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Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization.

Nucleic Acids Res. 2023 Apr 24:gkad252. doi: 10.1093/nar/gkad252. Epub ahead of print. PMID: 37094040

Liang Z, Lin Q, Wang Q, Huang L, Liu H, Shi Z, Cui Z, Zhou X, Gao YG, Zhou J, Zhang LH, Deng Y.

Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response.

BMC Biol. 2023 Mar 29;21(1):62. doi: 10.1186/s12915-023-01565-7. PMID: 36978084; PMCID: PMC10052836.

Zhang Y, Chew BLA, Wang J, Yuan M, Yam JKH, Luo D, Yang L.

Structural basis for the inhibitory mechanism of auranofin and gold(I) analogues against Pseudomonas aeruginosa global virulence factor regulator Vfr.

Comput Struct Biotechnol J. 2023 Mar 13;21:2137-2146. doi: 10.1016/j.csbj.2023.03.013. PMID: 37007650; PMCID: PMC10060147.

van den Elsen K, Chew BLA, Ho JS, Luo D.

Flavivirus nonstructural proteins and replication complexes as antiviral drug targets.

Curr Opin Virol. 2023 Mar 2;59:101305. doi: 10.1016/j.coviro.2023.101305. Epub ahead of print. PMID: 36870091.

Hemu X, Chan NY, Liew HT, Hu S, Zhang X, Serra A, Lescar J, Liu CF, Tam JP.

Substrate-binding Glycine Residues are Major Determinants for Hydrolase and Ligase Activity of Plant Legumains.

New Phytol. 2023 Feb 26. doi: 10.1111/nph.18841. Epub ahead of print. PMID: 36843268

Chua N, Wong YH, El Sahili A, Liu CF, Lescar J.

On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation.

FEBS Open Bio. 2023 Feb 14. doi: 10.1002/2211-5463.13575. Epub ahead of print. PMID: 36788723

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A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome.

Front Cell Dev Biol. 2023 Jan 26;11:1113656. doi: 10.3389/fcell.2023.1113656. PMID: 36776558; PMCID: PMC9908615.


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Targeting the alphavirus virus replication process for antiviral development.

Antiviral Res. 2022 Dec 24:105494. doi: 10.1016/j.antiviral.2022.105494. Epub ahead of print. PMID: 36574906

Tan YB, Chmielewski D, Law MCY, Zhang K, He Y, Chen M, Jin J, Luo D.

Molecular architecture of the Chikungunya virus replication complex.   

Sci Adv. 2022 Dec 2;8(48:eadd2536. doi: 10.1126/sciadv.add2536. Epub 2022 Nov 30. PMID: 36449616.

Wong CF, Saw WG, Basak S, Sano M, Ueno H, Kerk HW, Litty D, Ragunathan P, Dick T, Müller V, Noji H, Grüber G.  

Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors. 

Antimicrob Agents Chemother. 2022 Nov 29:e0105622. doi: 10.1128/aac.01056-22. Epub ahead of print. PMID: 36445139.

Soman A, Korolev N, Nordenskiöld L. 

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Curr Opin Struct Biol. 2022 Nov 3;77:102492. doi: 10.1016/ Epub ahead of print. PMID: 36335846.

Ku Z, Xie X, Lin J, Gao P, Wu B, El Sahili A, Su H, Liu Y, Ye X, Tan EY, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Zou J, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z.

Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.   

Nat Commun. 2022 Sep 22;13(1):5552. doi: 10.1038/s41467-022-33284-y. PMID: 36138032; PMCID: PMC9499943. 

Soman A, Wong SY, Korolev N, Surya W, Lattmann S, Vogirala VK, Chen Q, Berezhnoy NV, van Noort J, Rhodes D, Nordenskiöld L. 

Columnar structure of human telomeric chromatin.   

Nature. 2022 Sep;609(7929):1048-1055. doi: 10.1038/s41586-022-05236-5. Epub 2022 Sep 14. PMID: 36104563.

La Torre M, Merigliano C, Maccaroni K, Chojnowski A, Goh WI, Giubettini M, Vernì F, Capanni C, Rhodes D, Wright G, Burke B, Soddu S, Burla R, Saggio I.  

Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.   

J Exp Clin Cancer Res. 2022 Sep 13;41(1):273. doi: 10.1186/s13046-022-02480-5. PMID: 36096808; PMCID: PMC9469526.

Hu S, El Sahili A, Kishore S, Wong YH, Hemu X, Goh BC, Sang Z, Wang Z, Tam JP, Liu CF, Lescar J.

Suctural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase. 

Plant Cell. 2022 Sep 13:koac281. doi: 10.1093/plcell/koac281. Epub ahead of print. PMID: 36099055.

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Tetrad-binding ligands do not bind specifically to left-handed G-quadruplexes.  

Chem Commun (Camb). 2022 Sep 16. doi: 10.1039/d2cc03374g. Epub ahead of print. PMID: 36112098. 

Qiao Z, Kong Q, Tee WT, Lim ARQ, Teo MX, Olieric V, Low PM, Yang Y, Qian G, Ma W, Gao YG.

Molecular basis of the key regulator WRINKLED1 in plant oil biosynthesis.  

Sci Adv. 2022 Aug 26;8(34):eabq1211. doi: 10.1126/sciadv.abq1211. Epub 2022 Aug 24. PMID: 36001661; PMCID: PMC9401623.

Zhang K, Law MCY, Nguyen TM, Tan YB, Wirawan M, Law YS, Jeong LS, Luo D.

Molecular basis of specific viral RNA recognition and 5'-end capping by the Chikungunya virus nsP1.   

Cell Rep. 2022 Jul 26;40(4):111133. doi: 10.1016/j.celrep.2022.111133. PMID: 35905713.

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Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a syndrome with liver cirrhosis. 

Nat Genet. 2022 Jul 21. doi: 10.1038/s41588-022-01120-0. Epub ahead of print. PMID: 35864190.

Ngo KH, Liew CW, Lattmann S, Winnerdy FR, Phan AT.

Crystal structures of an HIV-1 integrase aptamer: Formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex.  

Biochem Biophys Res Commun. 2022 Jul 12;613:153-158. doi: 10.1016/j.bbrc.2022.04.020. Epub 2022 Apr 10. PMID: 35561583.

Cheong EZK, Quek JP, Xin L, Li C, Chan JY, Liew CW, Mu Y, Zheng J, Luo D.

Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold.  

J Biol Chem. 2022 Jul 11:102250. doi: 10.1016/j.jbc.2022.102250. Epub ahead of print. PMID: 35835220; PMCID: PMC9271420.

Quek JP, Ser Z, Chew BLA, Li X, Wang L, Sobota RM, Luo D, Phoo WW.

Dynamic Interactions of Post Cleaved NS2B Cofactor and NS3 Protease Identified by Integrative Structural Approaches.    

Viruses. 2022 Jun 30;14(7):1440. doi: 10.3390/v14071440. PMID: 35891424; PMCID: PMC9323329.

Ong ST, Tyagi A, Chandy KG, Bhushan S.

Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels. 

Front Pharmacol. 2022 Jun 27;13:924289. doi: 10.3389/fphar.2022.924289. PMID: 35833027; PMCID: PMC9271579.

Bose K, Maity A, Ngo KH, Vandana JJ, Shneider NA, Phan AT.

Formation of RNA G-wires by G4C2 repeats associated with ALS and FTD.  

Biochem Biophys Res Commun. 2022 Jun 25;610:113-118. doi: 10.1016/j.bbrc.2022.03.162. Epub 2022 Apr 4. PMID: 35462091.

Morthorst SK, Nielsen C, Farinelli P, Anvarian Z, Rasmussen CBR, Serra-Marques A, Grigoriev I, Altelaar M, Fürstenberg N, Ludwig A, Akhmanova A, Christensen ST, Pedersen LB.

Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling

J Cell Sci. 2022 Jun 15;135(12):jcs259471. doi: 10.1242/jcs.259471. Epub 2022 Jun 24. PMID: 35673984.

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Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling

J Cell Sci. 2022 Jun 15;135(12):jcs259471. doi: 10.1242/jcs.259471. Epub 2022 Jun 24. PMID: 35673984.

Yu D, Song W, Tan EYJ, Liu L, Cao Y, Jirschitzka J, Li E, Logemann E, Xu C, Huang S, Jia A, Chang X, Han Z, Wu B, Schulze-Lefert P, Chai J.

TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.   

Cell. 2022 May 13:S0092-8674(22)00530-X. doi: 10.1016/j.cell.2022.04.032. Epub ahead of print. PMID: 35597242. 

Hübner B, von Otter E, Ahsan B, Wee ML, Henriksson S, Ludwig A, Sandin S.

Ultrastructure and nuclear architecture of telomeric chromatin revealed by correlative light and electron microscopy. 

Nucleic Acids Res. 2022 Apr 30:gkac309. doi: 10.1093/nar/gkac309. Epub ahead of print. PMID: 35489064.  

Huber S, Braun NJ, Schmacke LC, Quek JP, Murra R, Bender D, Hildt E, Luo D, Heine A, Steinmetzer T.

Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.  

J Med Chem. 2022 Apr 27. doi: 10.1021/acs.jmedchem.1c01860. Epub ahead of print. PMID: 35475620.

Peng B, Nguyen TM, Jayasinghe MK, Gao C, Pham TT, Vu LT, Yeo EYM, Yap G, Wang L, Goh BC, Tam WL, Luo D, Le MT.

Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy.   

J Extracell Vesicles. 2022 Apr;11(4):e12187. doi: 10.1002/jev2.12187. PMID: 35430766; PMCID: PMC9013404.

da Silva RAG, Tay WH, Ho FK, Tanoto FR, Chong KKL, Choo PY, Ludwig A, Kline KA.

Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells.   

PLoS Pathog. 2022 Apr 7;18(4):e1010434. doi: 10.1371/journal.ppat.1010434. PMID: 35390107; PMCID: PMC9017951. 

Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L.

Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.

Nat Struct Mol Biol. 2022 Mar;29(3):190-193. doi: 10.1038/s41594-022-00729-3. Epub 2022 Mar 10. PMID: 35273390; PMCID: PMC8930769. 

Tyagi A, Ahmed T, Jian S, Bajaj S, Ong ST, Goay SSM, Zhao Y, Vorobyov I, Tian C, Chandy KG, Bhushan S.  

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.  

Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2113536119. doi: 10.1073/pnas.2113536119. PMID: 35091471. 

Yan XF, Yang C, Wang M, Yong Y, Deng Y, Gao YG.  

Structural analyses of the AAA+ ATPase domain of the transcriptional regulator GtrR in the BDSF quorum-sensing system in Burkholderia cenocepacia

FEBS Lett. 2022 Jan;596(1):71-80. doi: 10.1002/1873-3468.14244. Epub 2021 Dec 7. PMID: 34837384.

Tan YB, Lello LS, Liu X, Law YS, Kang C, Lescar J, Zheng J, Merits A, Luo D.

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.

Nucleic Acids Res. 2022 Jan 25;50(2):1000-1016. doi: 10.1093/nar/gkab1302. PMID: 35037043; PMCID: PMC8789068.  

Mansouri F, Patiny L, Ortiz D, Menin L, Davey CA, Mohammadi F, Dyson PJ.

Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action.   

J Biol Inorg Chem. 2022 Jan 22. doi: 10.1007/s00775-022-01924-9. Epub ahead of print. PMID: 35064831.  

Gharbi-Ayachi A, El Sahili A, Lescar J.

Purification of Dengue and Zika Virus Non-structural Protein 5 for Crystallization and Screening of Antivirals.   

Methods Mol Biol. 2022;2409:47-61. doi: 10.1007/978-1-0716-1879-0_5.  

Qiao Z, Lampugnani ER, Yan XF, Khan GA, Saw WG, Hannah P, Qian F, Calabria J, Miao Y, Grüber G, Persson S, Gao YG.

Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis. 

Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2024015118. doi: 10.1073/pnas.2024015118.

Merigliano C, Burla R, La Torre M, Del Giudice S, Teo H, Liew CW, Chojnowski A, Goh WI, Olmos Y, Maccaroni K, Giubettini M, Chiolo I, Carlton JG, Raimondo D, Vernì F, Stewart CL, Rhodes D, Wright GD, Burke BE, Saggio I.

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.

PLoS Genet. 2021 Aug 27;17(8):e1009757. doi: 10.1371/journal.pgen.1009757. Epub ahead of print. PMID: 34449766.

Li K, Zheng J, Wirawan M, Trinh NM, Fedorova O, Griffin PR, Pyle AM, Luo D.

Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).

Nucleic Acids Res. 2021 Aug 17:gkab712. doi: 10.1093/nar/gkab712. Epub ahead of print. PMID: 34403472.

Malleret B, El Sahili A, Tay MZ, Carissimo G, Ong ASM, Novera W, Lin J, Suwanarusk R, Kosaisavee V, Chu TTT, Sinha A, Howland SW, Fan Y, Gruszczyk J, Tham WH, Colin Y, Maurer-Stroh S, Snounou G, Ng LFP, Chan JKY, Chacko AM, Lescar J, Chandramohanadas R, Nosten F, Russell B, Rénia L.

Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells.

Nat Microbiol. 2021 Aug;6(8):991-999. doi: 10.1038/s41564-021-00939-3. Epub 2021 Jul 22. PMID: 34294905.

Chatain J, Blond A, Phan AT, Saintomé C, Alberti P.

GGGCTA repeats can fold into hairpins poorly unfolded by replication protein A: a possible origin of the length-dependent instability of GGGCTA variant repeats in human telomeres.

Nucleic Acids Res. 2021 Jul 2:gkab518. doi: 10.1093/nar/gkab518. Epub ahead of print. PMID: 34214172.

Chua EYD, Vasudevan D, Davey GE, Wu B, Davey CA.

Correction to article 'The mechanics behind DNA sequence-dependent properties of the nucleosome'.

Nucleic Acids Res. 2021 May 25:gkab464. doi: 10.1093/nar/gkab464. Epub ahead of print. Erratum for: Nucleic Acids Res. 2012 Jul;40(13):6338-52. PMID: 34037800.

Zhang K, Law YS, Law MCY, Tan YB, Wirawan M, Luo D.

Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1.

Cell Host Microbe. 2021 May 12; 29(5):757-764.e3. doi:10.1016/j.chom.2021.02.018

van den Elsen K, Quek JP, Luo D.

Molecular Insights into the Flavivirus Replication Complex.

Viruses. 2021 May 21;13(6):956. doi: 10.3390/v13060956. PMID: 34064113.

Ero R, Yan XF, Gao YG.

Ribosome Protection Proteins-"New" Players in the Global Arms Race with Antibiotic-Resistant Pathogens.

Int J Mol Sci. 2021 May 19;22(10):5356. doi: 10.3390/ijms22105356. PMID: 34069640; PMCID: PMC8161019.

Bu W, Levitskaya Z, Tan SM, Gao YG.

Emerging evidence for kindlin oligomerization and its role in regulating kindlin function.

J Cell Sci. 2021 Apr 15;134(8):jcs256115. doi: 10.1242/jcs.256115. Epub 2021 Apr 20. PMID: 33912917.

Zheng S, Matthews AJ, Rahman N, Herrick-Reynolds K, Sible E, Choi JE, Wishnie A, Ng YK, Rhodes D, Elledge SJ, Vuong BQ.

The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.

J Biol Chem. 2021 Apr 5:100625. doi: 10.1016/j.jbc.2021.100625. Epub ahead of print. PMID: 33831416.

Huang M, Zhang X, Toh GA, Gong Q, Wang J, Han Z, Wu B, Zhong F, Chai J.

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.

Nature. 2021 Mar 17. doi: 10.1038/s41586-021-03320-w. Epub ahead of print. PMID: 33731929.

Adhireksan Z, Sharma D, Lee PL, Bao Q, Padavattan S, Shum WK, Davey GE, Davey CA.

Engineering nucleosomes for generating diverse chromatin assemblies.

Nucleic Acids Res. 2021 Feb 15:gkab070. doi: 10.1093/nar/gkab070. Epub ahead of print. PMID: 33590100.

Tran NV, Nguyen LTA, Lim KW, Phan AT.

Potent and Selective Knockdown of Tyrosine Kinase 2 by Antisense Oligonucleotides

Immunohorizons. 2021 Feb 4;5(2):70-80. doi: 10.4049/immunohorizons.2000108. PMID: 33542028.

Das P, Ngo KH, Winnerdy FR, Maity A, Bakalar B, Mechulam Y, Schmitt E, Phan AT.

Bulges in left-handed G-quadruplexes. 

Nucleic Acids Res. 2021 Jan 27:gkaa1259. doi: 10.1093/nar/gkaa1259.

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New insights into the organization and regulation of the apical polarity network in mammalian epithelial cells. 

FEBS J. 2021 Jan 14. doi: 10.1111/febs.15710.

Wang S, Vogirala VK, Soman A, Berezhnoy NV, Liu ZB, Wong ASW, Korolev N, Su CJ, Sandin S, Nordenskiöld L.

Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome.

Sci Rep. 2021 Jan 11;11(1):380. doi: 10.1038/s41598-020-79654-8. PMID: 33432055; PMCID: PMC7801413.

Gong Q, Robinson K, Xu C, Huynh PT, Chong KHC, Tan EYJ, Zhang J, Boo ZZ, Teo DET, Lay K, Zhang Y, Lim JSY, Goh WI, Wright G, Zhong FL, Reversade B, Wu B.

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8. 

Nat Commun. 2021 Jan 8;12(1):188. doi: 10.1038/s41467-020-20319-5.


Rajan S., Jang Y., Kim C.H., Kim W., Toh H.T., Jeon J., Song B., Serra A., Lescar J., Yoo J.Y., Beldar S., Ye H., Kang C., Liu X.W., Feitosa M., Kim Y., Hwang D., Goh G., Lim K.L., Park H.M., Lee C.H., Oh S.F., Petsko G.A., Yoon H.S., Kim K.S. 

PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. 

Nature Chemical Biology, 25 May 2020; doi: 10.1038/s41589-020-0553-6. 

Tan, D.J.Y., Das, P., Winnerdy, F.R., Lim, K.W. & Phan, A.T.

Guanine anchoring: a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules.

Chem Communications, 27 Apr 2020; doi: 10.1039/d0cc01778g

Chew, B.L.A., Tanoto, F.R. & Luo, D. 

LC-MS assay targeting the mycobacterial indirect aminoacylation pathway uncovers glutaminase activities of the non-discriminating aspartyl-synthetase. 

FEBS Letters, 12 Apr 2020; doi: 10.1002/1873-3468.13786

Soman, A., Liew, C.W., Teo, H.L., Berezhnoy. N.V., Olieric, V., Korolev, N., Rhdoes, D. &  Nordenskiold, L. 

The human telomeric nucleosome displays distinct structural and dynamic properties. 

Nucleic Acid Research, 9 Apr 2020; doi: 10.1093/nar/gkaa289

Huoh, Y.S., Wu, B., Park, S., Yang, D., Bansal, K., Greenwald, E., Wong, W.P., Mathis, D. & Hur, S.

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance. 

Nature Communications, 2 Apr 2020; doi:

He, Q., Toh, J.D., Ero, R., Qiao, Z., Kumar, V., Serra, A., Tan, J., Sze, S.K. & Gao, Y.G.

The unusual di-domain structure of Dunaliella salina glycerol-3-phosphatedehydrogenase enables direct conversion of dihydroxyacetone phosphate toglycerol. 

The Plant Journal, Apr 2020; doi: 10.1111/tpj.14619. 

Traczyk, A., Liew, C.W., Gill, D.J. & Rhodes, D.

Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1. 

Nucleic Acids Research, 18 Mar 2020; doi:

Quek, J. P., Liu, S., Zhang, Z., Li, Y., Ng, E. Y., Loh, Y. R., Hung. A.W., Luo, D. & Kang, C. 

Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease. 

Antiviral Research, Mar 2020; doi:

Maity, A., Winnerdy, F.R., Chang, W.D., Chen, G. & Phan, A.T.

Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs.

Nucleic Acids Research, 26 Feb 2020; doi: 10.1093/nar/gkaa008

Ngo, K.H., Yang, R., Das, P., Nguyen, G.K.T., Lim, K.W., Tam, J.P., Wu, B. & Phan, A.T. 

Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity. 

Chem Communications, 2 Jan 2020; doi: 10.1039/c9cc06748e.

Phoo, W.W., El Sahili, A., Zhang, Z., Chen, M.W., Liew, C.W., Lescar, J., Vasudevan, S.G. & Luo, D.

Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3 upon binding to protease inhibitors. 

bioRxiv, 1 Jan 2020; doi:

Heymann, D., Mohanram, H., Kumar, A., Verma, C. S., Lescar, J., & Miserez, A. 

Structure of a consensus chitin-binding domain revealed by solution NMR. 

bioRxiv, 1 Jan 2020; doi:

Tsai, Y. C. C., Ye, F., Liew, L., Liu, D., Bhushan, S., Gao, Y. G., & Mueller-Cajar, O. 

Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase. 

Proceedings of the National Academy of Sciences, Jan 2020; doi: 10.1073/pnas.1911123117

Sharma, D., De Falco, L., Padavattan, S., Rao, C., Geifman-Shochat, S., Liu, C.F. & Davey, C.A. 

PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome.

Nature Communications, 17 Dec 2019; doi: 10.1038/s41467-019-13641-0.

Sharma D, De Falco L, Padavattan S, Rao C, Geifman-Shochat S, Liu CF, Davey CA. 

PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome.

Nat Commun. 2019 Dec 17;10(1):5751. doi: 10.1038/s41467-019-13641-0.

Jaroensuk J, Wong YH, Zhong W, Liew CW, Maenpuen S, Sahili AE, Atichartpongkul S, Chionh YH, Nah Q, Thongdee N, McBee ME, Prestwich EG, DeMott MS, Chaiyen P, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M.

Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa.

RNA. 2019 Nov;25(11):1481-1496. doi: 10.1261/rna.066746.118. 

Xie Y, Sun J, Han X, Turšić-Wunder A, Toh JDW, Hong W, Gao YG, Miao Y.

Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.

Nat Commun. 2019 Nov 7;10(1):5078. doi: 10.1038/s41467-019-13125-1.

Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Jia H, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J.

Structure of the human metapneumovirus polymerase phosphoprotein complex.

Nature. 2019 Nov 7. doi: 10.1038/s41586-019-1759-1. 

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Solution structures of a G-quadruplex bound to linear- and cyclic-dinucleotides.

J Am Chem Soc. 2019 Oct 29. doi: 10.1021/jacs.9b05642.

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Angew Chem Int Ed Engl. 2019 Oct 28;58(44):15660-15664. doi: 10.1002/anie.201906423.

Qiao Z, Sun H, Ng JTY, Ma Q, Koh SH, Mu Y, Miao Y, Gao YG.

Structural and computational examination of the Arabidopsis profilin-poly-P complex reveals mechanistic details in profilin-regulated actin assembly.

J Biol Chem. 2019 Oct 25. pii: jbc.RA119.011307. doi: 10.1074/jbc.RA119.011307. 

Li Y, Zhong W, Koay AZ, Ng HQ, Nah Q, Wong YH, Hill J, Lescar J, Dedon PC, Kang C.

Backbone resonance assignment for the full length tRNA-(N1G37) methyltransferase of Pseudomonas aeruginosa

Biomol NMR Assign. 2019 Oct;13(2):327-332. doi: 10.1007/s12104-019-09900-2

Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH.

Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.

Proc Natl Acad Sci U S A. 2019 Oct 11. pii: 201903695. doi: 10.1073/pnas.1903695116.

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NS5 from Dengue virus serotype 2 can adopt a conformation analogous to its ZIKV and JEV homologues.

J Virol. 2019 Oct 9. pii: JVI.01294-19. doi: 10.1128/JVI.01294-19.

Heddi B, Vee Cheong V, Schmitt E, Mechulam Y, Tuân Phan A.

Recognition of different base tetrads by RHAU: X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex.

J Struct Biol. 2019 Oct 3. pii: S1047-8477(19)30210-2. doi: 10.1016/j.jsb.2019.10.001.

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An unprecedented knot-like G-quadruplex peripheral motif.

Angew Chem Int Ed Engl. 2019 Sep 23;58(39):13834-13839. doi: 10.1002/anie.201907740. 

Zhong W, Pasunooti KK, Balamkundu S, Wong YH, Nah Q, Gadi V, Gnanakalai S, Chionh YH, McBee ME, Gopal P, Lim SH, Olivier N, Buurman ET, Dick T, Liu CF, Lescar J, Dedon PC.

Thienopyrimidinone derivatives that inhibit bacterial tRNA (Guanine37-N1)-methyltransferase (TrmD) by restructuring the active site with a tyrosine-flipping mechanism. 

J Med Chem. 2019 Sep 12;62(17):7788-7805. doi: 10.1021/acs.jmedchem.9b00582. 

Wang J, Alvin Chew BL, Lai Y, Dong H, Xu L, Balamkundu S, Cai WM, Cui L, Liu CF, Fu XY, Lin Z, Shi PY, Lu TK, Luo D, Jaffrey SR, Dedon PC.

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA.

Nucleic Acids Res. 2019 Sep 2. pii: gkz751. doi: 10.1093/nar/gkz751.

Gallart-Palau X, Tan LM, Serra A, Gao Y, Ho HH, Richards AM, Kandiah N, Chen CP, Kalaria RN, Sze SK.

Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. 

Ageing Res Rev. 2019 Aug;53:100909. doi: 10.1016/j.arr.2019.100909. 

Zhong W, Guo J, Cui L, Chionh YH, Li K, El Sahili A, Cai Q, Yuan M, Michels PAM, Fothergill-Gilmore LA, Walkinshaw MD, Mu Y, Lescar J, Dedon PC.

Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in Mycobacterium tuberculosis

J Mol Biol. 2019 Aug 2. pii: S0022-2836(19)30484-X. doi: 10.1016/j.jmb.2019.07.033. 

Kamariah N, Huber RG, Nartey W, Bhushan S, Bond PJ, Grüber G.

Structure and subunit arrangement of mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ. 

J Struct Biol. 2019 Aug 1;207(2):199-208. doi: 10.1016/j.jsb.2019.05.008. 

Yong HY, Zheng J, Ho VCY, Nguyen MT, Fink K, Griffin PR, Luo D.

Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I. 

FEBS Lett. 2019 Aug 1. doi: 10.1002/1873-3468.13564. 

Deng Y, Wu T, Wang M, Shi S, Yuan G, Li X, Chong H, Wu B, Zheng P.

Enzymatic biosynthesis and immobilization of polyprotein verified at the single-molecule level.

Nat Commun. 2019 Jun 24;10(1):2775. doi: 10.1038/s41467-019-10696-x.

Sun T, Mirzoev A, Minhas V, Korolev N, Lyubartsev AP, Nordenskiöld L.

A multiscale analysis of DNA phase separation: from atomistic to mesoscale level.

Nucleic Acids Res. 2019 Jun 20;47(11):5550-5562. doi: 10.1093/nar/gkz377.

Hemu X, El Sahili A, Hu S, Wong K, Chen Y, Wong YH, Zhang X, Serra A, Goh BC, Darwis DA, Chen MW, Sze SK, Liu CF, Lescar J, Tam JP.

Structural determinants for peptide-bond formation by asparaginyl ligases.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11737-11746. doi: 10.1073/pnas.1818568116. 

Dai L, Lin J, Said AB, Yau YH, Shochat SG, Ruiz-Carrillo D, Sun K, Chandrasekaran R, Sze SK, Lescar J, Cheung PC4.

Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage. 

Biochem Biophys Res Commun. 2019 Jun 4;513(3):714-720. doi: 10.1016/j.bbrc.2019.03.095. 

Bogdanović N, Trifunović D, Sielaff H, Westphal L, Bhushan S, Müller V, Grüber G.

The structural features of Acetobacterium woodii F-ATP synthase reveal the importance of the unique subunit γ-loop in Na+ translocation and ATP synthesis. 

FEBS J. 2019 May;286(10):1894-1907. doi: 10.1111/febs.14793.

Ahmed SM, Ramani PD, Wong SQR, Zhao X, Ivanyi-Nagy R, Leong TC, Chua C, Li Z, Hentze H, Tan IB, Yan J, DasGupta R, Dröge P.

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity. 

PLoS One. 2019 May 8;14(5):e0215696. doi: 10.1371/journal.pone.0215696. eCollection 2019.

Law YS, Utt A, Tan YB, Zheng J, Wang S, Chen MW, Griffin PR, Merits A, Luo D.

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase. 

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9558-9567. doi: 10.1073/pnas.1900656116. 

Ero R, Kumar V, Su W, Gao YG

Ribosome protection by ABC-F proteins-molecular mechanism and potential drug design. 

Protein Sci. 2019 Apr;28(4):684-693

Shimada M, Chen WY, Nakadai T, Onikubo T, Guermah M, Rhodes D, Roeder RG.

Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway. 

Mol Cell. 2019 Apr 18;74(2):268-283.e5. doi: 10.1016/j.molcel.2019.02.016. 

Li Y, Zhong W, Koay AZ, Ng HQ, Koh-Stenta X, Nah Q, Lim SH, Larsson A, Lescar J, Hill J, Dedon PC, Kang C.

Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase.

Biomol NMR Assign. 2019 Apr;13(1):49-53. doi: 10.1007/s12104-018-9849-9.

Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A.

A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex.

Cell Rep. 2019 Apr 9;27(2):387-399.e7. doi: 10.1016/j.celrep.2019.03.061.

Kesy J, Patil KM, Kumar SR, Shu Z, Yong HY, Zimmermann L, Ong AAL, Toh DK, Krishna MS, Yang L, Decout JL, Luo D, Prabakaran M, Chen G, Kierzek E. 

A short chemically modified dsRNA-binding PNA (dbPNA) inhibits influenza viral replication by targeting viral RNA panhandle structure. 

Bioconjug Chem. 2019 Mar 20;30(3):931-943. doi: 10.1021/acs.bioconjchem.9b00039. Epub 2019 Feb 15.

Del Rio D, Beucher B, Lavigne M, Wehbi A, Gonzalez Dopeso-Reyes I, Saggio I, Kremer EJ.

CAV-2 vector development and gene transfer in the central and peripheral nervous systems 

Front Mol Neurosci. 2019 Mar 29;12:71. doi: 10.3389/fnmol.2019.00071. eCollection 2019.

Zhong W, Koay A, Ngo A, Li Y, Nah Q, Wong YH, Chionh YH, Ng HQ, Koh-Stenta X, Poulsen A, Foo K, McBee M, Choong ML, El Sahili A, Kang C, Matter A, Lescar J, Hill J, Dedon P.

Targeting the bacterial epitranscriptome for antibiotic development: Discovery of novel tRNA-(N1G37) methyltransferase (TrmD) inhibitors. 

ACS Infect Dis. 2019 Mar 8;5(3):326-335. doi: 10.1021/acsinfecdis.8b00275. 

Rhodes D.

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Gu Y, Wong YH, Liew CW, Chan CEZ, Murali TM, Yap J, Too CT, Purushotorman K, Hamidinia M, El Sahili A, Goh ATH, Teo RZC, Wood KJ, Hanson BJ, Gascoigne NRJ, Lescar J, Vathsala A, MacAry PA.

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Nat Commun. 2019 Feb 21;10(1):893. doi: 10.1038/s41467-019-08790-1. 

Konarzewska P, Wang Y, Han GS, Goh KJ, Gao YG, Carman GM, Xue C.

Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans

J Biol Chem. 2019 Feb 15;294(7):2329-2339. doi: 10.1074/jbc.RA118.006738. 

Bakalar B, Heddi B, Schmitt E, Mechulam Y, Phan AT.

A minimal sequence for left-handed G-quadruplex formation. 

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2331-2335

Badolo A, Burt F, Daniel S, Fearns R, Gudo ES, Kielian M, Lescar J, Shi Y, von Brunn A, Weiss SR, Hilgenfeld R.

Third Tofo advanced study week on emerging and re-emerging viruses, 2018. 

Antiviral Res. 2019 Feb;162:142-150. doi: 10.1016/j.antiviral.2018.12.015.

Zheng S, Kusnadi A, Choi JE, Vuong BQ, Rhodes D, Chaudhuri J.

NME proteins regulate class switch recombination.

FEBS Lett. 2019 Jan;593(1):80-87. doi: 10.1002/1873-3468.13290. Epub 2018 Nov 23.

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The spatial separation of processing and transport functions to the interior and periphery of the Golgi stack.

Elife. 2018 Nov 30;7.

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The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis.

Elife. 2018 Oct 25;7. pii: e40037. doi: 10.7554/eLife.40037.

Peng M, Swarbrick CMD, Chan KW, Luo D, Zhang W, Lai X, Li G, Vasudevan SG.

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation.

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Phoo WW, Zhang Z, Wirawan M, Chen ECJ, Chew BL Alvin , Kouretova J, Steinmetzer T, Luo D.

Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.

Antiviral Res. 2018 Dec;160:17-24. doi: 10.1016/j.antiviral.2018.10.006.

Ha N, Lai LT, Chelliah R, Zhen Y, Yi Vanessa SP, Lai SK, Li HY, Ludwig A, Sandin S, Chen L, Zhang LF.

Live-Cell Imaging and Functional Dissection of Xist RNA Reveal Mechanisms of X Chromosome Inactivation and Reactivation.

iScience. 2018 Oct 26;8:1-14.

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A novel λ integrase-mediated seamless vector transgenesis platform for therapeutic protein expression.

Nucleic Acids Res. 2018 Sep 19;46(16):e99. doi: 10.1093/nar/gky500.

Merigliano C, Mascolo E, Burla R, Saggio I, Vernì F.

The Relationship Between Vitamin B6, Diabetes and Cancer.

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Sun H, Qiao Z, Chua KP, Tursic A, Liu X, Gao YG, Mu Y, Hou X, Miao Y.

Profilin Negatively Regulates Formin-Mediated Actin Assembly to Modulate PAMP-Triggered Plant Immunity.

Curr Biol. 2018 Jun 18;28(12):1882-1895.

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A systematic analysis of nucleosome core particle and nucleosome-nucleosome stacking structure.

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Supramolecular propensity of suckerin proteins is driven by β-sheets and aromatic interactions as revealed by solution NMR.

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Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome. 

Nucleic Acids Research, 2018, 46(22): 11659-11670. (NAR Breakthrough Article).

Shi X, Prasanna C, Nagashima T3, Yamazaki T, Pervushin K, Nordenskiöld L.

Structure and Dynamics in the Nucleosome Revealed by Solid-State NMR.

Angew Chem Int Ed Engl. 2018 Jun 14.

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Binding of a small molecule water channel inhibitor to aquaporin Z examined by solid-state MAS NMR.

J Biomol NMR. 2018 Jun;71(2):91-100.

Bogdanović N, Sundararaman L, Kamariah N, Tyagi A, Bhushan S, Ragunathan P, Shin J, Dick T, Grüber G.

Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε.

Journal of Structural Biology. 2018;204(3):420-34.

Gong Q, Long Z, Zhong FL, Teo DET, Jin Y, Yin Z, Boo ZZ, Zhang Y, Zhang J, Yang R, Bhushan S, Reversade B, Li Z, Wu B.

Structural basis of RIP2 activation and signaling.

Nature Communications. Nov 2018;9(1).

Su W, Kumar V, Ding Y, Ero R, Serra A, Lee BST, Wong ASW, Shi J, Sze SK, Yang L, Gao YG.

Ribosome protection by antibiotic resistance ATP-binding cassette protein.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):5157-5162.

Tharakaraman K, Watanabe S, Chan KR, Huan J, Subramanian V, Chionh YH, Raguram A, Quinlan D, McBee M, Ong EZ, Tan HC, Tyagi A, Bhushan S, Lescar J, Vasudevan SG, Ooi EE, Sasisekharan R .

Rational engineering and characterization of an mAb that neutralizes Zika virus by targeting a mutationally constrained quaternary epitope.

Cell Host Microbe 23(5):618-627.

Wong YH, Kumar A, Liew CW, Tharakaraman K, Srinivasaraghavan K, Sasisekharan R, Verma C, Lescar J.

Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513.

Sci Rep. 2018 May 31;8(1):8449.

Lescar J, Soh S, Lee LT, Vasudevan SG, Kang C, Lim SP.

The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity.

Adv Exp Med Biol. May 2018;1062:115-129.

Ruiz-Carrillo D, Lin J, El Sahili A, Wei M, Sze SK, Cheung PCF, Doerig C, Lescar J.

The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition.

Sci Rep. 2018 May 9;8(1):7365.

Sengar A, Vandana JJ, Chambers VS, Di Antonio M, Winnerdy FR, Balasubramanian S, Phan AT.

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.

Nucleic Acids Res. 2018 Dec 15.

Butovskaya E, Heddi B, Bakalar B, Richter SN, Phan AT.

Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop.

J Am Chem Soc. 2018 Oct 24;140(42):13654-13662.

Lim YT, Prabhu N, Dai L, Go KD, Chen D, Sreekumar L, Egeblad L, Eriksson S, Chen L, Veerappan S, Teo HL, Tan CSH, Lengqvist J, Larsson A, Sobota RM, Nordlund P.

An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions.

PLoS One. 2018 Dec 6;13(12):e0208273. doi: 10.1371/journal.pone.0208273. eCollection 2018.

Chatterjee D, D'Souza A, Zhang Y, Bin W, Tan SM, Bhattacharjya S.

Interaction Analyses of 14-3-3ζ, Dok1, and Phosphorylated Integrin β Cytoplasmic Tails Reveal a Bi-molecular Switch in Integrin Regulation.

J Mol Biol. 2018 Oct 19;430(21):4419-4430. doi: 10.1016/j.jmb.2018.09.008.

Mishra S, Ahmed T, Tyagi A, Shi J, Bhushan S.

Structures of Mycobacterium smegmatis 70S ribosomes in complex with HPF, tmRNA, and P-tRNA.

Sci Rep. 2018 Sep 11;8(1):13587. doi: 10.1038/s41598-018-31850-3.

Yong HY, Luo D.

RIG-I-Like Receptors as Novel Targets for Pan-Antivirals and Vaccine Adjuvants Against Emerging and Re-Emerging Viral Infections.

Front Immunol. 2018 Jun 20;9:1379. doi: 10.3389/fimmu.2018.01379. eCollection 2018. Review.

Chen S, Larsson M, Robinson RC, Chen SL.

Direct and convenient measurement of plasmid stability in lab and clinical isolates of E. coli.

Sci Rep. 2018 Apr 11;8(1):6056. doi: 10.1038/s41598-018-23595-w.

Li Y, Zhang Z, Phoo WW, Loh YR, Li R, Yang HY, Jansson AE, Hill J, Keller TH, Nacro K, Luo D, Kang C.

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Structure. 2018 Apr 3;26(4):555-564.e3. doi: 10.1016/j.str.2018.02.005. Epub 2018 Mar 8.

Bao Q, Morshedi A, Wang F, Bhargy S, Pervushin K, Yu WP, Dröge P.

Utf1 contributes to intergenerational epigenetic inheritance of pluripotency.

Sci Rep. 2018 Jan 23;8(1):1664. doi: 10.1038/s41598-018-20336-x.

Fong J, Zhang C, Yang R, Boo ZZ, Tan SK, Nielsen TE, Givskov M, Liu XW, Bin W, Su H, Yang L.

Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa.

Sci Rep. 2018 Jan 18;8(1):1155. doi: 10.1038/s41598-018-19504-w.

Pan A, Balakrishna AM, Nartey W, Kohlmeier A, Dip PV, Bhushan S, Grüber G.

Atomic structure and enzymatic insights into the vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit C.

Free Radic Biol Med. 2018 Feb 1;115:252-265. doi: 10.1016/j.freeradbiomed.2017.12.003. Epub 2017 Dec 6.

Yan XF, Xin L, Yen JT, Zeng Y, Jin S, Cheang QW, Fong RACY, Chiam KH, Liang ZX, Gao YG.

Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein.

J Biol Chem. 2018 Jan 5;293(1):100-111. doi: 10.1074/jbc.M117.815704. Epub 2017 Nov 16.

Liu C, Liew CW, Wong YH, Tan ST, Poh WH, Manimekalai MSS, Rajan S, Xin L, Liang ZX, Grüber G, Rice SA, Lescar J.

Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.

J Bacteriol. 2018 Jan 10;200(3). pii: e00515-17. doi: 10.1128/JB.00515-17. Print 2018 Feb 1.

Puah RY*, Jia H*, Maraswami M*, Toh DFK*, Ero R*, Yang L, Patil K, Ong AAL, Krishna M, Sun R, Tong C, Huang M, Chen X, Loh TP, Gao YG, Liu DX, Chen G.

Selective Binding to mRNA Duplex Regions by Chemically Modified PNAs Stimulates Ribosomal Frameshifting.

Biochemistry, Jan 2018, 57(1):149-159.

Swarbrick CMD, Basavannacharya C, Chan KWK, Chan SA, Singh D, Wei N, Phoo WW, Luo D, Lescar J, Vasudevan SG.

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

Nucleic Acids Res. 2017 Dec 15;45(22):12904-12920. 

Zhong W, Cui L, Goh BC, Cai Q, Ho P, Chionh YH, Yuan M, Sahili AE, Fothergill-Gilmore LA, Walkinshaw MD, Lescar J, Dedon PC. 

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.

Nat Commun. 2017 Dec 7;8(1):1986. 

Kang C, Keller TH, Luo D. 

Zika Virus Protease: An Antiviral Drug Target.

Trends Microbiol. 2017 Oct;25(10):797-808. 

Li Y, Zhang Z, Phoo WW, Loh YR, Wang W, Liu S, Chen MW, Hung AW, Keller TH, Luo D, Kang C.

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors. 

Structure.2017 Aug 1;25(8):1242-1250.

Li Y, Phoo WW, Loh YR, Zhang Z, Ng EY, Wang W, Keller TH, Luo D, Kang C.

Structural characterization of the linked NS2B-NS3 protease of Zika virus.

FEBS Lett. 2017 Aug;591(15):2338-2347

Chen MW, Tan YB, Zheng J, Zhao Y, Lim BT, Cornvik T, Lescar J, Ng LFP, Luo D.

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities.

Antiviral Res. 2017 Jul;143:38-47.

Wong YH, Goh BC, Lim SY, Teo EW, Lim APC, Dedon PC, Hanson BJ, MacAry PA, Lescar J.

Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex.

J Virol. 2017 Jun 21

El Sahili A, Lescar J.

Dengue Virus Non-Structural Protein 5.

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Engineering a Catalytically Efficient Recombinant Protein Ligase.

J Am Chem Soc. 2017 Apr 19;139(15):5351-5358.

Aw A, Gao X, Hao P, Gunalan K, Chu TT, Ameya S, Lescar J, Chandramohanadas R, Sze SK, Preiser PR.

RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC.

Cellular Microbiology 19(9) e12747 Apr 13

R.F.S. Lee, T. Riedel, S. Escrig, C. Maclachlan, G.W. Knott, C.A. Davey, K. Johnsson, A. Meibom & P.J. Dyson.

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study. 

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Ludwig, A., Nguyen, T.H., Leong, D., Ravi, L.I., Tan, B.H., Sandin, S. and Sugrue, R.J.

Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly.

Journal of cell science, 130, 1037-1050.

Davey, G.E., Adhireksan, Z., Ma, Z., Riedel, T., Sharma, D., Padavattan, S., Rhodes, D., Ludwig, A., Sandin, S., Murray, B.S. et al.

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation.

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Chua, E.Y.D. and Sandin, S.

Advances in phase plate cryo-EM imaging of DNA and nucleosomes.

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Belousoff MJ, Eyal Z, Radjainia M, Ahmed T, Bamert RS, Matzov D, Bashan A, Zimmerman E, Mishra S, Cameron D, Elmlund H, Peleg AY, Bhushan S, Lithgow T, Yonath A.

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.

MBio. 2017 May 9;8(3)

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Sci Rep. 2017 Jul 11;7(1):5159.

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A Dual-Specific Targeting Approach Based on the Simultaneous Recognition of Duplex and Quadruplex Motifs.

Sci Rep. 2017 Sep 20;7(1):11969.

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Rotation of Guanine Amino Groups in G-Quadruplexes: A Probe for Local Structure and Ligand Binding.

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Nucleic Acids Res. 2017 Jul 7;45(12):7487-7493.

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J Mol Biol. 2017 Jun 30;429(13):2075-2092

Peng, M., Watanabe, S., Chan, K. W. K., He, Q., Zhao, Y., Zhang, Z., Xiaoping, L., Dahai, L., Subhash, G. V., and Li, G. 

Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin. 

Antiviral Research, 5 Apr 2017; doi:


Adhireksan, Z., Palermo, G., Riedel, T., Ma, Z., Muhammad, R., Rothlisberger, U., Dyson, P. J. and Davey, C. A.

Allosteric cross-talk in chromatin can mediate drug-drug synergy.  

Nature Communications, 30 Mar 2017; doi:


Bi, X., Pasunooti, K. K., Lescar J. and Liu, C. F. 

Thiazolidine-masked α-oxo aldehyde functionality for peptide and protein modification.  

Bioconjugate Chemistry, 15 Feb 2017; doi:


Davies, R.B., Smits, C., Wong, A.S.W., Stock, D., Christie, M., Sandin, S. and Stewart, A.G. 

Cryo-EM analysis of a domain antibody bound rotary ATPase complex. 

Journal of structural biology, 20 Jan 2017; doi:


Sobti, M., Smits, C., Wong, A. S., Ishmukhametov, R., Stock, D., Sandin, S. and Stewart, A. G. 

Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states.  

Elife, 21 Dec 2016 ; doi:


Lim, S.K., Wong, A.S., de Hoog, H.M., Rangamani, P., Parikh, A.N., Nallani, M., Sandin, S. and Liedberg, B. 

Spontaneous formation of nanometer scale tubular vesicles in aqueous mixtures of lipid and block copolymer amphiphiles.  

Soft matter, 9 Dec 2016; doi:


Zhang, Z., Li, Y., Loh, Y. R., Phoo, W. W., Hung, A.W., Kang, C. and Luo, D. 

Crystal structure of unlinked NS2B-NS3 protease from Zika virus. 

Science, 8 Dec 2016; doi: 10.1126/science.aai9309


Jin, S., Sun, J., Wunder, T., Tang, D., Cousins, A. B., Sze, S. K., Mueller-Cajar, O. and Gao, Y.G. 

Structural insights into the LCIB protein family reveals a new group of β-carbonic anhydrases. 

Proceedings of the National Academy of Sciences,  1 Dec 2016; doi:


Ero, R., Kumar, V., Chen, Y. and Gao, Y.G.

Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to function. 

RNA Biology, 14 Nov 2016; doi:


Ahmed, T., Yin, Z., and Bhushan, S.

Cryo-EM structure of the large subunit of the spinach chloroplast ribosome. 

Scientific Reports, 20 Oct 2016; doi:


Chua, E.Y., Vogirala, V. K., Inian, O., Wong, A. S., Nordenskiöld, L., Plitzko, J. M., Danev, R. and Sandin, S.

3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM. 

Nucleic Acids Research, 30 Sep 2016; doi:


Jaroensuk, J., Atichartpongkul, S., Chionh, Y. H., Wong, Y. H., Liew, C. W., McBee, M. E., Thongdee, N., Prestwich, E. G., DeMott, M. S., Mongkolsuk, S., Dedon, P. C., Lescar, J. and Fuangthong, M. 

Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa. 

Nucleic Acids Research, 28 Sep 2016; doi:


Li, Y., Wong, Y. L., Lee, M. Y., Li, Q., Wang, Q. Y., Lescar, J., Shi, P. Y. and Kang C. 

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles.  

Angewandte Chemie, 24 Aug 2016; doi:


Sandin, S., Danev, R., Plitzko, J. M., Dao, E. C. Y., Vogirala, V. K., and Wong, A. S. W. 

High-resolution Imaging of Reconstituted Protein-DNA Complexes Using Phase Plate Electron Cryo Microscopy. 

Microscopy and Microanalysis, 25 July 2016; doi:


Ma, Z., Palermo, G., Adhireksan, Z., Murray, B.S., Von Erlach, T., Dyson, P.J., Rothlisberger, U. and Davey, C.A. 

An Organometallic Compound Which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode.  

Angewandte Chemie International Edition, 17 May 2016; doi:


Zou, S., Toh, J.D., Wong, K.H., Gao, Y.G., Hong, W. and Woon, E.C.

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5 

Scientific Reports, 9 May 2016; doi:


Kumar, V., Ero, R., Ahmed, T., Goh, K.J., Zhan, Y., Bhushan, S. and Gao, Y.G.

Structure of the GTP Form of Elongation Factor (EF4) Bound to the Ribosome. 

Journal of Biological Chemistry, 2 May 2016; doi: 10.1074/jbc.M116.725945


Hernández-Hernández, A., Masich, S., Fukuda, T., Kouznetsova, A., Sandin, S., Daneholt, B., and Höög, C. 

The central element of the synaptonemal complex in mice is organized as a bilayered junction structure.  

Journal of Cell Science, 14 Apr 2016; doi: 10.1242/jcs.182477


Vijaya, C. S. H., Makhija, H., Peter, S., Myint, W. C. M., Li, J., Zhu, J., Ren, Z.,  D'Alcontres, M. S., Siau, J. W., Chee, S., Ghadessy, F. J. and  Dröge, P. 

Conservative site-specific and single-copy transgenesis in human LINE-1 elements 

Nucleic Acids Research, 7 April 2016; doi:


Qian, X., Hamid, F.M., El Sahili, A., Darwis, D.A., Wong, Y.H., Bhushan, S., Makeyev, E.V. and Lescar, J.

Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases.

Journal of Biological Chemistry, 23 Feb 2016; doi: 10.1074/jbc.M115.685933


Wu, B., Huoh, Y. S., and Hur, S. 

Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors. 

Methods in Molecular Biology, 24 Jan 2016; doi:


Tay, M. Y., Smith, K., Ng, I. H., Chan, K. W., Zhao, Y., Ooi, E. E., Lescar, J., Luo, D., Jans, D.A., Forwood, J.K.  and Vasudevan, S. G.  

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. 

PLoS Pathogens 13 Sep 2016 Sep; doi: 10.1371/journal.ppat.1005886


Ludwig, A., Nichols, B.J. and Sandin, S.

Architecture of the caveolar coat complex. 

Journal of Cell Science, 15 Aug 2016; doi: 10.1242/jcs.191262


Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., El Sahili, A., Chan, G. K., Lescar, J., Arora, R., Benson, T., Nilar, S., Manjunatha, U., Wan, K. F., Dong, H., Xie, X., Shi, P. Y., and Yokokawa, F.  

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. 

PLoS pathogens, 12 Aug 2016; doi:


Palermo, G., Magistrato, A., Riedel, T., Von Erlach, T., Davey, C.A., Dyson, P.J. and Rothlisberger, U.

Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies.  

ChemMedChem, 4 Dec 2015; doi:

Chaston, J.J., Smits, C., Aragão, D., Wong, A.S., Ahsan, B., Sandin, S., Molugu, S.K., Molugu, S.K., Bernal, R.A., Stock, D. and Stewart, A.G.

Structural and Functional Insights into the Evolution and Stress Adaptation of Type II Chaperonins.

Structure, 16 Dec 2015; doi:


Qu, J., Ero, R., Feng, C., Ong, L.T., Tan, H.F., Lee, H.S., Ismail, M.H., Bu, W.T., Nama, S., Sampath, P. and Gao, Y.G.

Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells.

Scientific reports, 18 Dec 2015; doi:


Singh, D., Sielaff, H., Sundararaman, L., Bhushan, S. and Grüber, G.

The stimulating role of subunit F in ATPase activity inside the A1-complex of the Methanosarcina mazei Gö1 A1AO ATP synthase.

Biochimica et Biophysica Acta – Bioenergetics, 9 Dec 2015 ; doi:


Zhao, Y., Soh, T.S., Lim, S.P., Chung, K.Y., Swaminathan, K., Vasudevan, S.G., Shi, P.Y., Lescar, J. and Luo, D.

Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5). 

Proceedings of the National Academy of Sciences, 17 Nov 2015; doi:


Tsai, Y.C.C., Lapina, M.C., Bhushan, S. and Mueller-Cajar, O.

Identification and characterization of multiple rubisco activases in chemoautotrophic bacteria. 

Nature communications, 16 Nov 2015; doi:


Cheong, V.V., Lech, C.J., Heddi, B. and Phan, A.T.

Inverting the G-Tetrad Polarity of a G-Quadruplex by Using Xanthine and 8-Oxoguanine

Angewandte Chemie International Edition, 13 Nov 2015; doi:


Rhodes, D. and Lipps, H.J.

G-quadruplexes and their regulatory roles in biology.

Nucleic acids research, 10 Oct 2015; doi:


Li, Y., Kim, Y.M., Zou, J., Wang, Q.Y., Gayen, S., Wong, Y.L., Xie, X., Huang, Q., Lescar, J., Shi, P.Y. and Kang, C.

Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids. 

Biochimica et Biophysica Acta (BBA)-Biomembranes, 25 Sep 2015; doi:


Lee, R.F., Escrig, S., Croisier, M., Clerc-Rosset, S., Knott, G.W., Meibom, A., Davey, C.A., Johnsson, K. and Dyson, P.J.

NanoSIMS Analysis of an Isotopically Labelled Organometallic Ruthenium(II) Drug to Probe Its Distribution and State In Vitro.  

Chemical Communications, 23 Sep 2015; doi:


Cheong, V.V., Heddi, B., Lech, C.J. and Phan, A.T.

Xanthine and 8-oxoguanine in G-quadruplexes: formation of a G· G· X· O tetrad.

Nucleic acids research, 22 Sep 2015; doi:


Ye, F., Wang, C., Fu, Q., Zhang, L.H. and Gao, Y.G.

Cloning, expression, purification and crystallization of a pair of novel virulence factors, SghA and SghR, from Agrobacterium tumefaciens. 

Acta Crystallographica Section F: Structural Biology Communications, 25 Aug 2015; doi:


Kumar, V., Chen, Y., Ero, R., Ahmed, T., Tan, J., Li, Z., Wong, A.S.W., Bhushan, S. and Gao, Y.G.

Structure of BipA in GTP form bound to the ratcheted ribosome.

Proceedings of the National Academy of Sciences, 17 Aug 2015; doi:


Zhao, Y., Soh, T.S., Chan, K.W.K., Fung, S.S.Y., Swaminathan, K., Lim, S.P., Shi, P.Y., Huber, T., Lescar, J., Luo, D. and Vasudevan, S.G.

Flexibility of NS5 methyltransferase-polymerase linker region is essential for dengue virus replication.

Journal of virology, 12 Aug 2015; doi: 10.1128/JVI.01239-15


Wang, C., Yan, C., Gao, Y.G. and Zhang, L.H.

D101 is critical for the function of AttJ, a repressor of quorum quenching system in Agrobacterium tumefaciens.

Journal of Microbiology, 1 Aug 2015; doi:


Heddi, B., Cheong, V.V., Martadinata, H. and Phan, A.T.

Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex.

Proceedings of the National Academy of Sciences, 20 Jul 2015; doi:


Robinson, L.N., Tharakaraman, K., Rowley, K.J., Costa, V.V., Chan, K.R., Wong, Y.H., Ong, L.C., Tan, H.C., Koch, T., Cain, D., Kirloskar, R., Viswanathan, K., Liew, C.W., TIssire, H., Ramakrishnan, B., Myette, J.R., Babcock, G.J., Sasisekharan, V., Alonso, S., Chen, J., Lescar, J., Shriver, Z., Ooi, E.E. and Sasisekharan R.

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope.

Cell. 16 Jul 2015; doi:


Wu, B. and Hur, S.

How RIG-I like receptors activate MAVS.

Current opinion in virology, 13 May 2015; doi:


Lim, K.W., Jenjaroenpun, P., Low, Z.J., Khong, Z.J., Ng, Y.S., Kuznetsov, V.A. and Phan, A.T.

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study.

Nucleic acids research, 9 May 2015; doi:


Piazza, A., Adrian, M., Samazan, F., Heddi, B., Hamon, F., Serero, A., Lopes, J., Teulade‐Fichou, M.P., Phan, A.T. and Nicolas, A.

Short loop length and high thermal stability determine genomic instability induced by G‐quadruplex‐forming minisatellites.

The EMBO journal, 8 May 2015; doi:


Chua, E.Y., Davey, G.E., Chin, C.F., Dröge, P., Ang, W.H. and Davey, C.A.

Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents.

Nucleic acids research, 27 Apr 2015; doi:


Luo, D., Vasudevan, S.G. and Lescar, J.

The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development.

Antiviral research, 2 Apr 2015; doi:


Zhao, Y., Soh, T.S., Zheng, J., Chan, K.W., Phoo, W.W., Lee, C.C., Tay, M.Y., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.Y., Lescar, J., Vasudevan, S.G. and Luo, D.

A crystal structure of the Dengure virus NS5 protein reveals a novel inter-domain interface essential for protein flexbility and virus replication.

PLoS Pathogens, 16 Mar 2015; doi: 10.1371/journal.ppat.1004682


Ero, R., Dimitrova, V.T., Chen, Y., Bu, W., Feng, S., Liu, T., Wang, P., Xue, C., Tan, S.M. and Gao, Y.G.

Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans. 

Scientific Reports, 3 Mar 2015; doi:


Davey, C.A.

Exposure to metals can be therapeutic.

CHIMIA International Journal for Chemistry, 1  Mar 2015; doi:

Allahverdi, A., Chen, Q., Korolev, N. and Nordenskiöld, L.

Chromatin compaction under mixed salt conditions: opposite effects of sodium and potassium ions on nucleosome array folding.

Scientific reports, 17 Feb 2015; doi:


Lyubartsev, A.P., Korolev, N., Fan, Y. and Nordenskiöld, L.

Multiscale modelling of nucleosome core particle aggregation.

Journal of Physics: Condensed Matter, 7 Jan 2015; doi:


Zheng, J., Yong, H.Y., Panutdaporn, N., Liu, C., Tang, K. and Luo, D.

High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5.

Nucleic acids research, 24 Dec 2014; doi:


Tay, M.Y., Saw, W.G., Zhao, Y., Chan, K.W., Singh, D., Chong, Y., Forwood, J.K., Ooi, E.E., Grüber, G., Lescar, J., Luo, D. and Vasudevan, S.G.

The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication.

Journal of Biological Chemistry, 8 Dec 2014; doi: 10.1074/jbc.M114.607341


Toh, J.D., Sun, L., Lau, L.Z., Tan, J., Low, J.J., Tang, C.W., Cheong, E.J., Tan, M.J., Chen, Y., Hong, W. and Gao, Y.G.

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N 6-methyladenosine demethylase FTO. 

Chemical science, 22 Sep 2014; doi: 10.1039/C4SC02554G


Wang, C., Ye, F., Kumar, V., Gao, Y.G. and Zhang, L.H.

BswR controls bacterial motility and biofilm formation in Pseudomonas aeruginosa through modulation of the small RNA rsmZ. 

Nucleic acids research, 31 Jan 2014; doi: