RNA Folding and Therapeutics

 

Division of Chemistry and Biological Chemistry

School of Physical and Mathematical Sciences

Nanyang Technological University

 

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Welcome to Gang CHEN Research Group at NTU, Singapore

 

Our new group website: https://rna-chen.wixsite.com/mysite

 

 

Division of Chemistry and Biological Chemistry

School of Physical and Mathematical Sciences

Nanyang Technological University

Singapore 637371 

Singapore

 

Tel: +65 6592 2549 

Fax: +65 6791 1961

email: RNA-CHEN<at>outlook.com

Office: SPMS-CBC-05-22

Labs: SPMS-CBC-04-37 (wet lab),

SPMS-CBC-01-23-B (optical tweezers lab)

 

 

 

 

 

 

Dr Gang CHEN has been interested in probing the molecular recognition interactions responsible for RNA structures, stabilities, dynamics, and functions since 2001. He has worked on a variety of RNA structures including non-Watson-Crick base pairs (such as isoG-isoC, G-A, A-A, U-U, U-C, G-U, and A-C pairs), base triples, and pseudoknots. The triplex structures present in RNA pseudoknots inspired the current work on targeting RNA by dsRNA-binding chemically modified peptide nucleic acids (PNAs, see below), which show selective recognition of dsRNAs over ssRNAs and dsDNAs.

 

 

 

 

 

Dr. Gang CHEN received his B.S. degree in Chemistry at the University of Science and Technology of China (USTC) in 2001. He did his Ph.D. studies with Prof. Douglas TURNER in the Department of Chemistry at the University of Rochester. His Ph.D. work involved thermodynamic and NMR studies of RNA internal loops. A better understanding of the sequence dependence of thermodynamics for RNA structures will improve the accuracy of the RNA secondary structure prediction programs such as MFOLD and RNAstructure. He earned his Ph.D. in 2005. He was a postdoctoral fellow in Prof. Ignacio TINOCOs lab in the Department of Chemistry at the University of California, Berkeley from January 2006 to June 2009. His research in Tinoco lab was on single-molecule mechanical unfolding and folding of RNA pseudoknots by laser optical tweezers, which provided new insights into ribosomal reading-frame regulation by cis-acting mRNA structures. He was a Research Associate in Prof. David MILLAR's lab in the Department of Molecular Biology at The Scripps Research Institute working on HIV-1 Rev-RRE assembly using single-molecule fluorescence techniques. In July 2010, he joined the faculty in the Division of Chemistry and Biological Chemistry at Nanyang Technological University in Singapore.

 

Multiple positions (graduate students and postdoctoral fellows) are available in Dr. CHEN's group. Motivated students with high scientific ethics and strong research background are invited to join the multidisciplinary research group led by Dr. CHEN to probe and reprogram the structures, stabilities, dynamics, and biological functions of RNAs and RNA-protein complexes using various biological, physical, and chemical techniques. Interested undergraduate and graduate students are encouraged to contact Dr. CHEN by email (RNA-CHEN<at>outlook.com).

 

Our old lab website:  http://sites.google.com/site/rnachen2/