Published on 13 Oct 2025

Pushing Frontiers in Chiral Surface Engineering: Prof Prashant Kumar Awarded Prestigious S$3.1M Singapore NRF Fellowship

Prof Prashant Kumar, from NTU’s School of Materials Science and Engineering, has been awarded the Singapore NRF Fellowship grant of S$3.1 million to lead pioneering research in biomolecular detection. The fellowship, one of Singapore’s most competitive research honours, supports early-career scientists with the potential to establish world-class research programmes that address pressing global challenges.

From Curiosity to Breakthroughs

For Prof Prashant, the journey began with a moment of awe: looking through an electron microscope for the first time.

It felt like having a superpower. I could directly see how atoms
arrange themselves and where tiny asymmetries arise,” he recalls.

That fascination grew into a deep interest in chirality; the left- and right-handed asymmetries that shape how molecules interact with light, energy, and even living systems. His NRF Fellowship project, Chiral Surface Engineering: Advancing Biomolecular Detection Through Engineered Interfaces and Advanced Electron Microscopy, builds on this early spark.

Tackling a Healthcare Grand Challenge

The project aims to address one of the most significant scientific and societal challenges: the early and reliable detection of diseases. Many serious conditions, from viral infections to neurodegenerative disorders, are linked to the presence of specific biomolecules. Yet today’s diagnostic methods are often complex, infrastructure-heavy, and difficult to deploy in real-world settings.

Prof Prashant’s vision is to engineer surfaces that can selectively detect biomolecules, enabling diagnostic technologies that are faster, more accurate, and more accessible. Such innovations could help democratise healthcare by making point-of-care testing possible even in resource-limited environments.

Pushing Technical Frontiers

This ambitious programme will tackle challenges at the edge of materials science and biology:

  • Achieving nanoscale control over chirality at interfaces, opening new ways to study molecular interactions.
  • Designing chiral surfaces that are stable yet sensitive, able to function in complex environments like blood or tissue.
  • Developing advanced electron microscopy methods, allowing researchers to watch chiral interactions unfold at the nanoscale.

By addressing these frontiers, the team hopes to unlock fundamentally new insights into how biology and materials communicate at the molecular level.

Nurturing Talent

Beyond the science, the NRF Fellowship provides a rare opportunity to shape future talent. Prof Prashant’s lab  will be a space where students and early-career researchers can gain hands-on experience in synthesis, characterisation, and device integration.

I want them to cultivate curiosity and resilience,” he explains. “Research isn’t just about metrics, it’s about exploration, where failures can teach as much as successes.

The Fellowship sets the stage for researchers to contribute to a programme built from the ground up, bringing together fundamental science, advanced electron microscopy, and real-world healthcare applications. By working seamlessly across synthesis, characterisation, and device integration, they can develop both breadth and depth of expertise, while learning to think across disciplines, communicate effectively, and approach problem-solving with creativity.

Several PhD and Post-Doctoral positions are now open in Prof Prashant’s lab presenting a rare opportunity to work at the cutting edge of chemistry, materials science, and biomedical engineering, right here in Singapore. 


Looking Ahead

With the support of the NRF Fellowship, Prof. Kumar and his team’s exploration of chirality at surfaces demonstrates how materials science and engineering connects atomic-scale phenomena with real-world applications. This work not only advances our understanding of matter, but also contributes to practical solutions in healthcare and other sectors — underscoring the discipline’s enduring relevance in addressing complex challenges.

PhD opportunities: https://www.ntu.edu.sg/mse/admissions/postgraduates/prospective-students/doctor-of-philosophy-master-of-engineering/opportunities