Assoc. Prof. Bhattacharyya, Surajit
We are engaged in cutting edge research in the field of structural and molecular biophysics. We are investigating:
1. molecular mechanisms of b2 integrins signaling in leukocyte cell adhesion and migration and to develop anti-cancer therapeutics,
2. host defense antimicrobial peptides platform to combat drug resistant bacteria and
3. de-novo designed functional synthetic heme protein mimics
Research Areas
Structural biology, NMR, Functional protein design, Integrins, Antimicrobial peptides
Neeru Arya
Research Fellow
Research Fellow
Swaleeha Jaan
PhD Student
PhD Student
- Chatterjee D, D'Souza A, Zhang Y, Bin W, Tan SM, Bhattacharjya S. Interaction analyses of 14-3-3ζ, Dok1, and phosphorylated integrin β cytoplasmic tails reveal a bi-molecular switch in integrin regulation. J Mol Biol. 2018;430(21):4419-4430. https://doi.org/10.1016/j.jmb.2018.09.008
- Sinha S, Zheng L, Mu Y, Ng WJ, Bhattacharjya S. Structure and interactions of a host defense antimicrobial peptide thanatin in lipopolysaccharide micelles reveal mechanism of bacterial cell agglutination. Sci Rep. 2017 Dec 19;7(1):17795. https://doi.org/10.1038/s41598-017-18102-6
- D'Souza A, Wu X, Yeow EKL, Bhattacharjya S. Designed heme-cage β-sheet miniproteins. Angew Chem Int Ed Engl. 2017;56(21):5904-5908. https://doi.org/10.1002/anie.201702472
- Domadia PN, Bhunia A, Ramamoorthy A, Bhattacharjya S. Structure, interactions, and antibacterial activities of MSI-594 derived mutant peptide MSI-594F5A in lipopolysaccharide micelles: role of the helical hairpin conformation in outer-membrane permeabilization. J Am Chem Soc. 2010;132(51):18417-18428. https://doi.org/10.1021/ja1083255
- Bhunia A, Mohanram H, Domadia PN, Torres J, Bhattacharjya S. Designed beta-boomerang antiendotoxic and antimicrobial peptides: structures and activities in lipopolysaccharide. J Biol Chem. 2009;284(33):21991-22004. https://doi.org/10.1074/jbc.M109.013573