Developmental Biology & Regenerative Medicine

Programme Director: Philip Ingham

Developmental Biology addresses two of the most fundamental questions in biology: how do pluripotent cells give rise to the highly specialised cell types found within the body of an organism? and how are these cells assembled into the intricate patterns and shapes characteristic of different organs? 

For decades, these questions have been explored using model laboratory animals, especially fruit flies, chicks, mice and more recently zebrafish. But over the last ten years, the advent of organoids – cell assemblies resembling miniature organs, generated in vitro from stem cells – has opened up the possibility of studying human developmental processes directly.

The ability to image and manipulate human organoids in vitro, combined with the unprecedented resolution of single cell transcriptomic/epigenomic analysis in identifying and plotting the trajectory of distinct cell types, is transforming our understanding of human biology and providing new approaches to the analysis and treatment of diseases.

Researchers at LKCM are working with a variety of organoids – including blood vessels, brain, gut, kidney, lung and pancreas - with the ultimate aim of reversing the effects of degenerative diseases. This is highly interdisciplinary research, combining expertise in stem cell manipulation, high resolution imaging, next generation sequencing and bioinformatics as well as in biomaterial fabrication and microfluidics. 

The research is supported by superb infrastructure, including the animal research facility, tissue culture and high-content microscopy facilities, at the Clinical Sciences Building (CSB), Novena Campus. 

In complementary research based at the Experimental Medicine Building (EMB), NTU campus, the exceptional regenerative capacity of the zebrafish is being explored with a focus on the central nervous system, skin and musculo-skeletal system. 

Primary Faculty

Philip INGHAM FRS
Philip INGHAM FRS
PI, Developmental Genetics
Yen CHOO
Yen CHOO
Associate Professor of Stem Cell Science and Regenerative Medicine
Joanne NGEOW
Joanne NGEOW
Associate Professor
Norris Ray DUNN
Norris Ray DUNN
Associate Professor of Regenerative Medicine
Tom CARNEY
Tom CARNEY
PI, Dermal-Epidermal Interface
Christine Cheung
Christine CHEUNG
PI, Molecular & vascular 
medicine
Foo Jia Nee
FOO Jia Nee
PI, Genetics & genomics of neurological diseases
​XIA Yun
XIA Yun 
PI, Stem cell lineage specification
& organ regeneration

Joint & Adjunct Faculty

  • Chew Sing Yian (NTU School of Chemical and Biomedical Engineering)
  • Teoh Swee Hin (NTU School of Chemical and Biomedical Engineering)