Asst. Prof. Loh, Jia Tong
Assistant Professor
Phone: (65) 6514 1033
Email: [email protected]
Although it is well-recognized that our immune system matures and evolves from infancy to adulthood as posited by the hygiene hypothesis, the underlying phenotypic and functional differences between the pediatric and adult immune system, and how they can be shaped by pathogenic triggers and dietary factors, remain poorly understood. As such, the objective of our lab is to uncover the unknowns of immunoregulation and immunopathogenesis during early life using preclinical mouse models. This could aid in the (1) the identification of novel and specific therapeutic targets in children, (2) identification of children who are at risk of developing severe complications associated with infectious diseases for early intervention, and (3) development of novel vaccine adjuvants capable of promoting a more robust and prolonged immunity in children to reduce the need for booster shots.
Research Areas
Immunology, Innate immunity, Infectious diseases, Early life immunology
PhD Student
Project Officer
PhD Student
PhD Student
PhD Student
- Loh JT, Teo JKH, Kannan S, Verma C, Andiappan A, Lim HH, Lam KP. Dok3-PP4c complex negatively regulates Card11 signaling in T cells and affects severity of atopic dermatitis. Sci Signal. 2023. (*Co-corresponding author) https://doi.org/10.1126/scisignal.adg5171
- Loh JT, Lam KP. Fungal infections: Immune defense, immunotherapies and vaccines. Adv Drug Deliv Rev. 2023. (*Co-corresponding author) https://doi.org/10.1016/j.addr.2023.114775
- Loh JT, Lee KG, Lee AP, Teo JKH, Lim HL, Kim SSY, Tan AHM, Lam KP. DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils. Cell Death Dis. 2021;12:1054. https://doi.org/10.1038/s41419-021-04357-5
- Loh JT, Xu S, Huo JX, Kim SS, Wang Y, Lam KP. Dok3–protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Invest. 2019;129:2717–2729. https://doi.org/10.1172/jci126341
- Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LY, La Win MK, Yau YH, Guo T, See PCE, Yamazaki S, Chin KC, Gingras A, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH. The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat Immunol. 2015;16:505–516. (*co-first author) https://doi.org/10.1038/ni.312