Prof. Miao, Yansong
Professor (NRF Investigator)
Assistant Chair (Internationalization)
Email: yansongm@ntu.edu.sg
Personal Lab Webpage: https://blogs.ntu.edu.sg/miaolab/
Molecular Condensation for Cell Signaling in Space and Time:
The spatiotemporal regulation of cellular signaling through molecular condensation is an exciting and rapidly emerging field of research. While past studies have laid a solid foundation in understanding signaling transduction—uncovering key components and hierarchical networks—there remains a critical gap in knowledge about how functional assemblies with specific material properties control biochemical reactions during signaling processes. At our laboratory, we tackle these challenges by integrating interdisciplinary approaches to study condensation-mediated cytoskeleton remodeling and signal transduction across several biological systems in fungi and plants.
Research Areas
Biomolecular condensation, plant-microbe interaction, actin cytoskeleton, fungal polarity, plant immunity
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- Ma, Z., Xie, Y., Zhu, X., Chng, C.-P., Liang, Q., Huang, C., and Miao, Y. “Synthetic FLS2 Receptor Oligomer Boosts Plant Innate Immunity.” Science Advances (2026): in press
- Zhu, X., Wang, W., Sun, S., Chng, C.-P., Zhu, K., Xie, Y., He, D., Liang, Q., Wu, X., Gao, W., Miserez, A., Yu, J., Huang, C., Groves, J.T., and Miao, Y. “Bacterial XopR Subverts RIN4 Complex-Mediated Plant Immunity via Plasma Membrane-Associated Percolation.” Developmental Cell 60, no. 15 (2025): 2081–2096.e10. https://doi.org/10.1016/j.devcel.2025.03.002
- Zhu, K., Guo, X., Chandrasekaran, A., Miao, X., Rangamani, P., Zhao, W., and Miao, Y. “Membrane Curvature Initiates Cdc42-FBP17-N-WASP Clustering and Actin Nucleation.” The EMBO Journal 45, no. 3 (2026): 953–986. https://doi.org/10.1038/s44318-025-00677-w
- Ma, Q., Surya, W., He, D., Yang, H., Han, X., Nai, M.H., Lim, C.T., Torres, J., and Miao, Y. “Spa2 Remodels ADP-Actin via Molecular Condensation under Glucose Starvation.” Nature Communications 15 (2024): 4491. https://doi.org/10.1038/s41467-024-48863-4
- Liang, Q., Peng, N., Xie, Y., Kumar, N., Gao, W., and Miao, Y. “MolPhase, an Advanced Prediction Algorithm for Protein Phase Separation.” The EMBO Journal 43, no. 10 (2024): 1898–1918. https://doi.org/10.1038/s44318-024-00090-9