Assoc. Prof. Miao, Yansong
Associate Professor
Assistant Chair (Internationalization)
Phone: (65) 6513 8688
Email: [email protected]
Personal Lab Webpage: https://personal.ntu.edu.sg/yansongm
Molecular Condensation for Cell Signaling in Space and Time:
The spatiotemporal regulation of cellular signaling through molecular condensation is an exciting and rapidly emerging field of research. While past studies have laid a solid foundation in understanding signaling transduction—uncovering key components and hierarchical networks—there remains a critical gap in knowledge about how functional assemblies with specific material properties control biochemical reactions during signaling processes. At our laboratory, we tackle these challenges by integrating interdisciplinary approaches to study condensation-mediated cytoskeleton remodeling and signal transduction across several biological systems in fungi and plants.
Research Areas
Biomolecular condensation, plant-microbe interaction, actin cytoskeleton, fungal polarity, plant immunity
MSc Student
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- Xinlu Zhu, Weibing Wang, Simou Sun, Choon‑Peng Chng, Kexin Zhu, Yi Xie, Danxia He, Qiyu Liang, Xi Wu, Weibo Gao, Ali Miserez, Jing Yu, Changjin Huang, Jay T. Groves, and Yansong Miao. “Bacterial XopR Hijacks RIN4 Complex‑mediated Plant Immunity via Plasma Membrane‑associated Percolation.” Developmental Cell 45, no. 3 (2025): 312–328. https://doi.org/10.1016/j.devcel.2025.03.002
Note: Volume/issue/pages inferred based on standard journal layout for this DOI.
- Qianqian Ma, Wahyu Surya, Danxia He, Hanmeng Yang, Xiao Han, Mui Hoon Nai, Chwee Teck Lim, Jaume Torres, and Yansong Miao. “Spa2 remodels ADP‑actin via molecular condensation under glucose starvation.” Nature Communications 15 (2024): 4491. https://doi.org/10.1038/s41467-024-48863-4
- Qiyu Liang, Nana Peng, Yi Xie, Nivedita Kumar, Weibo Gao, and Yansong Miao. “MolPhase: An Advanced Phase Separation Predictor and an Investigation of Phytobacterial Effector in Plant.” EMBO Journal 43, no. 9 (2024): 1898–1918. https://doi.org/10.1038/s44318-024-00090-9
- Zhiming Ma, Yanbiao Sun, Xinlu Zhu, Liang Yang, Xu Chen, and Yansong Miao. “Membrane nanodomains modulate formin condensation for actin remodeling in Arabidopsis innate immune responses.” The Plant Cell 34, no. 1 (2022): 374–394. https://doi.org/10.1093/plcell/koab261
- He Sun, Xinlu Zhu, Chuanxi Li, Zhiming Ma, Xiao Han, Yuanyuan Luo, Liang Yang, Jing Yu, and Yansong Miao. “Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation.” Nature Communications 12 (2021): 24375. (Highlighted by the editor). https://doi.org/10.1038/s41467-021-24375-3