERS
DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures.

Marie LOH
Genome-wide identification of cis DNA methylation quantitative trait loci in three Southeast Asian Populations.

LUO Dahai
Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.

David LYE
Diagnostic performance of COVID-19 serological assays during early infection: A systematic review and meta-analysis of 11 516 samples.
Antimicrobial stewardship capacity and manpower needs in the Asia Pacific.
Effects of coronavirus disease 2019 (COVID-19) pandemic on antimicrobial prevalence and prescribing in a tertiary hospital in Singapore.
Human neutralising antibodies elicited by SARS-CoV-2 non-D614G variants offer cross-protection against the SARS-CoV-2 D614G variant.
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Safety of temporary interruption of antiplatelet therapy in dengue fever with thrombocytopenia.

Joanne NGEOW
Cost-effectiveness of olaparib maintenance therapy when used with and without restriction by BRCA1/2 mutation status for platinum-sensitive relapsed ovarian cancer.
Molecular connections between circadian rhythm and genome maintenance pathways.

Richard REYNOLDS
Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter.

Guy RUTTER
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.
Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function.

Yasunori SAHEKI
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b.

Joseph SUNG
Challenges of developing artificial intelligence-assisted tools for clinical medicine.

Andrew TAN
Gestational age-specific normative values and determinants of serum progesterone through the first trimester of pregnancy.
Mobilization efficiency is critically regulated by fat via marrow PPARδ.

TEOH Swee Hin
Biologization of Pcl-Mesh Using Platelet Rich Fibrin (Prf) Enhances Its Regenerative Potential In Vitro.

WANG Xiaomeng / Hendrik LUESCH
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.

Olivier BEAUCHET
CHEW Sing Yian
Balazs GULYAS / Christer HALLDIN
LIM Kah Leong
  • Loss of FEZI, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development
Kevin PETHE / Mary CHAN / NG Oon Tek
Yusuf ALI / Bernhard BOEHM
Josip CAR

Annabel CHEN
Angela CHOW

Jennifer CLELAND​

James BEST


George AUGUSTINE


Christian APFELBACHER


Olivier BEAUCHET


Stefan BORNSTEIN


Josip CAR


Josip CAR/ Lorainne TUDOR CAR


Josip CAR/ Konstadina GRIVA


Lorainne TUDOR CAR


Tom CARNEY/ Maurice VAN STEENSEL


John CHAMBERS


Angela CHOW


Angela Chow/ David LYE


Rinkoo DALAN


Gianluca ESPOSITO


FOO Jia Nee


Birgitta HENRIQUES-NORMARK / Staffan NORMARK


Jimmy LEE


Fabian LIM


LUO Dahai/ Bertrand CZARNY/ Sanjay CHOTIRMALL/ Staffan NORMARK/ Birgitta HENRIQUES-NORMARK


David LYE


Joanne NGEOW


Michael NILSSON


Kevin PETHE/ NG Oon Tek/ Mary CHAN


Frank RUHLI/ Elio RIBOLI


Guy RUTTER


Leopold SCHMETTERER


Helen SMITH


Walter WAHLI

 
XIA Yun

 

George AUGUSTINE


Christian APFELBACHER

Anna BARRON



Olivier BEAUCHET​ / Andy HO


David BECKER


Josip CAR


Josip CAR / Lorraine Tudor CAR


Lorraine Tudor CAR​


Tom CARNEY / Philip INGHAM


CHEW Sing Yian


Sanjay CHOTIRMALL​

 

Sanjay CHOTIRMALL​ / Birgitta HENRIQUES-NORMARK /Staffan NORMARK / Bertrand CZARNY / Dahai LUO


Angela CHOW


Jennifer CLELAND


​FOO Jia Nee / Gianluca ESPOSITO


Balazs GULYAS / Christer HALLDIN




Christine WONG
 

YEO Tsin Wen

 

George AUGUSTINE


Olivier BEAUCHET​


Bernhard BOEHM


Bernhard BOEHM


Josip CAR


Jennifer CLELAND


Sanjay CHOTIRMALL​


Angela CHOW





Fabian LIM


David LYE


Joanne NGEOW

Kevin PETHE


Andrew TAN

 
WANG Xiaomeng / HOU Han Wei

Guy RUTTER

Yusuf ALI / Sarah LANGLEY


George AUGUSTINE


Olivier BEAUCHET​


Stefan BORNSTEIN​


Lorainne Tudor CAR


Lorainne Tudor CAR / THENG Yin Leng 


Christine CHEUNG


Sanjay CHOTIRMALL​


CHEW Sing Yian


Angela CHOW


Konstadina GRIVA


Andy HO





Joanne NGEOW

 


Joanne NGEOW / Marie LOH 

Dean NIZETIC / CHEW Sing Yian 


NG Oon Teck


Guy RUTTER

Leopold SCHMETTERER​


Mythily SUBRAMANIAM​

Andrew TAN

Navin VERMA / Dermot KELLEHER