Assoc. Prof. Lee, Yi-Chen
Associate Professor
Assistant Chair (Alumni/Outreach)
Phone: (65) 6513 8270
Email: [email protected]
1. Ultrasensitive Biomarker Detection for Critical Neurodegenerative Conditions at Point-of-Care: Point-of-care (POC) solutions are pivotal in the realms of personalized and precision medicine. Leveraging cutting-edge protein detection technology utilizing optical fibers, our focus lies in projects centered around the detection of trivial amount biomarkers associated with neurodegenerative conditions. The aim should be to screen the potential patients in early stages for medical intervention and management.
2. Digital Biomarkers and Data Analytics for Chronic Conditions: In the management of chronic diseases, the routine collection and analysis of physical biomarkers have been essential. However, with the advent of digital technologies, the capability to gather digital biomarkers, empowering patients further in their healthcare journey. The integration of both physical and digital biomarkers has emerged as the prevailing approach in chronic disease management. FemTech, which focuses on female health, presents significant market potential. The major research would focus on female unmet medical needs like menopause related syndromes.
Research Areas
- Kropshofer, H., Vogt, A.B., Thery, C., Armandola, E.A., Li, B.C., Moldenhauer, G., Amigorena, S., and Hämmerling, G.J. “A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.” EMBO Journal 17, no. 11 (1998): 2971–2981. https://doi.org/10.1093/emboj/17.11.2971 PMID: 9606180; PMCID: PMC1170637
- Himmelreich, R., Hilbert, H., Plagens, H., Pirkl, E., Li, B.C., and Herrmann, R. “Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae.” Nucleic Acids Research 24, no. 22 (1996): 4420–4449. https://doi.org/10.1093/nar/24.22.4420 PMID: 8948633; PMCID: PMC146264
- Günther, S., Li, B.C., Miska, S., Krüger, D.H., Meisel, H., and Will, H. “A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients.” Journal of Virology 69, no. 9 (1995): 5437–5444. https://doi.org/10.1128/JVI.69.9.5437-5444.1995 PMID: 7636989; PMCID: PMC189390
- Chang, S.F., Chang, S.H., Li, B.C., Will, H., and Netter, H.J. “Characterization of nonconventional hepatitis B viruses lacking the core promoter.” Virology 330, no. 2 (2004): 437–446. https://doi.org/10.1016/j.virol.2004.10.001 PMID: 15567437
- “Structural and functional complexity of hepatitis B virus variant genomes and virus populations.” In Proceedings of the IX Triennial International Symposium on Viral Hepatitis and Liver Disease, edited by M. Rizzetto.