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[SBS Seminar] Centromere-type transition in closely related human fungal pathogens
Centromeres are rapidly evolving across eukaryotes despite performing a conserved function to form the kinetochore and ensure high fidelity chromosome segregation In several fungal species, the centromere forms in a DNA sequence
dependent manner, whereas in other fungi, factors other than the DNA sequence, also determine the centromere
location.
In this talk, I will discuss our work on two closely related human fungal pathogens of CUG Ser 1 clade, Candida tropicalis and Candida albicans In this work, we constructed a chromosome level genome assembly of C tropicalis Based on comparative genome analysis and chromosome conformation capture sequencing data, we propose that spatial inter centromeric interactions facilitated karyotype evolution and rapid centromere type transition in the members of the CUG Ser 1 clade.