Assoc. Prof. Xing Bengang

Refereed Publications

After Joining NTU (Representtive Publications and Granted Patents):

Granted Patents:


1. "Quinazolinone Based Smart Fluorogenic Probes for Neurological Imaging." US Patent, 8,697,7114 B2, 2014 (Granted).

2. "Methods and Compounds for Screening Drug Resistant Bacterial Enzyme Functions", PAT/0421/07/08/US, 2014. (Granted)

Representive Publications:


62. Synthesis of Core-shell Lanthanide-Doped Upconversion Nanocrystals for Near-infrared Light-Mediated Bioapplications. X. Ai, L. Lyu, J. Mu, M. Hu, Z. Wang, B. G. Xing*. Journal of Visualized Experiment. (Video, Version), e56416, 2017. [PDF], [Link for Video].


61. Remote Regulation of Membrane Channel Activity by Site-specific Localization of lanthanide-doped Upconversion Nanocrystals. X. Ai, L. Lyu, Y. Zhang, Y. Tang, J. Mu, F. Liu, Y. Zhou, Z. Zuo, G. Liu,* B. G. Xing.* Angew. Chem. Intl. Ed2017, 56, 3031, Featured in "BackCover",and Highlighted in "Advanced Science News, Wiley";and"X-Mol";[PDF]; "[Cover]"


60. Enzyme-Repsonsive Reporter Molecules for Selective Localization and Fluorescent Imaging of Pathogenic Biolfilms. J. X. Aw, F. Widjiajia, Y. Ding, J. Mu, Y. Liang, and B. G. Xing*, Chem. Comm.,  2017, 53, 3330. Special Issue: Biological Optical Imaging, in Press, [PDF]

59. Investigation of Thermally Induced Cellular Ablation and Heat Response Triggered by Planar MoS2-based Nanocomposite. S. Ariyasu, J. Mu*, X. Zhang, Y. Huang, E. K. L. Yeow, H. Zhang*, B. G. Xing*. Bioconjugate Chem. 2017, 20, Accepted. [PDF]. 


58. Nanostrucutres for NIR Light-Controlled Therapies. Y. Y. Yang*, J. X. Aw, B. G. Xing*, Nanoscale. 2017, 53, (Invited Review), In press. [PDF].


57. Stimulus-Responsive Short Peptide Nanogels for Controlled Intracellular Drug Release and Overcome Tumor Resistance. L. Lvu, F. Liu, X. Wang, M. Hu, J. Mu, H. Cheong, G. Liu, B. G. Xing*, Chem. Asian. J. 2017, In press.[PDF], Featured as "Front Coverr"[PDF], "VIP Paper'" and "ChemistryViews".


56. Site-specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidocrylates. S. Ariyasu, H. Hayashi, B. G. Xing*, S. Chiba*. Bioconjugate Chem. 2017, 20, Accepted. [PDF], Featured as "ACS Editor's Choice".


55. Near Infared Light-mediated Photoactivation of Cytotoxic Re(I) Complex by Lanthanide-doped Upconversion Nanoparticles. M. Hu, J. Zhao, X. Ai, M. Budanovic, J. Mu, R. Webster, Q. Cao*, Z. Mao*., B. G. Xing*. Dalton Transactions, RSC, (Special Themed Issue on Metallodrugs: Activation, Targeting and Delivery), 2016, 45, 14101-14108. [PDF]


54. Light-mediated Theranosctics. X. Z. Ai, J. Mu, B. G. Xing*. Theranosctics. (Sepcial Issue in Light-Mediated Deep-tissue Theranostics), 2016, 6, 1899-1917. [PDF]

53. Photoactivated Drug Delivery and Bioimaging. Y. Yang*, J. Mu, B. G. Xing*. WIREs Nanomedicine & Nanobiotechnology. (Invited Review), 2016, In press. [PDF]  

52. Linking of Alcohols with Vinyl Azides. Y. Wang, M. Hu, H. Hayashi, B. G. Xing*., S. Chiba.* Org. Lett. , 2016, 18, 992. [PDF]   


51. Glycopeptide Antibiotic Analogs for Selective Inactivation and Two-Photon Imaging of Vancomycin-Resistant Strains. S. Ariyasu, P. Too, J. Mu, C. Goh, Y. Ding, Y. Tnay, E. Yeow, L. Yang, L. Ng, S. Chiba*, B. G. Xing*. Chem. Comm., 2016, 52, 4667. [PDF]   


50. In vivo Covalent Cross-linking of Photon-converted Rare-earth Nanostructures for Tumor Localization and Theranostics. X. Z. Ai, C. Ho, J. Aw, A. Attia, J. Mu, Y. Wang, X. Wang, Y. wang, X. Liu, H. Chen, M. Gao, X. Chen, E. K. Yeow, G. Liu*, M. Olivo,*, B. G. Xing*. Nature Communications, 2016, 7, 10432. [PDF]; Highlighted by "BioDiscover",[PDF]; "ScienceNet" [PDF]; and "X-MoL"; [PDF].


49. Human Transport Protein Carrier for Controlled Photoactivation of Antitumor Prodrug and Real-time Intracellular Tumor Imaging. X, Li, J. Mu, F. Liu, Eddy, Tan, B. Khezri, W. Richard, K. L. Yeow, B. G. Xing.* Bioconjugate Chem. 2015, 26, 955- 961. [PDF].  


48. Upconversion Nanoparticles for Bioimaging, X. Ai, J. Aw, B. G. Xing*. Phosphors, Upconversion Nanoparticles, Quantum Dots and their Applications.  Book chapter 28, Springer, 2015.


47. Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin. F. Liu*, J. Mu, B. G. Xing.* Curr. Pharm. Design2015,21, 1866-1888.[PDF]  Special Issue: Human Serum Albumin (HSA) based Drug Development and Drug Delivery.

46. Small Molecule FRET Reporter for the Real-time Visualization of Cell-Surface Proteolytic Enzyme Functions. J. Mu, F. liu*, M. Shafiq, M.Shi, L. Lu, Q. Xu, B. Liu, L. Ng, B. G. Xing*. Angew. Chem. Intl. Ed2014, 53, 14357-14362. [PDF] and [US patent application, 2014].

45. Allenamides as Orthogonal Handle for Selective Modification of Cysteine in Peptides and Proteins. A. Abbas, B. G. Xing*, T. P. Loh*. Angew. Chem. Intl. Ed2014, 53, 7491 [PDF], and [US patent application, filed, 2014].


44. Peptide-Perylene Diimide Functionalized Magnetic Nano-platforms for Fluorescence Turn-on Detection and Clearance of Bacterial Lipopolysaccharride. F. Liu, J. Mu, X. Wu, B. Surajit, B,* K.  l. Yeow*, B. G. Xing*.Chem Commun,2014, 50, 6200.[PDF] and Featured as "Inside cover"'.[US and SG patent application, Filed 2014]. 


43. Enzyme Responsive Cell-penetrating Peptides Mesoporous Silica Coated QDs Nanocarriers for Controlled Release of Nucleus Targeted Drug Molecules and Real-time Intracellular Fluorescent Imaging of Tumor Cells. J. Li, F. Liu, Q. Shao, Y. Min, K.  l. Yeow*, B. G. Xing*. Advanced Healthcare Materials, Special Issue: Drug Delivery Systems to Advanced Healthcare Materials. 2014, 3, 1230. [PDF] and Featured as "Front Cover"].


42. Recent Advance of Biological Molecular Imaging Based on Lanthanide-doped Upconversion-luminescent Nanomaterials. Y. Min, J. Li, F. Liu, K.  l. Yeow*, B. G. Xing*. Nanomaterials, Invited Review for Special Issue: Current Trends in Up-Converting Nanoparticles, 2014, 4, 129. [PDF]

41. NIR Light Mediated Photoactivation Pt Based Antitumor Prodrug and Simultanous Cellular Apoptosis Imaging Via Upconversion Nanoparticles. Y. Min, J. Li, F. Liu, K.  l. Yeow*, B. G. Xing*. Angew. Chem. Intl. Ed2014, 53, 1012. [PDF].


40. A Covalent Reporter of B-Lactamase Activity for Fluorescent Imaging and Rapid Screening of Antibiotics Resistant Bacteria. Q. Shao, Y. Zheng, X. Dong, K. Tang, X. Yan*, B. G. Xing*. Chem. Eur. J. 2013, 19, 10903. [PDF]. 


39. NIR Light Photo-response Crosslinked Unconversion Nanocariers toward Selective Intracellular Drug Release. Y. Yang, B. Velmurugan, X. Liu*, B. G. Xing*. Small, 2013, 9, 2937.[PDF].  

38. NIR Light Controlled Photorelease of siRNA and its Targeted Intracellular Delivery Based on 

   Upconversion Nanoparticles. Y. Yang,F. Liu, X. Liu*, B. G. Xing*.Nanoscale. 2013,5, 231. [PDF]


37.Lipopolysaccharide Neutralizing Peptide-Porphyrin Conjugates for Effective Photo-inactivation and

    Intracellular Imaging of Gram-Negative Bacteria. F. Liu, Y. Lim, A. Soh, M. Harini, B. Surajit* and

    B. G. Xing.* Bioconjugate Chem. 2012, 15, 1639.[PDF].  

36. In vitro and in vivo Uncaging and Bioluminescent Imaging through Photocaged Upconversion Nanoparticles. Y. M. Yang, Q. Shao, R. Deng, C. Wang, T. Xue, K. Chen, Z. Cheng, L. Huang, X. Liu* and B. G. Xing*. Angew. Chem. Intl. Ed., 2012, 51, 3125-3127.  [Selected as "Hot Paper" and Featured as "inside cover" in Angew. Chem.].[PDF].[US patent application, 2011]. 


35. Enzyme Responsive Luminescent Ruthenium (II) Caphalosporin Probe for Intracellular Imaging and Photoinactivation of Antibiotics Resistant Bacteria. Q. Shao and B. G. Xing*. Chem. Comm. 2012, 48, 1739-1741. [Featured as "backcover"] and [highlighted by American Chemical Society (ACS) as a "Noteworthy Chemistry" item.].[PDF]


34.Molecular Interactions Between Glycopeptide Vancomcyin and Bacterial Cell Wall Peptideanalogs. B. G. Xing*, T.T. Jiang, X. Wu, R. Liew, J. Zhou, D.W. Zhang*, E. Yeow* etc. Chem. Eur. J. 2011, 17, 14170-14177. [PDF].


33. Enzyme Responsive Multifunctional Magnetic Nanoparticles for Tumor Intracellular Drug Delviery and Imaging. Y. M. Yang, J, X, Aw, K. Chen, Z. Cheng*, B. G. Xing*.Chem. Asian. J. 2011, 6, 1381-1389. [Featured as "front cover"] and highlighted as "Hot topics in Click Chemistry in Wiley-VCH"; "Hot Topics in Drug Delivery in Wiley-VCH"; and "Hottest articles in Medicinal and Pharmaceutical Chemistry in Wiley- VCH". [PDF]. 


32. Multifunctional Divalent Vancomcyin: The Fluorescent  Imaging  and  Photodynamic  Antimicrobial Properties for Drug Resistant Bacteria. B. G. Xing*, T. T. Jiang, W. Bi, Y. Y. Yang, L. H. Li, M. L. Ma, C. Chiang, B. Xu*, E. Yeow* etc. Chem. Comm. 2011, 47, 1601-1603. [PDF].[US patent application, 2010]. 


31. Mechanical Nanosprings: Induced Coiling and Uncoling of Ultrathin Nanowires. J. Xu, H. Wang, C. Liu, Y. M. Yang, X. G. Liu, B. G. Xing*, H. Y. Chen.* J. Am. Chem. Soc. 2010, 132, 11920-11922. [PDF].

30. Chemsitry of Optical Imaging Probes. Q.Shao, Y. M. Yang, B. G. Xing*, Book: Molecular Imaging Probes for Cancer Research. Chapter 14, World Science. 2010. 

29. Synthesis and characterization of 2-(2'-hydroxy-5'-chlorophenyl)-6-chloro-4(3H)-Quninazoline based fluorogenic probes for cellular imaging of monoamine oxidases. J. X. Aw, Q. Shao, Y. M. Yang, B. G. Xing* etc. Chem. Asian. J. 2010, 5, 1317-1321.[PDF]. [US patent application, Granted 2009].


28. Photoactive molecules for applications in molecular imaging and cell biology. Q. Shao, B. G. Xing*. Chem. Soc. Rev. 2010, 39, 2835-2846.[PDF].                                                


27. Radiation Luminescence excited quantum dots for in vivo multiplexed optical imaging. H. G. Liu, X. F. Zhang, B. G. Xing, P. Han, S. S. Gambhir, Z. Cheng* Small. 2010, 6, 1087-1091. Featured as "Inside cover").


26. Metallic Nanoparticles Bioassay for Enterobacter cloacae P99 B-lactamase activity and inhibition screening. R. R. Liu, W. L. Teo, S. Y. Tan, B. G. Xing* etc. Analyst. 2010, 135, 1031-1036. Featured as "Back cover". [PDF]. 


25. Novel trimethyl lock based enzyme switch for the self-assembly and disassembly of Gold nanoparticles. R. R. Liu, J. X. Aw, W. L. Teo, B. G. Xing* etc. New J. Chem. 2010, 34, 594-598. (Invited). [PDF]


24. Photoactivable Bioluminescent Probes for Imaging Luciferase Activity. Q. Shao, T. T. Jiang, G. Ren, Z. Chen*, B. G. Xing*. Chem. Comm. 2009, 15, 4028. [Selected as "Hot Article" in Chem. Comm.: and was highlighted by ChemInform (2009, 40 issue 46), Analytica-World and Bionity].[PDF].[US patent application, 2009].  

23. Simple and Rapid Synthesis of Ultrathin Gold Nanowires, Their Self-Assembly and Application in Surface-Enhanced Raman Scattering. H. Feng; Y. Yang; Y. You; L. Li; J. Guo; T. Yu; Z. Shen; T. Wu; B. G. Xing*. Chem. Comm. 2009, 15, 1984-1986. [PDF].

22. A Gold-Nanoparticel Based Colorimetric Screening Method for Baterial Enzymatic Inhibition. T. T. Jiang; B. G. Xing*. Chem. Comm. 2009, 15, 1972-1974. [PDF]

21. Recent Developments of Biological Reporter Technology in Gene Expression. T. T. Jiang; B. G. Xing*; J. H. Rao; etc. Biotechnology and Genetic Engineering Reviews. 2008, 25, 41-76. [PDF]

20. Method and substrates for Bacterial Enzyme Identification. B. G. Xing*; X. Hung; T. T. Jiang; R. R. Liu; etc. (p.139, US patent application, 2008).

19. Novel Beta-Lactam Antibiotics Derivatives: Their New Applications as Gene Reporters, Antitumor, Prodrugs and Enzyme Inhibitors. R. R. Liu; B. G. Xing*; J. H. Rao. Mini-Reviews in Medicinal Chemistry, 2008, 8, 455-471. [PDF]. Top 10 articles published inthe same domain since the publication in 2010 (from BioMedLib).

18. A Simple and Specific Assay for Real Time Colorimetric Visualization of Beta-Lactamase activity by Using Gold Nanoparticles. R. R. Liu; R. S. Liew; J. Zhou; B. G. Xing* etc. Angew. Chem. Int. Ed., 2007, 46, 8799-8803. [PDF],[US patent application, Granted, 2008].



Before Joining NTU:

17. A self-assembled quantum dot probe for detecting beta-lactamase activity. C. J. Xu; B. G. Xing; J. H. Rao. Biochem. & Biophys. Research Comm. 2006, 344, 931-935. [PDF]

16. Imaging Gene Expression with a Cell-permeable Near Infrared ß-Lactamase Substrates. B.G Xing, J.H. Rao. J. Am. Chem. Soc. 2005, 127, 4158-4159. [PDF]

15. Novel Fluorogenic Substrates for Imaging b-Lactamase Gene Expression. W.Z. Gao, B. G. Xing, R.Y. Tsien and J.H. Rao. J. Am. Chem. Soc. 2003, 125, 11146-11147. [PDF]

14. Multivalency via a Metal Complex: Potent Divalent Vancomycins against Vancomycin Resistance Enterococci (VRE). B. G. Xing, C. W. Yu and B. Xu. J. Med. Chem. 2003, 46, 4904-4909. [PDF]

13. Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci(VRE). B. G. Xing, P. L. Ho, C-W. Yu, H. W. Gu and B. Xu. Chem. Comm. 2003, 17, 2224-2225. [PDF]

12. Hydrophobic Interaction and Hydrogen Bonding Cooperatively Confer A Vancomycin Hydrogel: A Potential Candidate for Biomaterials. B. G. Xing, C. W. Yu, D. G. Fu and B. Xu. J. Am. Chem. Soc. 2002, 124, 14846-14847. [PDF]

11. Spontaneous Enrichment of Organic Molecules from Aqueous and Gas Phases Into A Stable Metallogel. B. G. Xing, M. F. Choi and B. Xu. Langmuir. 2002, 18, 9654-9658. [PDF]

10. Rational Design of Coordination Polymer Gels as A Novel Catalytic System. B. G. Xing, M. F. Choi and B. Xu. Chem. Eur. J. 2002, 8, 5028-5032. [PDF]

9. A Stable Metal Coordination Polymer Gel Based on a Calix[4]arene and its Uptake of Non-ionic Organic Molecules from the Aqueous Phase. B. G. Xing, M. F. Choi and B. Xu. Chem. Comm. 2002, 4, 362-363.

8. The in Vitro Binding of an Orally Active Platinum Anti-tumor Drug, JM216 to Metallothionein. B. G. Xing, H. Zhu, and W. X. Tang. BioMetals. 2001, 14, 51-57.

7. Kinetic Studies of the Reactions of Some Metal Reconstituted Metallothioneins with Electrophilic Disulfide 5, 5’-dithiobis(2-nitrobenzoic acid) (DTNB). B. G. Xing, Y. B. Shi and W. X. Tang. BioMetals. 2000, 13, 295-300.

6. Binding Properties of an Orally Active Platinum Anti-tumor Drug JM216 with Metallothionein in Vivo. B. G. Xing, H. F. Zhu, Y. Wang and W. X. Tang. BioMetals. 2000, 13, 203-208.

5. Structure Studies of Platinothioneins by Using Extended X-ray Absorption Structure Spectroscopy (EXAFS). B. G. Xing, L. Chen, P. Huang and W. X. Tang. Spectroscopy letters. 1999, 32, 883-894.

4. Study on the Interaction of Human Serum Albumin with Cu(II) and Fe(III) by Fluorescence Method. H. Liang, B. G. Xing, Q. X. Wu and P. W. Shen. Acta Chim. Sinica. 1999, 57, 161-165.

3. Secondary Structure of Rabbit Cd5Zn2MT, Zn7MT and Pt7MT by Fourier Transform Infrared Spectroscopy. P. Huang, B. G. Xing and W. X. Tang. Spectroscopy letters. 1998, 31, 1599-1608.

2. Binding Properties and Stoichiometries of a Palladium (II) Complex to Metallothioneins in Vivo and in Vitro. Q. Zhang, W. Q. Zhong, B. G. Xing, W. X. Tang. J. Inorg. Biochem. 1998, 72, 3-4.

1. Equilibrium Dialysis Study on the Interaction between Cu(II) and HSA or BSA. H. Liang, B. G. Xing, X. Wang, Y. Yuan and P. W. Shen. Chinese Science Bulletin. (English Edition) 1998, 43, 404-408.