MAE Speaker Series Seminar on High-Content Biofabrication of Human Tissues

13 Nov 2025 10.00 AM - 11.00 AM LT5 (North Spine, NS2-02-07) Current Students, Public

A/P Y. Shrike Zhang

Department of Medicine, Harvard Medical School

Division of Engineering in Medicine, Brigham and Women’s Hospital

This seminar will be chaired by Prof Yeong Wai Yee.

Seminar Abstract

Over the last decades, the fabrication of three-dimensional (3D) tissues has become commonplace. However, conventional 3D fabrication techniques are limited in their capacity to produce complex tissue constructs with the required precision and controllability that is needed to replicate biologically relevant tissues. To this end, 3D bioprinting offers great versatility in the fabrication of biomimetic volumetric tissues that are structurally and functionally relevant. It enables precise control of the composition, spatial distribution, and architecture of bioprinted constructs facilitating the recapitulation of the delicate shapes and structures of target organs and tissues. This talk will discuss our recent efforts on developing various bioprinting methods that allow high-content biofabrication of human-relevant tissues to recapitulate the important biological and physiological parameters of their in vivo counterparts. These biomimetic tissues are anticipated to provide new opportunities in constructing functional tissues and their models for broad applications in regenerative medicine, drug discovery, therapeutics screening, and precision medicine.

 

Speaker's Biography 

Dr. Zhang is currently Associate Professor in the Department of Medicine at Harvard Medical School and Associate Bioengineer in the Division of Engineering in Medicine at the Brigham and Women’s Hospital. Dr. Zhang is directing the Laboratory of Engineered Living Systems (www.shrikezhang.com), where the research is focused on innovating medical engineering technologies, including 3D bioprinting, organs-on-chips, microfluidics, and bioanalysis, to recreate functional tissues and their biomimetic models, for applications in regenerative medicine and personalized medicine. He is an author of >360 peer-reviewed publications with citations ~48,000 and h-index=107). His scientific contributions have been recognized by >50 international, national, and regional awards.

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