Asst. Prof. Nolan, Laura
Assistant Professor
Phone: (65) 6513 7677
Email: [email protected]
Personal Lab Webpage: https://lauranolanlab.com
Dr Laura Nolan is an Assistant Professor in the School of Biological Sciences and a Principal Investigator in the Singapore Centre for Environmental Life Sciences Engineering (SCELSE). Her research group focuses on understanding how biofilms develop and how members of these communities interact with one another in a range of settings, including those relevant to the food chain and infections. Her lab uses a systems biology approach to obtain a detailed molecular mechanistic understanding of these processes. The aim is to then use this information to direct interventions that modulate the composition of biofilms to have the most beneficial outcome for the local environment or host.
Research Areas
Research Assistant
PhD Student
PhD Student
Research Fellow
- Mossop M, Ish-Horowicz J, Hughes D, Dobra R, Cunanan AG, Rosenthal M, Carr SB, Ramadan N, Nolan LM*, Davies JC*. Chronicity counts: The impact of Pseudomonas aeruginosa, Staphylococcus aureus, and co-infection in cystic fibrosis. Am J Respir Crit Care Med. 2024 Feb 29. (*Co-corresponding authors) https://doi.org/10.1164/rccm.202312-2326LE
- Nolan LM, Cain AK, Clamens T, Furniss RCD, Manoli E, Sainz-Polo MA, Dougan G, Albesa-Jové D, Parkhill J, Mavridou DAI, Filloux A. Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells. Nat Microbiol. 2021;6:1199–1210. https://doi.org/10.1038/s41564-021-00950-8
- Hynen AL, Lazenby JJ, Savva GM, McCaughey LC, Turnbull L, Nolan LM*, Whitchurch CB*. Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms. Microbiology. 2021;167(2):000990. (*Co-corresponding authors) https://doi.org/10.1099/mic.0.000990
- Nolan LM, Turnbull L, Katrib M, Osvath SR, Losa D, Lazenby JJ, Whitchurch CB. Pseudomonas aeruginosa is capable of natural transformation in biofilms. Microbiology. 2020;166(10):995-1003. https://doi.org/10.1099/mic.0.000956
- Nolan LM, Whitchurch CB, Barquist L, Katrib M, Boinett CJ, Mayho M, Goulding D, Charles IG, Filloux A, Parkhill J, Cain AK. A global genomic approach uncovers novel components for twitching motility-mediated biofilm expansion in Pseudomonas aeruginosa. Microb Genom. 2018;4(11):e000229. https://doi.org/10.1099/mgen.0.000229