SBS Research Pillar Key Visual for Development, Disease and Target Discovery Mobile Version

Profile Photo of SBS Faculty Richard She

Asst. Prof. She, Richard

Nanyang Assistant Professor

Email: [email protected]
Personal Lab Webpage: http://richardshelab.com/

Elephants remember. Whales sing. Intelligence blossomed in a thousand specialized forms across the animal kingdom, with each species perfecting its own cognitive niche, hardwired for memory or navigation or song. But only humans possess the kind of cognition that builds civilizations and reaches for the stars. The secret lies in the human brain, which tripled in size over the past 7 million years. Our lab seeks to understand how and why this happened. As we stand at the dawn of machine intelligence, we look back into the past and ask: how did the original biological superintelligence on Earth evolve?

Research Areas

Stem cell biology, developmental neuroscience, CRISPR screening
Profile Photo of Lab Member Zhao Xueting
Zhao Xueting
PhD Student
  • She, R., Fair, T., Saunders, R.A., Pavlovic, B.J., Weissman, J.S., and Pollen, A.A. “Comparative Landscape of Genetic Dependencies in Human and Chimpanzee Stem Cells.” Cell 186, no. 14 (2023): 2977–2994. https://doi.org/10.1016/j.cell.2023.06.021
  • She, R., Luo, J., and Weissman, J.S. “Translational Fidelity Screens Reveal eIF3 as a Key Regulator of Start Codon Selectivity.” Nucleic Acids Research 51, no. 12 (2023): 6355–6369. https://doi.org/10.1093/nar/gkad421
  • Jakobson, C.M., She, R., and Jarosz, D.F. “Pervasive Function and Evidence for Selection Across Standing Genetic Variation in S. cerevisiae.” Nature Communications 10, no. 1 (2019): 1222. https://doi.org/10.1038/s41467-019-09273-2
  • She, R., and Jarosz, D.F. “Mapping Causal Variants with Single‑Nucleotide Resolution Reveals Biochemical Drivers of Phenotypic Change.” Cell 172, no. 3 (2018): 478–490.e15. https://doi.org/10.1016/j.cell.2017.12.015
  • She, R., Chakravarty, A.K., Layton, C.J., Chircus, L.M., Andreasson, J.O.L., Damaraju, N., McMahon, P.L., Buenrostro, J.D., Jarosz, D.F., and Greenleaf, W.J. “Comprehensive and Quantitative Mapping of RNA‑Protein Interactions Across a Transcribed Eukaryotic Genome.” Proceedings of the National Academy of Sciences of the United States of America 114, no. 14 (2017): 3619–3624. https://doi.org/10.1073/pnas.1616399114