Late Assoc. Prof. Su, I-Hsin
Late Associate Professor
In biological systems, key cellular processes such as growth, differentiation, and migration are predominantly regulated by post-translational modifications. Among these, protein methylation has emerged as a critical mechanism for modulating protein function. Previously, we proposed a cytoplasmic role for the histone lysine methyltransferase Ezh2 in the regulation of lymphocyte activation (Cell 2005, 121, 425–436). Our recent findings demonstrate that Ezh2-mediated methylation of talin1—a pivotal regulator of cell migration—impairs its interaction with F-actin, thereby facilitating adhesion turnover and enhancing cell migration (Nature Immunology 2015, 16: 505–516). The physiological relevance of cytosolic Ezh2 has been further supported by studies in leukocytes (iScience 2018, 10: 23–39; J Immunol 2018, 201: 3651–3661) and in the context of neoplastic transformation (Oncogene 2018, 37: 461–477). These findings suggest that Ezh2 and other lysine methyltransferases may target a broader range of cytosolic proteins to regulate diverse signaling pathways.
Research Areas
Molecular Immunology, Cell Signaling
PhD Student
Research Fellow
PhD Student
PhD Student
PhD Student
Research Associate
MSc Student
- Fang, G., Wang, J., Xie, R., Zhang, L., Wang, X., Chen, X., Han, X., Zhang, T., Zheng, P., and Sun, H. “Single‑Cell Laser Emitting Cytometry for Label‑Free Nucleolus Fingerprinting.” Nature Communications 15 (2024): 7332. https://doi.org/10.1038/s41467-024-51574-5
- Lim, T.J.F., Bunjamin, M., Ruedl, C., and Su, I.H. “Talin1 Controls Dendritic Cell Activation by Regulating TLR Complex Assembly and Signaling.” Journal of Experimental Medicine 217 (2020): e20191810. https://doi.org/10.1084/jem.20191810
- Venkatesan, N., Deepa, P.R., Kannan, N., Lakshmi, S., Thirumalai, K., Devaraj, S.N., Devaraj, H., and Srinivas, B.H. “EZH2 Promotes Neoplastic Transformation Through VAV Interaction‑Dependent Extranuclear Mechanisms.” Oncogene 37 (2018): 461–477. https://doi.org/10.1038/onc.2017.309
- Gunawan, M., Venkatesan, N., Loh, J.T., Wong, J.F., Berger, H., Neo, W.H., Li, J., La Win, M.K., Yau, Y.H., Guo, T., Chew, S.H.S., Tan, J., Tong, J.S., Arumugam, T.V., Liou, Y.C., Wohland, T., Manser, E., Lim, L., Ruedl, C., and Su, I.H. “The Methyltransferase Ezh2 Controls Cell Adhesion and Migration Through Direct Methylation of the Extranuclear Regulatory Protein Talin.” Nature Immunology 16 (2015): 505–516. https://doi.org/10.1038/ni.3125
- Su, I., Basavaraj, A., Krutchinsky, A.N., Hobert, O., Ullrich, A., Chait, B.T., and Reinberg, D. “Polycomb Group Protein Ezh2 Controls Actin Polymerization and Cell Signaling.” Cell 121 (2005): 425–436. https://doi.org/10.1016/j.cell.2005.02.029