Shaping Science at the Atomic Level: Exploring Structures, Inspiring Innovations.

NTU Institute of Structural Biology

Explore our facilities

A complete pipeline for structural biology

At NISB, we aim to integrate structural biology research across NTU to address fundamental questions in biology and human diseases. We have the expertise and equipment to bring your gene of interest from plasmid to structure.

Here is how we can aid you in your research:

 

  • Protein expression and purification: Protein purification is the core of structural biology. We offer a multitude of expression vectors and hosts to suit every possible protein. Optimizations will ensure maximum protein yield with the highest possible purity.
  • Biophysical characterization of proteins: Biophysical characteristics of proteins are an important to understanding the function of proteins. We provide instruments and the expertise to perform measurements to determine protein oligomeric states, ligand binding efficiency and size and distribution of your proteins.
  • Structural data collection and analysis: Structural data from proteins provide a wealth of knowledge. Using our in-house instruments, we can study protein structure using different approaches from NMR, X-ray crystallography to cryogenic electron microscopy. 

 

As a research center, we play a strategic role in the NTU Life / Biomedical Research Centre, which includes both LKC and SBS, as well as SCELSE, SPMS, and MSE.

 

Our scientific platforms

Explore our facilities

NISB is dedicated to deciphering the intricate 3D architecture of biomolecules, exploring their functions and interactions. With specialized platforms including Cryo-Electron Microscopy (CryoEM), Biophysics, and X-ray Crystallography, we delve into the fine details of the molecular world.

Our institute provides not only cutting-edge instrumentation but also holistic support. Our services extend from project planning and experimental design, to characterization and analysis, where our staff scientists ensure the accuracy and reliability of data. If required, our staff scientists can also aid in data analysis and interpretation to help you reach your research goals.

We also offer training for researchers, empowering them to operate instruments independently. Through hands-on workshops, seminars, and personalized guidance, we equip a new generation of researchers with skills in structural biology.

 

Research Focus

We have built on existing strengths and facilities to create a state-of-the-art technology platform encompassing all structural methods. Our work focuses on, but is not limited to, the following research fields:

 

Chromosomal Biology & Health

Synthetic Biology

Neurobiology

Infectious Diseases

Metabolic & Genetic Diseases

Drug Discovery & Design

Upcoming Events

View past events
Conferences & Seminars

2nd Singapore Structural Biology Symposium 2024

29 Feb 2024
Image depicting MicroED workflow in a seminar by Dr. Xu Hongyi
Workshops & Classes

MicroED workshop

17 Jul 2023
Workshops & Classes

Falcon 4i Selectris Workshop

27 Apr 2023 at 09.30 AM - 28 Apr 2023 at 03.45 PM
Conferences & Seminars

Singapore Structural Biology Symposium 2022

24 May 2022 - 25 May 2022

Our Insights

Prof Phan Anh Tuan and Dr Lim Kah Wai which led the groundbreaking study

Compound targets enzyme to reduce severity of autoimmune reactions

Prof Phan and his team designed a compound which could reduce the severity of autoimmune reactions, such as those linked to COVID-19 infections.

NTU team wins competitive S$2.8 million US grant for COVID-19 drug research

Led by NTU LKCMedicine’s Associate Professor of Infection and Immunity and Provost’s Chair in Medicine Luo Dahai, an expert in structural virology, the Singapore team will leverage NTU’s state-of-the-art molecular and structural biology research platform, NISB (NTU Institute of Structural Biology) to identify new antiviral drug targets.

Unravelling the mystery of human telomeric chromatin

A team of scientists led by Professor Lars Nordenskiöld, Chair of the School of Biological Sciences, has recently managed to shed some light on the molecular structure of telomeres. With help from NTU Institute of Structural Biology (NISB), the team made use of cryogenic electron microscopy to produce images of individual molecules. Their discovery has provided new insights into the maintenance and function of telomeres.