SBS Research Pillar Key Visual for Development, Disease and Target Discovery Mobile Version

Profile Photo of SBS Faculty Dong Xueming

Asst. Prof. Dong, Xueming

Assistant Professor

Phone: (65) 6592 1549
Email: [email protected]
Personal Lab Webpage: https://donglabntu.owlstown.net/

 

We are interested in developing and employing mass spectrometry (MS) based analytical methods to study protein interactions in biological processes. MS is a powerful technique that is widely utilized in both academia and industry. 

Currently, we are interested in the following areas:

1. Protein-ligand interaction structural dynamics and kinetics in emerging infectious disease via hydrogen-deuterium exchange MS and native MS. 
2. Clinical and CLIA proteomics

3. MS instrumentation

Undergraduate and graduate students interested in bioanalytical chemistry with a focus in MS are welcome to inquire. Our group also welcome both academic and industrial collaborations.

Research Areas

Mass Spectrometry, LC-MS, Proteomics, Instrumentation, CLIA

Profile Photo of Lab Member Deng Ying
Deng Ying
PhD Student
Profile Photo of Lab Member Pang Li Ching
Pang Li Ching
PhD Student
Profile Photo of Lab Member Zhu Shuang Shuang
Zhu Shuangshuang
PhD Student
  • Dong, Xueming, Heather B. Mayes, Kris Morreel, Rui Katahira, Yanding Li, John Ralph, Brenna A. Black, and Gregg T. Beckham. "Energy‐Resolved Mass Spectrometry as a Tool for Identification of Lignin Depolymerization Products." ChemSusChem 16, no. 1 (2023): e202201441. https://doi.org/10.1002/cssc.202201441
  • Sullivan, Kevin P., Allison Z. Werner, Kelsey J. Ramirez, Lucas D. Ellis, Jeremy R. Bussard, Brenna A. Black, David G. Brandner, et al. "Mixed plastics waste valorization through tandem chemical oxidation and biological funneling." Science 378, no. 6616 (2022): 207–211. https://doi.org/10.1126/science.abo4626
  • Dong, Xueming, Yuyang Zhang, Jacob Milton, Ravikiran Yerabolu, Leah Easterling, and Hilkka I. Kenttämaa. "Investigation of the relative abundances of single-core and multicore compounds in asphaltenes by using high-resolution in-source collision-activated dissociation and medium-energy collision-activated dissociation mass spectrometry with statistical considerations." Fuel 246 (2019): 126–132. https://doi.org/10.1016/j.fuel.2019.02.080
  • Fan, Xing, Xiao-Yun Zhang, Xueming Dong, Jun-Jie Liao, Yun-Peng Zhao, Xian-Yong Wei, Feng-Yun Ma, and Aisha Nulahong. "Structural insights of four thermal dissolution products of Dongming lignite by using in-source collision-activated dissociation mass spectrometry." Fuel 230 (2018): 78–82. https://doi.org/10.1016/j.fuel.2018.04.164
  • Qi, Yaning, Mary Lay Cheng Chuah, Xueming Dong, Kailing Xie, Zhen Luo, Kai Tang, and Zhao-Xun Liang. "Binding of cyclic diguanylate in the non-catalytic EAL domain of FimX induces a long-range conformational change." Journal of Biological Chemistry 286, no. 4 (2011): 2910–2917. https://doi.org/10.1074/jbc.M110.196220