POPX 2 phosphatase is a serine/threonine phosphatase which has been implicated in cancer metastasis.
The levels of POPX 2 are positively correlated to cell motility and invasiveness of cancer cells.
The calcium calmodulin kinase II (CaMKII) and p 21 activated kinase (PAK) are the first reported substrates of POPX 2.
Till date, many other substrates and interacting proteins of POPX 2 have been reported. Knowing the identities and physiological roles of these binding partners will allow us to find out how POPX 2 regulate metastasis and other cellular functions.
In this seminar, I will discuss the different approaches our laboratory has adopted to discover new POPX 2 interacting proteins and how these proteins can contribute to the functions of POPX 2.