Asst. Prof. Bussi, Claudio
Nanyang Assistant Professor
Phone: (65) 6592 3673
Email: [email protected]
Personal Lab Webpage: www.bussilab.com
Our lab investigates fundamental aspects of lysosome biology, focusing on their diverse functions and the mechanisms ensuring lysosomal integrity through repair pathways. We delve into the molecular interactions between lysosomes, other membrane-bound organelles, and biomolecular condensates. A central theme of our research is understanding the dynamics between stress granules and endomembrane systems, particularly how these interactions influence the progression of neurodegenerative diseases.
Research Areas
Cell biology, Innate immunity, Trafficking, Lysosomes, Biomolecular condensates
Anabel Chang Jia Wei
PhD Student
PhD Student
Estephani Da Silva
Project Officer
Project Officer
Haykal Azman
Project Officer
Project Officer
Liang Qijian
PhD Student
PhD Student
Ruhani Varma
PhD Student
PhD Student
Weiping Li
Research Fellow
Research Fellow
- Bussi C, Heunis T, Pellegrino E, et al. Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism. Nat Commun. 2022;13:7338. https://doi.org/10.1038/s41467-022-34632-8
- Bussi C, Mangiarotti A, Vanhille-Campos C, et al. Stress granules plug and stabilize damaged endolysosomal membranes. Nature. 2023;623:1062–1069. https://doi.org/10.1038/s41586-023-06726-w
- Bussi C, Gutierrez MG. One size does not fit all: Lysosomes exist in biochemically and functionally distinct states. PLoS Biol. 2024 Mar;22(3):e3002576. https://doi.org/10.1371/journal.pbio.3002576
- Bussi C, Lai R, Athanasiadi N, Gutierrez MG. Physiologic medium renders human iPSC-derived macrophages permissive for M. tuberculosis by rewiring organelle function and metabolism. mBio. 2024;15:e00353-24. https://doi.org/10.1128/mbio.00353-24
- Prashar A, Bussi C, Fearns A, et al. Lysosomes drive the piecemeal removal of mitochondrial inner membrane. Nature. 2024;632:1110–1117. https://doi.org/10.1038/s41586-024-07835-w