Prof. Sabapathy, Kanaga
President’s Chair Professor
Professor and Chair, School of Biological Sciences
Phone: (65) 6316 2822
Email: [email protected]
Personal Lab Webpage: https://www.thesabapathylab.com/home
Dr. Sabapathy’s group investigates the molecular mechanisms underlying cancer development and therapeutic response, with a primary focus on the p53 and p73 tumor suppressor pathways. Their research is centered on:
(i) elucidating the mechanistic basis of cellular transformation and resistance to cancer therapies through the study of the p53/p73 pathway;
(ii) developing platform technologies to enable novel therapeutic strategies; and
(iii) generating mouse models that accurately represent various cancer types to better understand the carcinogenic process.
Research Areas
Cancer Research, Cell Biology, Genomics, Biochemistry, Genetics and Molecular Biology, Proteomics and Proteins
Cheng Min En
Research Assistant
Research Assistant
Chew Kai Ning
Research Assistant
Research Assistant
Christian Heiko Krueger
Research Assistant
Research Assistant
Darcy Tiernan
MSc Student
MSc Student
Derrick Chia
Research Fellow
Research Fellow
Goh Wei Xuan
PhD Student
PhD Student
Le-Ann Hwang
Senior Project Manager
Senior Project Manager
Li Dan
Senior Research Fellow
Senior Research Fellow
Nguyen Ngoc Minh Truc
PhD Student
PhD Student
Sashwini Chandra Kumar
Research Assistant
Research Assistant
Wang Chao
Senior Research Fellow
Senior Research Fellow
- Lozano, G., Prives, C., and Sabapathy, K. “Mutant p53 Gain of Function: Why Many See It, Why Some Do Not.” Cancer Discovery 15, no. 6 (2025): 1099–1104. https://doi.org/10.1158/2159-8290.CD-24-1638
- Sabapathy, K., and Lane, D.P. “Therapeutic Targeting of p53: All Mutants Are Equal, but Some Mutants Are More Equal than Others.” Nature Reviews Clinical Oncology 15, no. 1 (2018): 13–30. https://doi.org/10.1038/nrclinonc.2017.151
- Dulloo, I., Phang, B.H., Othman, R., Tan, S.Y., Vijayaraghavan, A., Goh, L.K., Martin-Lopez, M., Marques, M.M., Li, C.W., Wang, D.Y., Marin, M.C., Xian, W., McKeon, F., and Sabapathy, K. “Hypoxia-Inducible TAp73 Regulates the Angiogenic Transcriptome and Supports Tumorigenesis.” Nature Cell Biology 17, no. 4 (2015): 511–523. https://doi.org/10.1038/ncb3130
- Lee, M.K., Teoh, W.W., Phang, B.H., Tong, W.M., Wang, Z.Q., and Sabapathy, K. “Cell-Type, Dose and Mutation-Type Specificity Dictate Mutant p53 Functions In Vivo.” Cancer Cell 22, no. 6 (2012): 751–764. https://doi.org/10.1016/j.ccr.2012.10.022
- Vikhansyaka, F., Toh, W.H., Dulloo, I., Wu, Q., Boominathan, L., Ng, H.H., Vousden, K., and Sabapathy, K. “p73 Supports Cellular Growth through c-Jun-Dependent AP-1 Transactivation.” Nature Cell Biology 9 (2007): 698–705. https://doi.org/10.1038/ncb1598