CURRICULUM VITAE

Assistant Professor Xing Bengang
School of Physical & Mathematical Sciences
Nanyang Technological University
SPMS-04-01, 21 Nanyang link
Singapore 637371

E-mail: bengang@ntu.edu.sg
Tel: (+65) 6316 8758
Fax: (+65) 6316 6984

Educational and Professional Qualifications


 

1994

B. Sc. (Chemistry) Xingjiang Teachers University, PR China.

2000

Ph. D. (Bioinorganic Chemistry) Nanjing university, PR China (under supervision of Prof. TANG Wenxia)

 

Professional Experience               
 

Dec 00 – Jan 03

Research Associate, Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong

Jan 03 – Feb 04

Postdoctoral research fellow, Crump Institute for Molecular Imaging, University of California, Los Angeles, USA

Feb 04 - Dec 05 

Postdoctoral researcher, Molecular Imaging Programs at Stanford University (MIPS), USA

 

Post-doc positions available:

 

Our labs are opening for post-doc position application in the research fields of nanobiotechnology, fluorescent imaging, organic synthesis and biomaterials.

 

Candidates should have ph. D degree with the strong background in the nanobiotechnology, fluorescent imaging, organic synthesis, single molecular fluorescence detection or relevant research training. Biological chemistry background is not preferred, but will be plus. The highly motivated and independent Ph. D students who are interested in the interdisciplinary research projects are welcome to apply.

 

Ph. D student position available:

 

Now my lab is opening for application of Ph. D program. All the students who are highly self-motivated and want to try out interesting research in the frontier field of nanobiotechnology, fluorescent imaging, biomaterials and medicinal chemistry are welcome to apply.

Research Interest

Our research interests will be highly interdisciplinary in the interface of nanobiotechnology, fluorescent imaging, organic synthesis, biomaterials as well as medicinal chemistry. Specific aims of ours are to integrate the basic knowledge and techniques to design, develop and identify the small molecules, natural products, peptides and/or their analogues for probing some special biological molecular. We are also interested in development of new functional nanomaterials for enzyme detection, drug delivery and clinical diagnosis.

1.      Nanobiotechnology: Developments of nanoparticles, carbon nanotube, quantum dots etc. based nanomaterials for drug delivery, biocatalysis, biomolecular imaging or relevant biomedical applications.

2.   Fluorescent imaging: Design and synthesis of new fluorescent probes for real time detection of biological active molecules (β-galactosidase, proteases, oxidases and β-lactamase etc.).

3.      Biomaterials: Design, synthesis and characterization of new transporters and/or the peptides based hydrogels for biomedical application.

 

Awards:

1999

National Scholarship for Outstanding Graduate Students, Nanjing University

2005

Young Investigator Travel Scholarship, Molecular Imaging Programs at Stanford University

2007

Lectureship Award, 2nd International Conference on Cutting-Edge Organic Chemistry in Asia, Pusan, South Korea

Refereed Publications

After joining NTU

      21. Method and substrates for Bacterial Enzyme Identification. B. G. XING*; X. HUNG; T. T. JIANG; R. R. LIU; etc. (p.139, US patent appliction, 2008). 

      20. A Gold-Nanoparticel Based Colorimetric Screening Method for Baterial Enzymatic Inhibition. X. HUNG; T. T. JIANG; R. R. LIU; B. G. XING* (Submitted, 2008). 

19. Novel Beta-Lactam Antibiotics Derivatives: Their New Applications As Gene Reporters, Antitumor Prodrugs and Enzyme Inhibitors. R. R. LIU; B. G. XING*; J. H. RAO. Mini-Reviews in Medicinal Chemistry, 8, 455-471, 2008 [link].  

18.   A Simple and Specific Assay for Real Time Colorimetric Visualization of Beta-Lactamase activity by Using Gold Nanoparticles. R. R. LIU; R. S. LIEW; J. ZHOU; B. G.XING*. Angew. Chem. Int. Ed. 46, 8799-8803, 2007 [link].

 

Before joining NTU

17.   A self-assembled quantum dot probe for detecting beta-lactamase activity. C.J. XU; B. G. XING; J. H. RAO. Biochem. & Biophys. Research Comm. 344(3), 931-935, 2006 [link].

16.   Imaging Gene Expression with a Cell-permeable Near Infrared β-Lactamase Substrates. B.G Xing, J.H. Rao, J. Am, Chem, Soc, 127 (12), 4158-4159, 2005 [link]. 

15.   Novel Fluorogenic Substrates for Imaging b-Lactamase Gene Expression. W.Z. Gao, B.G. Xing, R.Y. Tsien and J.H. Rao, J. Am, Chem, Soc, 125(37),11146-11147, 2003 [link].

14.   Hydrophobic Interaction and Hydrogen Bonding Cooperatively Confer A Vancomycin Hydrogel: A Potential Candidate for Biomaterials B. G. Xing, C. W. Yu, D. G. Fu and B. Xu, J. Am, Chem, Soc, 124 (50), 14846-14847, 2002 [link].

13.   Multivalency via a Metal Complex: Potent Divalent Vancomycins against Vancomycin Resistance Enterococci (VRE) B. G. Xing, C. W. Yu and B. Xu, J. Med. Chem; 46(23), 4904-4909, 2003 [link].

12.   Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci(VRE) B. G. Xing, P. L. Ho, C-W. Yu, H. W. Gu and B. Xu; Chem. Comm. 17, 2224-2225, 2003 [link].

11.   Spontaneous Enrichment of Organic Molecules from Aqueous and Gas Phases Into A Stable Metallogel B. G. Xing, M. F. Choi and B. Xu; Langmuir, 18, 9654-9658, 2002 [link].

10.   Rational Design of Coordination Polymer Gels as A Novel Catalytic System B. G. Xing, M. F. Choi and B. Xu, Chem. Eur. J. 8(21), 5028-5032, 2002 [link].

9.       A Stable Metal Coordination Polymer Gel Based on a Calix[4]arene and its Uptake of Non-ionic Organic Molecules from the Aqueous Phase B. G. Xing, M. F. Choi and B. Xu; Chem. Comm. 4, 362-363, 2002.

8.       The in Vitro Binding of an Orally Active Platinum Anti-tumor Drug, JM216 to Metallothionein B. G. Xing, H. Zhu, and W. X. Tang; BioMetals, 14(1), 51-57, 2001.

7.       Kinetic Studies of the Reactions of Some Metal Reconstituted Metallothioneins with Electrophilic Disulfide 5, 5’-dithiobis(2-nitrobenzoic acid) (DTNB) B. G. Xing, Y. B. Shi and W. X. Tang, BioMetals, 13 (4), 295-300, 2000.

6.       Binding Properties of an Orally Active Platinum Anti-tumor Drug JM216 with Metallothionein in Vivo B. G. Xing, H. F. Zhu, Y. Wang and W. X. Tang; BioMetals, 13(3), 203-208, 2000.

5.       Structure Studies of Platinothioneins by Using Extended X-ray Absorption Structure Spectroscopy (EXAFS) B. G. Xing, L. Chen, P. Huang and W. X. Tang, Spectroscopy letters, 32(5), 883-894, 1999.

4.       Study on the Interaction of Human Serum Albumin with Cu(II) and Fe(III) by Fluorescence Method H. Liang, B. G. Xing, Q. X. Wu and P. W. Shen; Acta Chim. Sinica, 57(2), 161-165, 1999.

3.       Secondary Structure of Rabbit Cd5Zn2MT, Zn7MT and Pt7MT by Fourier Transform Infrared Spectroscopy P. Huang, B. G. Xing and W. X. Tang, Spectroscopy letters, 31(7), 1599-1608, 1998.

2.       Binding Properties and Stoichiometries of a Palladium (II) Complex to Metallothioneins in Vivo and in Vitro. Q. Zhang, W. Q. Zhong, B. G. Xing, W. X. Tang; J. Inorg. Biochem., (72), 3-4, 1998.

1.       Equilibrium Dialysis Study on the Interaction between Cu(II) and HSA or BSA H. Liang, B. G. Xing, X. Wang, Y. Yuan and P. W. Shen; Chinese Science Bulletin,

      (English edition) 43(5) (1998) 404-408.