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[SBS Seminar] Regulation of protein degradation at stalled ribosomes
Faulty mRNAs arise in eukaryotic cells due to erroneous processing, genetic mutations or chemical modifications
These aberrant mRNAs can cause ribosomal stalling during translation, resulting in nascent protein degradation and
integrated stress response ( that represses global translation. I will discuss molecular events that follow
ribosomal stalling.
Importantly, compromised degradation of incomplete proteins at stalled ribosomes causes neuromuscular disorders in human I will present our work attempting to understand mechanisms underlying toxicity of stalled proteins.
We also discovered that Gcn 1 Gcn 20 complex, crucial in eliciting ISR, hampers degradation of stalled proteins I will discuss how the protein degradation pathway and the ISR signaling pathway are coordinated at stalled ribosomes.