Prof. Lescar, Julien
Professor
Director, NTU Institute of Structural Biology
Phone: (65) 6908 2208
Email: [email protected]
Personal Lab Webpage: http://lescargroup.com/
We use a combination of scientific techniques in Structural Biology and Biochemistry to help the discovery of new therapeutics targeting infectious diseases such as malaria and RNA viruses (flaviviruses, alphaviruses, coronaviruses, pneumoviruses). More recently we have turned our attention to the development and application of enzymatic bioconjugation to produce homogeneous Antibody drug conjugates for cancer therapy and tumor imaging.
Research Areas
Structural Biology, Structure-based drug discovery, Enzymatic methods for bioconjugation, Antibody-Drug conjugates as cancer therapeutics, Nanobody radionuclides for cancer imaging
Presidential Postdoctoral Fellow
Research Fellow
Research Assistant
Project Officer
Research Associate
Senior Research Fellow
Research Fellow
Project Officer
- Wirjanata G, Dziekan JM, Lin J, El Sahili A, Nur Zulkifli E, Boentoro J, Go KD, Yu H, Partridge A, Olsen D, Prabhu N, Sobota RM, Nordlund P, Lescar J, Bozdech Z. Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development. Cell Chem Biol. 2024;31(4):743–759.e8. https://doi.org/10.1016/j.chembiol.2024.03.002
- Chung Z, Lin J, Wirjanata G, Dziekan JM, El Sahili A, Preiser PR, Bozdech Z, Lescar J. Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848. J Biol Chem. 2024;300(1):105586. https://doi.org/10.1016/j.jbc.2023.105586
- Ku Z, Xie X, Lin J, Gao P, Wu B, El Sahili A, Su H, Liu Y, Ye X, Tan EY, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Zou J, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z. Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth. Nat Commun. 2022;13(1):5552. https://doi.org/10.1038/s41467-022-33284-y
- Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Huan J, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J. Structure of the human metapneumovirus polymerase phosphoprotein complex. Nature. 2020;577(7789):275–279. https://doi.org/10.1038/s41586-019-1759-1
- Hemu X, El Sahili A, Hu S, Wong K, Chen Y, Wong YH, Zhang X, Serra A, Goh BC, Darwis DA, Chen MW, Sze SK, Liu CF, Lescar J, Tam JP. Structural determinants for peptide-bond formation by asparaginyl ligases. Proc Natl Acad Sci U S A. 2019;116(24):11737–11746. https://doi.org/10.1073/pnas.1818568116