SBS Research Pillar Key Visual for Development, Disease and Target Discovery Mobile Version

Profile Photo of SBS Faculty Zhu Guanhua

Dr. Zhu, Guanhua

We develop computational biology approaches by integrating cutting-edge AI and data science to advance biological research and healthcare. Our research leverages genomics, epigenomics, transcriptomics, fragmentomics, and chromatinomics to develop non-invasive biomarkers and AI-powered solutions for disease detection, treatment response inference, and precision medicine.


Research Areas

AI-driven biomarker development, Cancer liquid biopsy, Bioinformatics, Computational multi-omics
  • Zhu G, Rahman CR, Getty V, Odinokov D, Baruah P, Carrié H, Lim AJ, Guo YA, Poh ZW, Sim NL, Abdelmoneim A, Cai Y, Lakshmanan LN, Ho D, Thangaraju S, Poon P, Lau YT, Gan A, Ng S, Koo S-L, Chong DQ, Tay B, Tan TJ, Yap YS, Chok AY, Ng MCH, Tan P, Tan D, Wong L, Wong PM, Tan IB, Skanderup AJ. A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths. Nature Biomedical Engineering. 2025; 9:307–319. https://doi.org/10.1038/s41551-025-01370-3  
  • Zhu G, Jiang P, Li X, Peng W, Choy LYL, Yu SCY, Zhou Q, Ma MJL, Kang G, Bai J, Qiao R, Deng CXS, Ding SC, Lam WKJ, Chan SL, Lau SL, Leung TY, Wong J, Chan KCA, Lo YMD. Methylation-associated nucleosomal patterns of cell-free DNA in cancer patients and pregnant women. Clinical Chemistry. 2024;70(11):1355-65. https://doi.org/10.1093/clinchem/hvae118 
  • Zhu G, Guo Y, Ho D, Poon P, Poh ZW, Wong PM, Gan A, Chang MM, Kleftogiannis D, Lau YT, Tay B, Lim WJ, Chua C, Tan T, Koo S, Chong D, Yap YS, Tan I, Ng S, Skanderup AJ. Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden. Nature Communications. 2021;12:2229. https://doi.org/10.1038/s41467-021-22463-y 
  • Zhu G, Pan A, Grüber G, Lu L. Conformational states of Zika virus non-structural protein 3 determined by molecular dynamics simulations with small-angle X-Ray scattering data. Progress in Biophysics and Molecular Biology. 2019;143:13-9. https://doi.org/10.1016/j.pbiomolbio.2018.09.005 
  • Liu W, Liu X, Zhu G, Lu L, Yang D. A Method for Determining Structure Ensemble of Large Disordered Protein: Application to a Mechanosensing Protein. Journal of the American Chemical Society. 2018;140(36):11276-85. https://doi.org/10.1021/jacs.8b04792